CENPL

CENPL
Identifikatori
Aliasi	CENPL
Vanjski ID-jevi	OMIM: 611503 MGI: 1917704 HomoloGene: 19618 GeneCards: CENPL
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	173,824,720 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	160,914,294 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• hromosom; • citosol; • Primarno suženje; • jedro; • nukleoplazma;
Biološki proces	• GO:0061641 CENP-A containing chromatin assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	91687
	70454
	ENSG00000120334
	ENSMUSG00000026708
	Q8N0S6
	Q3U3S3
	NM_033319; NM_001127181; NM_001171182
	NM_001159930; NM_027429
	NP_001120653; NP_001164653; NP_201576
	NP_001153402
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Centromerni protein L jest protein koji je kod ljudi kodiran genom CENPL sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 344 aminokiseline, a molekulska težina 38.998 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDSYSAPEST	PSASSRPEDY	FIGATPLQKR	LESVRKQSSF	ILTPPRRKIP
QCSQLQEDVD	PQKVAFLLHK	QWTLYSLTPL	YKFSYSNLKE	YSRLLNAFIV
AEKQKGLAVE	VGEDFNIKVI	FSTLLGMKGT	QRDPEAFLVQ	IVSKSQLPSE
NREGKVLWTG	WFCCVFGDSL	LETVSEDFTC	LPLFLANGAE	SNTAIIGTWF
QKTFDCYFSP	LAINAFNLSW	MAAMWTACKM	DHYVATTEFL	WSVPCSPQSL
DISFAIHPED	AKALWDSVHK	TPGEVTQEEV	DLFMDCLYSH	FHRHFKIHLS
ATRLVRVSTS	VASAHTDGKI	KILCHKYLIG	VLAYLTELAI	FQIE

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120334 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026708 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (maj 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (maj 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
^ "Entrez Gene: CENPL centromere protein L".
^ "UniProt, Q8N0S6" (jezik: en.). Pristupljeno 2021-12-8. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CENPL i stranica sa detaljima o genu CENPL u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120334 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026708 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16622420-5] Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (maj 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.

[pmid16622419-6] Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (maj 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.

[entrez-7] "Entrez Gene: CENPL centromere protein L".

[UniProt-8] "UniProt, Q8N0S6" (jezik: en.). Pristupljeno 2021-12-8. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)CS1 održavanje: nepoznati jezik (link)

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