COMMD9
Protein 9 sa domenom COMM je protein koji je kod ljudi kodiran genom COMMD9.[5][6]
MURR1 je multifunkcionalni protein koji inhibira jedarni faktor kapaB (NF-kapaB), transkripcijski faktor s plejotropnim funkcijama koji utiču na urođeni i adaptivni imunitet, apoptozu, regulaciju ćelijskog ciklusa i onkogenezu. U jednoj od studija koje fokusiraju ove procese, saopćeno je o otkriću nove porodice proteina s homologijom na MURR1. Nađeno je da vi proteini tvore multimerne komplekse i identificirani su u biohemijskom pregledu na faktore povezane s MURR1. Porodica je definirana prisutnošću konzerviranog i jedinstvenog motiva zvanog COMM (gen domena za metabolizam bakra MURR1), koji funkcionira kao interfejs za interakcije protein-protein. Kao i MURR1, neki od ovih faktora također se povezuju i inhibiraju NF-kapaB. Proteini označeni kao COMMD ili COMM domeni 1-10 opsežno su konzervirani u višećelijskim eukariotskim organizmima i definiraju novu porodicu strukturnih i funkcionalnih homologa MURR1. Prototip ove porodice, MURR1/COMMD1, potiskuje NF-kapaB, ne utiući na jedarnu translokaciju ili vezivanje NF-kapaB za srodne motive, već funkcionira u jedru utičući na povezanost NF-kapaB s hromatinom.[7]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 198 aminokiselina, a molekulska težina 21.819 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAALTAEHFA | ALQSLLKASS | KDVVRQLCQE | SFSSSALGLK | KLLDVTCSSL | ||||
| SVTQEEAEEL | LQALHRLTRL | VAFRDLSSAE | AILALFPENF | HQNLKNLLTK | ||||
| IILEHVSTWR | TEAQANQISL | PRLVDLDWRV | DIKTSSDSIS | RMAVPTCLLQ | ||||
| MKIQEDPSLC | GDKPSISAVT | VELSKETLDT | MLDGLGRIRD | QLSAVASK |
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000110442 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027163 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, Maine GN, Wilkinson JC, Mayo MW, Duckett CS (Jun 2005). "COMMD proteins, a novel family of structural and functional homologs of MURR1". J Biol Chem. 280 (23): 22222–32. doi:10.1074/jbc.M501928200. PMID 15799966.
- ^ "Entrez Gene: COMMD9 COMM domain containing 9".
- ^ Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- ^ "UniProt, Q9P000". Pristupljeno 20. 8. 2021.
Dopunska literatura
[uredi | uredi izvor]- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Vanjski linkovi
[uredi | uredi izvor]- Lokacija ljudskog genoma COMMD9 i stranica sa detaljima o genu COMMD9 u UCSC Genome Browseru.