CSDC2

CSDC2
Identifikatori
Aliasi	CSDC2
Vanjski ID-jevi	OMIM: 617689 MGI: 2146027 HomoloGene: 8701 GeneCards: CSDC2
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	41,577,741 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	81,835,142 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK; • nucleic acid binding; • mRNA 3'-UTR binding; • transcription factor binding;
Ćelijska komponenta	• jedro; • citoplazma;
Biološki proces	• mRNA processing; • GO:0009373 regulation of transcription, DNA-templated; • regulation of mRNA stability;
	Izvori:Amigo / QuickGO
Ortolozi
	27254
	105859
	ENSG00000172346
	ENSMUSG00000042109
	Q9Y534
	Q91YQ3
	NM_014460
	NM_145473
	NP_055275
	NP_663448
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein C2 sa domenom hladnog šoka jest protein koji je kod ljudi kodiran genom CSDC2 sa hromosoma 22.^[5]^[6] Razvijen je sistemski pristup generiranju klonova cDNK koji sadrže otvorene okvire čitanja pune dužine (ORF-ovi), koristeći znanje o strukturi gena iz genomske sekvence. Svaki ORF je amplificiran PCR-om iz skupa primarnih cDNK, kloniran i potvrđen sekvenciranjem. Dobijeni su klonovi koji predstavljaju 70% gena na ljudskom hromosomu 22, dok je pretraživanjem dostupnih kolekcija klonova cDNK pronađeno u najboljem slučaju 48% iz jedne kolekcije i 60% za sve kolekcije zajedno.^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 153 aminokiseline, a molekulska težina 16.786 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MTSESTSPPV	VPPLHSPKSP	VWPTFPFHRE	GSRVWERGGV	PPRDLPSPLP
TKRTRTYSAT	ARASAGPVFK	GVCKQFSRSQ	GHGFITPENG	SEDIFVHVSD
IEGEYVPVEG	DEVTYKMCPI	PPKNQKFQAV	EVVLTQLAPH	TPHETWSGQV
VGS

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172346 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042109 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Castiglia D, Scaturro M, Nastasi T, Cestelli A, Di Liegro I (Mar 1996). "PIPPin, a putative RNA-binding protein specifically expressed in the rat brain". Biochem Biophys Res Commun. 218 (1): 390–4. doi:10.1006/bbrc.1996.0068. PMID 8573167.
^ Raimondi L, D'Asaro M, Proia P, Nastasi T, Di Liegro I (maj 2003). "RNA-binding ability of PIPPin requires the entire protein". J Cell Mol Med. 7 (1): 35–42. doi:10.1111/j.1582-4934.2003.tb00200.x. PMC 6740078. PMID 12767259.
^ "Entrez Gene: CSDC2 cold shock domain containing C2, RNA binding".
^ "UniProt, Q9Y534" (jezik: engleski). Pristupljeno 05-02-2022. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)

Dopunska literatura[uredi | uredi izvor]

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nastasi T, Scaturro M, Bellafiore M, et al. (1999). "PIPPin is a brain-specific protein that contains a cold-shock domain and binds specifically to H1 degrees and H3.3 mRNAs". J. Biol. Chem. 274 (34): 24087–93. doi:10.1074/jbc.274.34.24087. PMID 10446180.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Nastasi T, Muzi P, Beccari S, et al. (2001). "Specific neurons of brain cortex and cerebellum are PIPPin positive". NeuroReport. 11 (10): 2233–6. doi:10.1097/00001756-200007140-00034. PMID 10923677. S2CID 28313328.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Schäfer C, Steffen H, Krzykowski KJ, et al. (2003). "CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (4): G726–34. doi:10.1152/ajpgi.00111.2003. PMID 12801884.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CSDC2 i stranica sa detaljima o genu CSDC2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172346 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042109 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8573167-5] Castiglia D, Scaturro M, Nastasi T, Cestelli A, Di Liegro I (Mar 1996). "PIPPin, a putative RNA-binding protein specifically expressed in the rat brain". Biochem Biophys Res Commun. 218 (1): 390–4. doi:10.1006/bbrc.1996.0068. PMID 8573167.

[pmid12767259-6] Raimondi L, D'Asaro M, Proia P, Nastasi T, Di Liegro I (maj 2003). "RNA-binding ability of PIPPin requires the entire protein". J Cell Mol Med. 7 (1): 35–42. doi:10.1111/j.1582-4934.2003.tb00200.x. PMC 6740078. PMID 12767259.

[entrez-7] "Entrez Gene: CSDC2 cold shock domain containing C2, RNA binding".

[UniProt-8] "UniProt, Q9Y534" (jezik: engleski). Pristupljeno 05-02-2022. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)

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