EMCN
| EMCN | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||||||||||||||||
| Aliasi | EMCN | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 608350 MGI: 1891716 HomoloGene: 9438 GeneCards: EMCN | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 4: 100.4 – 100.88 Mb | Chr 3: 137.05 – 137.14 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Endomucin jest protein koji je kod ljudi kodiran genom EMCN sa hromosoma 4.[5][6][7] Endomucin je marker za endolelne[8] i hematopoetske matične ćelije.[9]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 261 aminokiselina, а molekulska težina 27.452 Da.[10]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MELLQVTILF | LLPSICSSNS | TGVLEAANNS | LVVTTTKPSI | TTPNTESLQK | ||||
| NVVTPTTGTT | PKGTITNELL | KMSLMSTATF | LTSKDEGLKA | TTTDVRKNDS | ||||
| IISNVTVTSV | TLPNAVSTLQ | SSKPKTETQS | SIKTTEIPGS | VLQPDASPSK | ||||
| TGTLTSIPVT | IPENTSQSQV | IGTEGGKNAS | TSATSRSYSS | IILPVVIALI | ||||
| VITLSVFVLV | GLYRMCWKAD | PGTPENGNDQ | PQSDKESVKL | LTVKTISHES | ||||
| GEHSAQGKTK | N |
Funkcija
[uredi | uredi izvor]EMCN je mucinoliki sijaloglikoprotein koji ometa sastavljanje fokusnih adhezijskih kompleksa i inhibira interakciju između ćelija i vanćelijskog matriksa.[5][7]
References
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000164035 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054690 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (juni 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125. S2CID 23615506.
- ↑ Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (oktobar 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
- 1 2 "Entrez Gene: EMCN endomucin".
- ↑ Liu C, et al. (2001). "Human Endomucin Is an Endothelial Marker". Biochemical and Biophysical Research Communications. 288: 129–136. doi:10.1006/bbrc.2001.5737. PMID 11594763.
- ↑ Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483–1492. doi:10.1084/jem.20051325. PMC 2213340. PMID 16314436.
- ↑ "UniProt, Q9ULC0" (jezik: engleski). Pristupljeno 25. 10. 2021.
Dopunska literatura
[uredi | uredi izvor]- Li G, Miles A, Line A, Rees RC (mart 2004). "Identification of tumour antigens by serological analysis of cDNA expression cloning". Cancer Immunology, Immunotherapy. 53 (3): 139–43. doi:10.1007/s00262-003-0471-y. PMID 14722670. S2CID 10785466.
- Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, Böcker W, Vestweber D (maj 2002). "Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope". The American Journal of Pathology. 160 (5): 1669–81. doi:10.1016/S0002-9440(10)61114-5. PMC 1850881. PMID 12000719.
- Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC (juni 2002). "Serological identification and expression analysis of gastric cancer-associated genes". British Journal of Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
- Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D, Vestweber D (decembar 2002). "Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin". The Journal of Investigative Dermatology. 119 (6): 1388–93. doi:10.1046/j.1523-1747.2002.19647.x. PMID 12485444.
- Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M, Noda M, Kannagi R, Hirata T, Murai T, Fukuda M, Miyasaka M (septembar 2004). "Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling". International Immunology. 16 (9): 1265–74. doi:10.1093/intimm/dxh128. PMID 15249540.
- Reckzeh K.; Kizilkaya H.; Søgaard Helbo A.; Estruch Alrich M.; et al. (2018). "Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin". Blood Advances. 2 (13): 1628–1632. doi:10.1182/bloodadvances.2018015743. PMC 6039657. PMID 29986855.</ref>