EXTL2
Egzostozinoliki protein 2 jest protein koji je kod ljudi kodiran genom EXTL2 sa hromosoma 1.[5][6][7]
Amiokiselininska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 330 aminokiselina, a molekulska težina 37.466 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MRCCHICKLP | GRVMGIRVLR | LSLVVILVLL | LVAGALTALL | PSVKEDKMLM | ||||
| LRREIKSQGK | STMDSFTLIM | QTYNRTDLLL | KLLNHYQAVP | NLHKVIVVWN | ||||
| NIGEKAPDEL | WNSLGPHPIP | VIFKQQTANR | MRNRLQVFPE | LETNAVLMVD | ||||
| DDTLISTPDL | VFAFSVWQQF | PDQIVGFVPR | KHVSTSSGIY | SYGSFEMQAP | ||||
| GSGNGDQYSM | VLIGASFFNS | KYLELFQRQP | AAVHALIDDT | QNCDDIAMNF | ||||
| IIAKHIGKTS | GIFVKPVNMD | NLEKETNSGY | SGMWHRAEHA | LQRSYCINKL | ||||
| VNIYDSMPLR | YSNIMISQFG | FPYANYKRKI |
Funkcija[uredi | uredi izvor]
EXTL2 glikoziltransferaza potrebna je za biosintezu heparan-sulfata i odgovorna je za naizmjenično dodavanje beta-1-4-vezane glukuronske kiseline (GlcA) i alfa-1-4-vezanih N-acetilglukozamin (GlcNAc) jedinica u nastajajuće heparan-sulfatne lance. (https://www.phosphosite.org/overviewExecuteAction?id=5020882)
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000162694 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027963 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.
- ^ Sobhany M, Dong J, Negishi M (Jun 2005). "Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase". J Biol Chem. 280 (25): 23441–5. doi:10.1074/jbc.M413379200. PMID 15831490.
- ^ "Entrez Gene: EXTL2 exostoses (multiple)-like 2".
- ^ "UniProt, Q9UBQ6" (jezik: engleski). Pristupljeno 25. 11. 2021.
Dopunska literatura[uredi | uredi izvor]
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- McCormick C, Duncan G, Goutsos KT, Tufaro F (2000). "The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 668–73. Bibcode:2000PNAS...97..668M. doi:10.1073/pnas.97.2.668. PMC 15388. PMID 10639137.
- Kitagawa H, Shimakawa H, Sugahara K (1999). "The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate". J. Biol. Chem. 274 (20): 13933–7. doi:10.1074/jbc.274.20.13933. PMID 10318803.
- Saito T, Seki N, Yamauchi M, et al. (1998). "Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family". Biochem. Biophys. Res. Commun. 243 (1): 61–6. doi:10.1006/bbrc.1997.8062. PMID 9473480.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Vanjski linkovi[uredi | uredi izvor]
- PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Exostosin-like 2