S Wikipedije, slobodne enciklopedije
Histon H2A tip 2-Bprotein koji je kod ljudi kodiran genom HIST2H2AB sa hromosoma 1 .[ 5] [ 6]
Dužina polipeptidnog lanca je 130 aminokiselina , a molekulska težina 13.995 Da .[ 7]
10 20 30 40 50 MSGRGKQGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAVRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK TESHKPGKNK
Histoni su osnovni jedarni proteini koji su odgovorni za nukleosomsku strukturu hromosomskog vlakna u eukariotima . Nukleosomi se sastoje od približno 146 bp DNK omotane oko histonskog oktamera , sastavljenog od parova svakog od četiri jezgra histona (H2A, H2B, H3 i H4). Hromatinsko vlakno se dalje sabija kroz interakciju histonskog linkera H1 , sa DNK između nukleosoma, kako bi se formirale strukture hromatina višeg reda. Ovaj gen je bez introna i kodira člana porodice histoni H2A . Transkripti ovog gena sadrže palindromski terminacijski element.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000184270 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063689 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics . 80 (5): 487–98. doi :10.1016/S0888-7543(02)96850-3 . PMID 12408966 . ^ a b "Entrez Gene: HIST2H2AB histone cluster 2, H2ab" .^ "UniProt, Q8IUE6" (jezik: en.). Pristupljeno 12. 12. 2021 .CS1 održavanje: nepoznati jezik (link )
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