IMP3

IMP3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2CQJ
Identifikatori
Aliasi	IMP3
Vanjski ID-jevi	OMIM: 612980 MGI: 1916119 HomoloGene: 6120 GeneCards: IMP3
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	75,648,706 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	56,845,682 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• structural constituent of ribosome; • rRNA binding; • GO:0001948, GO:0016582 vezivanje za proteine; • snoRNA binding; • vezivanje sa RNK;
Ćelijska komponenta	• small ribosomal subunit; • small-subunit processome; • Mpp10 complex; • Jedarce; • intracellular anatomical structure; • jedro; • nukleoplazma; • preribosome;
Biološki proces	• positive regulation of translational fidelity; • ribosome biogenesis; • rRNA processing;
	Izvori:Amigo / QuickGO
Ortolozi
	55272
	102462
	ENSG00000177971
	ENSMUSG00000032288
	Q9NV31
	Q921Y2
	NM_018285
	NM_133976
	NP_060755
	NP_598737
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mali U3 jedarcetov ribonukleoproteinski protein IMP3 je protein koji je kod ljudi kodiran genom IMP3.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 184 aminokiseline, a molekulska težina 21.850 Da.^[8]

10	20	30	40	50
MVRKLKFHEQ	KLLKQVDFLN	WEVTDHNLHE	LRVLRRYRLQ	RREDYTRYNQ
LSRAVRELAR	RLRDLPERDQ	FRVRASAALL	DKLYALGLVP	TRGSLELCDF
VTASSFCRRR	LPTVLLKLRM	AQHLQAAVAF	VEQGHVRVGP	DVVTDPAFLV
TRSMEDFVTW	VDSSKIKRHV	LEYNEERDDF	DLEA

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Funkcija[uredi | uredi izvor]

Ovaj gen kodira ljudski homolog kvaščevog proteina Imp3. Protein se lokalizira na jedarcetu i stupa u interakciju sa kompleksom U3 snoRNP. Protein sadrži S4 domen.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177971 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032288 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (septembar 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
^ Granneman S, Gallagher JE, Vogelzangs J, Horstman W, van Venrooij WJ, Baserga SJ, Pruijn GJ (april 2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes". Nucleic Acids Research. 31 (7): 1877–87. doi:10.1093/nar/gkg300. PMC 152815. PMID 12655004.
^ ^a ^b "Entrez Gene: IMP3 IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)".
^ "UniProt, Q9NV31". Pristupljeno 15. 7. 2021.

Dopunska literatura[uredi | uredi izvor]

Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (septembar 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Cross SH, Charlton JA, Nan X, Bird AP (mart 1994). "Purification of CpG islands using a methylated DNA binding column". Nature Genetics. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (novembar 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (septembar 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (januar 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (oktobar 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (januar 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (januar 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Li C, Rock KL, Woda BA, Jiang Z, Fraire AE, Dresser K (februar 2007). "IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression". Modern Pathology. 20 (2): 242–7. doi:10.1038/modpathol.3800735. PMID 17192788.

Vanjski linkovi[uredi | uredi izvor]

http://www.imp3.org/ Arhivirano 20. 6. 2018. na Wayback Machine

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177971 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032288 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11543634-5] Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (septembar 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.

[pmid12655004-6] Granneman S, Gallagher JE, Vogelzangs J, Horstman W, van Venrooij WJ, Baserga SJ, Pruijn GJ (april 2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes". Nucleic Acids Research. 31 (7): 1877–87. doi:10.1093/nar/gkg300. PMC 152815. PMID 12655004.

[entrez-7] "Entrez Gene: IMP3 IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)".

[UniProt-8] "UniProt, Q9NV31". Pristupljeno 15. 7. 2021.

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