MOSC2

MOSC2
Identifikatori
Aliasi	MTARC2
Vanjski ID-jevi	OMIM: 614127 MGI: 1914497 HomoloGene: 9904 GeneCards: MTARC2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	220,784,815 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	184,578,648 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• molybdopterin cofactor binding; • molybdenum ion binding; • oxidoreductase activity; • pyridoxal phosphate binding; • nitrate reductase activity; • catalytic activity;
Ćelijska komponenta	• Peroksisom; • mitohondrija; • membrana; • mitochondrial outer membrane;
Biološki proces	• detoxification of nitrogen compound; • nitrate metabolic process; • xenobiotic metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	54996
	67247
	ENSG00000117791
	ENSMUSG00000073481
	Q969Z3
	Q922Q1
	NM_017898; NM_001317338; NM_001331042
	NM_133684; NM_001368285; NM_001368286
	NP_001304267; NP_001317971; NP_060368
	NP_598445; NP_001355214; NP_001355215
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mitohondrijski protein 2 sa domenom MOSC jest protein koji je kod ljudi kodiran genom MOSC2 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 335 aminokiselina, a molekulska težina 38.023 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGASSSSALA	RLGLPARPWP	RWLGVAALGL	AAVALGTVAW	RRAWPRRRRR
LQQVGTVAKL	WIYPVKSCKG	VPVSEAECTA	MGLRSGNLRD	RFWLVIKEDG
HMVTARQEPR	LVLISIIYEN	NCLIFRAPDM	DQLVLPSKQP	SSNKLHNCRI
FGLDIKGRDC	GNEAAKWFTN	FLKTEAYRLV	QFETNMKGRT	SRKLLPTLDQ
NFQVAYPDYC	PLLIMTDASL	VDLNTRMEKK	MKMENFRPNI	VVTGCDAFEE
DTWDELLIGS	VEVKKVMACP	RCILTTVDPD	TGVIDRKQPL	DTLKSYRLCD
PSERELYKLS	PLFGIYYSVE	KIGSLRVGDP	VYRMV

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117791 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073481 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Anantharaman V, Aravind L (Mar 2002). "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases". FEMS Microbiol Lett. 207 (1): 55–61. doi:10.1016/S0378-1097(01)00515-8. PMID 11886751.
^ "Entrez Gene: MOSC2 MOCO sulphurase C-terminal domain containing 2".
^ "UniProt, Q969Z3" (jezik: engleski). Pristupljeno 14. 12. 2021.

Dopunska literatura[uredi | uredi izvor]

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Havemeyer A, Bittner F, Wollers S, et al. (2007). "Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme". J. Biol. Chem. 281 (46): 34796–802. doi:10.1074/jbc.M607697200. PMID 16973608.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117791 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073481 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11886751-5] Anantharaman V, Aravind L (Mar 2002). "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases". FEMS Microbiol Lett. 207 (1): 55–61. doi:10.1016/S0378-1097(01)00515-8. PMID 11886751.

[entrez-6] "Entrez Gene: MOSC2 MOCO sulphurase C-terminal domain containing 2".

[UniProt-7] "UniProt, Q969Z3" (jezik: engleski). Pristupljeno 14. 12. 2021.

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