PSRC1

PSRC1
Identifikatori
Aliasi	PSRC1
Vanjski ID-jevi	OMIM: 613126 MGI: 1913099 HomoloGene: 49603 GeneCards: PSRC1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	109,283,186 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	108,295,547 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • microtubule binding;
Ćelijska komponenta	• spindle microtubule; • citoskelet; • Diobeno vreteno; • citosol; • microtubule cytoskeleton; • spindle pole; • midbody; • citoplazma; • nukleoplazma;
Biološki proces	• mitotic metaphase plate congression; • negative regulation of cell growth; • microtubule bundle formation; • regulation of mitotic spindle organization; • Ćelijska dioba; • ćelijski ciklus; • GO:0006928 cellular process; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of microtubule polymerization; • positive regulation of cyclin-dependent protein serine/threonine kinase activity;
	Izvori:Amigo / QuickGO
Ortolozi
	84722
	56742
	ENSG00000134222
	ENSMUSG00000068744
	Q6PGN9; Q5T2Z0
	Q9D0P7
NM_001005290; NM_001032290; NM_001032291; NM_032636; NM_001350237;
	NM_001350238; NM_001350239; NM_001350240; NM_001350241; NM_001350242; NM_001363309; NM_001394002; NM_001394003; NM_001394004; NM_001394005
	NM_001190161; NM_019976
NP_001005290; NP_001027462; NP_116025; NP_001337166; NP_001337167;
	NP_001337168; NP_001337169; NP_001337170; NP_001337171; NP_001350238
	NP_001177090; NP_064360
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Prolinom/serinom-bogati upredenozavojnički protein 1 jest protein koji je kod ljudi kodiran genom PSRC1 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 363 aminokiseline, a molekulska težina 38.796 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEDLEEDVRF	IVDETLDFGG	LSPSDSREEE	DITVLVTPEK	PLRRGLSHRS
DPNAVAPAPQ	GVRLSLGPLS	PEKLEEILDE	ANRLAAQLEQ	CALQDRESAG
EGLGPRRVKP	SPRRETFVLK	DSPVRDLLPT	VNSLTRSTPS	PSSLTPRLRS
NDRKGSVRAL	RATSGKRPSN	MKRESPTCNL	FPASKSPASS	PLTRSTPPVR
GRAGPSGRAA	ASEETRAAKL	RVSGSGEFVG	LTLKFLHPSP	PGPPTPIRSV
LAPQPSTSNS	QRLPRPQGAA	AKSSSQLPIP	SAIPRPASRM	PLTSRSVPPG
RGALPPDSLS	TRKGLPRPST	AGHRVRESGH	KVPVSQRLNL	PVMGATRSNL
QPPRKVAVPG	PTR

Funkcija[uredi | uredi izvor]

Ovaj gen kodira protein bogat prolinom. Studije srodnog mišjeg gena sugeriraju da je ovaj gen reguliran putem p53 i da može učestvovati u supresiji rasta posredovanoj preko p53. Opisane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134222 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068744 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lo PK, Wang FF (Nov 2002). "Cloning and characterization of human and mouse DDA3 genes". Biochim Biophys Acta. 1579 (2–3): 214–8. doi:10.1016/s0167-4781(02)00512-2. PMID 12427559.
^ Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF (Feb 2000). "Identification of a novel mouse p53 target gene DDA3". Oncogene. 18 (54): 7765–74. doi:10.1038/sj.onc.1203167. PMID 10618717.
^ ^a ^b "Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1".
^ "UniProt, Q6PGN9" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. doi:10.1038/ng.75. PMC 2682493. PMID 18193044.
Wallace C, Newhouse SJ, Braund P, et al. (2008). "Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia". Am. J. Hum. Genet. 82 (1): 139–49. doi:10.1016/j.ajhg.2007.11.001. PMC 2253977. PMID 18179892.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134222 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068744 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12427559-5] Lo PK, Wang FF (Nov 2002). "Cloning and characterization of human and mouse DDA3 genes". Biochim Biophys Acta. 1579 (2–3): 214–8. doi:10.1016/s0167-4781(02)00512-2. PMID 12427559.

[pmid10618717-6] Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF (Feb 2000). "Identification of a novel mouse p53 target gene DDA3". Oncogene. 18 (54): 7765–74. doi:10.1038/sj.onc.1203167. PMID 10618717.

[entrez-7] "Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1".

[UniProt-8] "UniProt, Q6PGN9" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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