RRP1B

RRP1B
Identifikatori
Aliasi	RRP1B
Vanjski ID-jevi	OMIM: 610654 MGI: 1919712 HomoloGene: 57086 GeneCards: RRP1B
Lokacija gena (čovjek) Hrom. Hromosom 21 (čovjek) Bend 21q22.3 Početak 43,659,560 bp Kraj 43,696,079 bp
Lokacija gena (miš) Hrom. Hromosom 17 (miš) Bend 17|17 B1 Početak 32,255,074 bp Kraj 32,281,839 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa RNK • GO:0001105 transcription coactivator activity • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • GO:0035328 heterochromatin • preribosome, small subunit precursor • citosol • GO:0035327 euchromatin • Jedarce • jedro • preribosome, large subunit precursor • granular component • nukleoplazma • hromosom Biološki proces • negative regulation of phosphatase activity • rRNA processing • GO:0034259 negative regulation of GTPase activity • positive regulation of apoptotic process • regulation of RNA splicing • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to virus • mRNA processing • GO:0097285 apoptoza • Prerada RNK Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23076	72462
Ensembl	ENSG00000160208	ENSMUSG00000058392
UniProt	Q14684	Q91YK2
RefSeq (mRNK)	NM_015056	NM_001163734 NM_028244
RefSeq (bjelančevina)	NP_055871	NP_001157206 NP_082520
Lokacija (UCSC)	Chr 21: 43.66 – 43.7 Mb	Chr 17: 32.26 – 32.28 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

RRP1B, skraćena verzija od homolog B proteina 1 kodiranog prerađenom ribosomskom RNK, znan i kao KIAA0179, jest ljudski gen sa hromosoma 21.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 758 aminokiselina, a molekulska težina 84.428 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAPAMQPAEI		QFAQRLASSE		KGIRDRAVKK		LRQYISVKTQ		RETGGFSQEE
LLKIWKGLFY		CMWVQDEPLL		QEELANTIAQ		LVHAVNNSAA		QHLFIQTFWQ
TMNREWKGID		RLRLDKYYML		IRLVLRQSFE		VLKRNGWEES		RIKVFLDVLM
KEVLCPESQS		PNGVRFHFID		IYLDELSKVG		GKELLADQNL		KFIDPFCKIA
AKTKDHTLVQ		TIARGVFEAI		VDQSPFVPEE		TMEEQKTKVG		DGDLSAEEIP
ENEVSLRRAV		SKKKTALGKN		HSRKDGLSDE		RGRDDCGTFE		DTGPLLQFDY
KAVADRLLEM		TSRKNTPHFN		RKRLSKLIKK		FQDLSEGSSI		SQLSFAEDIS
ADEDDQILSQ		GKHKKKGNKL		LEKTNLEKEK		GSRVFCVEEE		DSESSLQKRR
RKKKKKHHLQ		PENPGPGGAA		PSLEQNRGRE		PEASGLKALK		ARVAEPGAEA
TSSTGEESGS		EHPPAVPMHN		KRKRPRKKSP		RAHREMLESA		VLPPEDMSQS
GPSGSHPQGP		RGSPTGGAQL		LKRKRKLGVV		PVNGSGLSTP		AWPPLQQEGP
PTGPAEGANS		HTTLPQRRRL		QKKKAGPGSL		ELCGLPSQKT		ASLKKRKKMR
VMSNLVEHNG		VLESEAGQPQ		ALGSSGTCSS		LKKQKLRAES		DFVKFDTPFL
PKPLFFRRAK		SSTATHPPGP		AVQLNKTPSS		SKKVTFGLNR		NMTAEFKKTD
KSILVSPTGP		SRVAFDPEQK		PLHGVLKTPT		SSPASSPLVA		KKPLTTTPRR
RPRAMDFF

Dopunska literatura

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (oktobar 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M (juni 2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (april 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (januar 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Lehner B, Sanderson CM (juli 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (novembar 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (januar 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (februar 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.