SGIP1

SGIP1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	5AWR, 5AWT, 5AWU, 5AWS
Identifikatori
Aliasi	SGIP1
Vanjski ID-jevi	OMIM: 611540 MGI: 1920344 HomoloGene: 13001 GeneCards: SGIP1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	66,751,139 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	102,973,628 bp
Ontologija gena
Molekularna funkcija	• microtubule binding; • SH3 domain binding; • vezivanje tubulina; • GO:0001948, GO:0016582 vezivanje za proteine; • phospholipid binding; • cytoskeletal protein binding;
Ćelijska komponenta	• citoplazma; • ćelijska membrana; • clathrin-coated pit; • AP-2 adaptor complex; • membrana; • clathrin-coated vesicle; • citosol; • citoskelet;
Biološki proces	• positive regulation of receptor-mediated endocytosis; • Endocitoza; • plasma membrane tubulation; • membrane organization; • response to dietary excess; • positive regulation of feeding behavior; • clathrin-dependent endocytosis; • energy homeostasis; • clathrin coat assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	84251
	73094
	ENSG00000118473
	ENSMUSG00000028524
	Q9BQI5
	Q8VD37
NM_001308203; NM_032291; NM_001350217; NM_001350218; NM_001376534;
	NM_001376535; NM_001376536; NM_001376537; NM_001376538; NM_001376539; NM_001376540; NM_001376541; NM_001376542; NM_001376543; NM_001376544; NM_001376545; NM_001376546; NM_001376547; NM_001376548; NM_001376549; NM_001376550; NM_001376551; NM_001376552; NM_001376554; NM_001376555; NM_001376556; NM_001376557
	NM_001285852; NM_001285859; NM_001285860; NM_001285862; NM_144906
NP_001295132; NP_115667; NP_001337146; NP_001337147; NP_001363463;
	NP_001363464; NP_001363465; NP_001363466; NP_001363467; NP_001363468; NP_001363469; NP_001363470; NP_001363471; NP_001363472; NP_001363473; NP_001363474; NP_001363475; NP_001363476; NP_001363477; NP_001363478; NP_001363479; NP_001363480; NP_001363481; NP_001363483; NP_001363484; NP_001363485; NP_001363486
	NP_001272781; NP_001272788; NP_001272789; NP_001272791; NP_659155
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Interaktivni protein-3 sa 1SH3-GRB2-likim proteinom jest protein koji je kod ljudi kodiran genom SGIP1 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 828 aminokiselina, a molekulska težina 89.109 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MMEGLKKRTR	KAFGIRKKEK	DTDSTGSPDR	DGIQPSPHEP	PYNSKAECAR
EGGKKVSKKS	NGAPNGFYAE	IDWERYNSPE	LDEEGYSIRP	EEPGSTKGKH
FYSSSESEEE	EESHKKFNIK	IKPLQSKDIL	KNAATVDELK	ASIGNIALSP
SPVRKSPRRS	PGAIKRNLSS	EEVARPRRST	PTPELISKKP	PDDTTALAPL
FGPPLESAFD	EQKTEVLLDQ	PEIWGSGQPI	NPSMESPKLT	RPFPTGTPPP
LPPKNVPATP	PRTGSPLTIG	PGNDQSATEV	KIEKLPSIND	LDSIFGPVLS
PKSVAVNAEE	KWVHFSDTSP	EHVTPELTPR	EKVVSPPATP	DNPADSPAPG
PLGPPGPTGP	PGPPGPPRNV	LSPLNLEEVQ	KKVAEQTFIK	DDYLETISSP
KDFGLGQRAT	PPPPPPPTYR	TVVSSPGPGS	GPGPGTTSGA	SSPARPATPL
VPCRSTTPPP	PPPRPPSRPK	LPPGKPGVGD	VSRPFSPPIH	SSSPPPIAPL
ARAESTSSIS	STNSLSAATT	PTVENEQPSL	VWFDRGKFYL	TFEGSSRGPS
PLTMGAQDTL	PVAAAFTETV	NAYFKGADPS	KCIVKITGEM	VLSFPAGITR
HFANNPSPAA	LTFRVINFSR	LEHVLPNPQL	LCCDNTQNDA	NTKEFWVNMP
NLMTHLKKVS	EQKPQATYYN	VDMLKYQVSA	QGIQSTPLNL	AVNWRCEPSS
TDLRIDYKYN	TDAMTTAVAL	NNVQFLVPID	GGVTKLQAVL	PPAVWNAEQQ
RILWKIPDIS	QKSENGGVGS	LLARFQLSEG	PSKPSPLVVQ	FTSEGSTLSG
CDIELVGAGY	RFSLIKKRFA	AGKYLADN

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118473 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028524 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ "Entrez Gene: SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1".
^ "UniProt, Q9BQI5" (jezik: eng.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Trevaskis J, Walder K, Foletta V, et al. (2005). "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance". Endocrinology. 146 (9): 3757–64. doi:10.1210/en.2005-0282. PMID 15919751.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Uezu A, Horiuchi A, Kanda K, et al. (2007). "SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15". J. Biol. Chem. 282 (36): 26481–9. doi:10.1074/jbc.M703815200. PMID 17626015.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118473 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028524 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-6] "Entrez Gene: SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1".

[UniProt-7] "UniProt, Q9BQI5" (jezik: eng.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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