SPIN1

SPIN1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2NS2, 4H75, 4MZF, 4MZG, 4MZH
Identifikatori
Aliasi	SPIN1
Vanjski ID-jevi	OMIM: 609936 MGI: 109242 HomoloGene: 55983 GeneCards: SPIN1
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	88,478,694 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	51,306,582 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• methylated histone binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• jedro; • Diobeno vreteno; • Jedarce; • nukleoplazma; • citosol; • Jedarna membrana;
Biološki proces	• multicellular organism development; • Wnt-signalni put; • ćelijski ciklus; • GO:0007126 Mejoza; • rRNA transcription; • gamete generation; • positive regulation of Wnt signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Izvori:Amigo / QuickGO
Ortolozi
	10927
	20729
	ENSG00000106723
	ENSMUSG00000021395
	Q9Y657
	Q61142
	NM_006717
	NM_001283028; NM_001283029; NM_001283030; NM_011462; NM_146043
	NP_006708
	NP_001269957; NP_001269958; NP_001269959; NP_035592; NP_666155
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Spindlin-1 je protein koji je kod ljudi kodiran genom SPIN1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 262 aminokiseline, а molekulska težina 29.601 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKTPFGKTPG	QRSRADAGHA	GVSANMMKKR	TSHKKHRSSV	GPSKPVSQPR
RNIVGCRIQH	GWKEGNGPVT	QWKGTVLDQV	PVNPSLYLIK	YDGFDCVYGL
ELNKDERVSA	LEVLPDRVAT	SRISDAHLAD	TMIGKAVEHM	FETEDGSKDE
WRGMVLARAP	VMNTWFYITY	EKDPVLYMYQ	LLDDYKEGDL	RIMPDSNDSP
PAEREPGEVV	DSLVGKQVEY	AKEDGSKRTG	MVIHQVEAKP	SVYFIKFDDD
FHIYVYDLVK	TS

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106723 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021395 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gao Y, Yue W, Zhang P, Li L, Xie X, Yuan H, Chen L, Liu D, Yan F, Pei X (Aug 2005). "Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells". Biochem Biophys Res Commun. 335 (2): 343–50. doi:10.1016/j.bbrc.2005.07.087. PMID 16098913.
^ "Entrez Gene: SPIN1 spindlin 1".
^ "UniProt, Q9Y657". Pristupljeno 11. 9. 2021.

Dopunska literatura

Oh B, Hwang SY, Solter D, Knowles BB (1997). "Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo". Development. 124 (2): 493–503. doi:10.1242/dev.124.2.493. PMID 9053325.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Jiang F, Zhao Q, Qin L, et al. (2006). "Expression, purification, crystallization and preliminary X-ray analysis of human spindlin1, an ovarian cancer-related protein". Protein Pept. Lett. 13 (2): 203–5. doi:10.2174/092986606775101661. PMID 16472086.
Zhao Q, Qin L, Jiang F, et al. (2007). "Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation". J. Biol. Chem. 282 (1): 647–56. doi:10.1074/jbc.M604029200. PMID 17082182.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106723 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021395 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16098913-5] Gao Y, Yue W, Zhang P, Li L, Xie X, Yuan H, Chen L, Liu D, Yan F, Pei X (Aug 2005). "Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells". Biochem Biophys Res Commun. 335 (2): 343–50. doi:10.1016/j.bbrc.2005.07.087. PMID 16098913.

[entrez-6] "Entrez Gene: SPIN1 spindlin 1".

[UniProt-7] "UniProt, Q9Y657". Pristupljeno 11. 9. 2021.

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