SYCP1
Sinaptonemski kompleksni protein 1 jest protein koji je kod ljudi kodiran genom SYCP1 sa hromosoma 1. Uključen je u sinaptonemski kompleks tokom mejoze.[5][6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 976 aminokiselina, a molekulska težina 114.192 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEKQKPFALF | VPPRSSSSQV | SAVKPQTLGG | DSTFFKSFNK | CTEDDFEFPF | ||||
| AKTNLSKNGE | NIDSDPALQK | VNFLPVLEQV | GNSDCHYQEG | LKDSDLENSE | ||||
| GLSRVYSKLY | KEAEKIKKWK | VSTEAELRQK | ESKLQENRKI | IEAQRKAIQE | ||||
| LQFGNEKVSL | KLEEGIQENK | DLIKENNATR | HLCNLLKETC | ARSAEKTKKY | ||||
| EYEREETRQV | YMDLNNNIEK | MITAFEELRV | QAENSRLEMH | FKLKEDYEKI | ||||
| QHLEQEYKKE | INDKEKQVSL | LLIQITEKEN | KMKDLTFLLE | ESRDKVNQLE | ||||
| EKTKLQSENL | KQSIEKQHHL | TKELEDIKVS | LQRSVSTQKA | LEEDLQIATK | ||||
| TICQLTEEKE | TQMEESNKAR | AAHSFVVTEF | ETTVCSLEEL | LRTEQQRLEK | ||||
| NEDQLKILTM | ELQKKSSELE | EMTKLTNNKE | VELEELKKVL | GEKETLLYEN | ||||
| KQFEKIAEEL | KGTEQELIGL | LQAREKEVHD | LEIQLTAITT | SEQYYSKEVK | ||||
| DLKTELENEK | LKNTELTSHC | NKLSLENKEL | TQETSDMTLE | LKNQQEDINN | ||||
| NKKQEERMLK | QIENLQETET | QLRNELEYVR | EELKQKRDEV | KCKLDKSEEN | ||||
| CNNLRKQVEN | KNKYIEELQQ | ENKALKKKGT | AESKQLNVYE | IKVNKLELEL | ||||
| ESAKQKFGEI | TDTYQKEIED | KKISEENLLE | EVEKAKVIAD | EAVKLQKEID | ||||
| KRCQHKIAEM | VALMEKHKHQ | YDKIIEERDS | ELGLYKSKEQ | EQSSLRASLE | ||||
| IELSNLKAEL | LSVKKQLEIE | REEKEKLKRE | AKENTATLKE | KKDKKTQTFL | ||||
| LETPEIYWKL | DSKAVPSQTV | SRNFTSVDHG | ISKDKRDYLW | TSAKNTLSTP | ||||
| LPKAYTVKTP | TKPKLQQREN | LNIPIEESKK | KRKMAFEFDI | NSDSSETTDL | ||||
| LSMVSEEETL | KTLYRNNNPP | ASHLCVKTPK | KAPSSLTTPG | STLKFGAIRK | ||||
| MREDRWAVIA | KMDRKKKLKE | AEKLFV |
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000198765 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027855 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tureci O, Sahin U, Zwick C, Koslowski M, Seitz G, Pfreundschuh M (Jun 1998). "Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens". Proc Natl Acad Sci U S A. 95 (9): 5211–6. Bibcode:1998PNAS...95.5211T. doi:10.1073/pnas.95.9.5211. PMC 20240. PMID 9560255.
- ^ "Entrez Gene: SYCP1 synaptonemal complex protein 1".
- ^ "UniProt, Q15431" (jezik: eng.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dolpunska literatura
[uredi | uredi izvor]- Neumann F, Wagner C, Preuss KD, et al. (2005). "Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells". Blood. 106 (9): 3105–13. doi:10.1182/blood-2005-04-1487. PMID 16030183.
- Costa Y, Speed R, Ollinger R, et al. (2005). "Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis". J. Cell Sci. 118 (Pt 12): 2755–62. doi:10.1242/jcs.02402. PMID 15944401.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
- Kondoh N, Nishina Y, Tsuchida J, et al. (1997). "Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis". Cytogenet. Cell Genet. 78 (2): 103–4. doi:10.1159/000134637. PMID 9371398.
- Meuwissen RL, Meerts I, Hoovers JM, et al. (1997). "Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene" (PDF). Genomics. 39 (3): 377–84. doi:10.1006/geno.1996.4373. PMID 9119375.
- Meuwissen RL, Offenberg HH, Dietrich AJ, et al. (1993). "A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes". EMBO J. 11 (13): 5091–100. doi:10.1002/j.1460-2075.1992.tb05616.x. PMC 556987. PMID 1464329.