SYNJ2

SYNJ2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1UFW
Identifikatori
Aliasi	SYNJ2
Vanjski ID-jevi	OMIM: 609410 MGI: 1201671 HomoloGene: 117703 GeneCards: SYNJ2
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	158,099,176 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	6,094,565 bp
Ontologija gena
Molekularna funkcija	• phosphoric ester hydrolase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity; • vezivanje sa RNK; • nucleic acid binding; • phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; • phosphatidylinositol phosphate 4-phosphatase activity; • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; • phosphatidylinositol-3-phosphatase activity; • phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; • phosphatidylinositol phosphate 5-phosphatase activity; • inositol-polyphosphate 5-phosphatase activity; • SH3 domain binding; • PDZ domain binding; • phosphatidylinositol-4-phosphate phosphatase activity;
Ćelijska komponenta	• citoplazma; • Lipidni splav; • Akson; • citosol; • ćelijska membrana; • projekcija ćelije; • citoskelet; • membrana; • cytoplasmic microtubule; • extrinsic component of mitochondrial outer membrane; • ruffle membrane; • axon terminus; • perinuklearno područje citoplazme; • presynapse;
Biološki proces	• phosphatidylinositol biosynthetic process; • phosphatidylinositol dephosphorylation; • phosphatidylinositol-3-phosphate biosynthetic process; • membrane organization; • brain development; • inositol phosphate dephosphorylation;
	Izvori:Amigo / QuickGO
Ortolozi
	8871
	20975
	ENSG00000078269
	ENSMUSG00000023805
	O15056
	Q9D2G5
	NM_001178088; NM_003898
NM_001113351; NM_001113352; NM_001113353; NM_001290698; NM_011523;
	NM_001357665; NM_001357667
	NP_001171559; NP_003889
NP_001106822; NP_001106823; NP_001106824; NP_001277627; NP_035653;
	NP_001344594; NP_001344596
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sinaptojanin 2 jest protein koji je kod ljudi kodiran genom SYNJ2.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.496 aminokiselina, а molekulska težina 165.538 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MALSKGLRLL	GRLGAEGDCS	VLLEARGRDD	CLLFEAGTVA	TLAPEEKEVI
KGQYGKLTDA	YGCLGELRLK	SGGTSLSFLV	LVTGCTSVGR	IPDAEIYKIT
ATDFYPLQEE	AKEEERLIAL	KKILSSGVFY	FSWPNDGSRF	DLTVRTQKQG
DDSSEWGNSF	FWNQLLHVPL	RQHQVSCCDW	LLKIICGVVT	IRTVYASHKQ
AKACLVSRVS	CERTGTRFHT	RGVNDDGHVS	NFVETEQMIY	MDDGVSSFVQ
IRGSVPLFWE	QPGLQVGSHH	LRLHRGLEAN	APAFDRHMVL	LKEQYGQQVV
VNLLGSRGGE	EVLNRAFKKL	LWASCHAGDT	PMINFDFHQF	AKGGKLEKLE
TLLRPQLKLH	WEDFDVFTKG	ENVSPRFQKG	TLRMNCLDCL	DRTNTVQSFI
ALEVLHLQLK	TLGLSSKPIV	DRFVESFKAM	WSLNGHSLSK	VFTGSRALEG
KAKVGKLKDG	ARSMSRTIQS	NFFDGVKQEA	IKLLLVGDVY	GEEVADKGGM
LLDSTALLVT	PRILKAMTER	QSEFTNFKRI	RIAMGTWNVN	GGKQFRSNVL
RTAELTDWLL	DSPQLSGATD	SQDDSSPADI	FAVGFEEMVE	LSAGNIVNAS
TTNKKMWGEQ	LQKAISRSHR	YILLTSAQLV	GVCLYIFVRP	YHVPFIRDVA
IDTVKTGMGG	KAGNKGAVGI	RFQFHSTSFC	FICSHLTAGQ	SQVKERNEDY
KEITQKLCFP	MGRNVFSHDY	VFWCGDFNYR	IDLTYEEVFY	FVKRQDWKKL
LEFDQLQLQK	SSGKIFKDFH	EGAINFGPTY	KYDVGSAAYD	TSDKCRTPAW
TDRVLWWRKK	HPFDKTAGEL	NLLDSDLDVD	TKVRHTWSPG	ALQYYGRAEL
QASDHRPVLA	IVEVEVQEVD	VGARERVFQE	VSSFQGPLDA	TVVVNLQSPT
LEEKNEFPED	LRTELMQTLG	SYGTIVLVRI	NQGQMLVTFA	DSHSALSVLD
VDGMKVKGRA	VKIRPKTKDW	LKGLREEIIR	KRDSMAPVSP	TANSCLLEEN
FDFTSLDYES	EGDILEDDED	YLVDEFNQPG	VSDSELGGDD	LSDVPGPTAL
APPSKSPALT	KKKQHPTYKD	DADLVELKRE	LEAVGEFRHR	SPSRSLSVPN
RPRPPQPPQR	PPPPTGLMVK	KSASDASISS	GTHGQYSILQ	TARLLPGAPQ
QPPKARTGIS	KPYNVKQIKT	TNAQEAEAAI	RCLLEARGGA	SEEALSAVAP
RDLEASSEPE	PTPGAAKPET	PQAPPLLPRR	PPPRVPAIKK	PTLRRTGKPL
SPEEQFEQQT	VHFTIGPPET	SVEAPPVVTA	PRVPPVPKPR	TFQPGKAAER
PSHRKPASDE	APPGAGASVP	PPLEAPPLVP	KVPPRRKKSA	PAAFHLQVLQ
SNSQLLQGLT	YNSSDSPSGH	PPAAGTVFPQ	GDFLSTSSAT	SPDSDGTKAM
KPEAAPLLGD	YQDPFWNLLH	HPKLLNNTWL	SKSSDPLDSG	TRSPKRDPID
PVSAGASAAK	AELPPDHEHK	TLGHWVTISD	QEKRTALQVF	DPLAKT

Funkcija[uredi | uredi izvor]

Gen je član porodice inozitol-polifosfat 5-fosfataza. Kodirani protein stupa u interakciju sa C3 bolulin-toksinom supstratom 1 povezanim s ras, što uzrokuje translokaciju kodiranog proteina u plazmamembranu. gdje inhibira klatrin-posredovanu endocitozu. Alternativna prerada rezultira u više varijanti transkripta (prema RefSeq, maj 2010.).

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078269 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023805 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Synaptojanin 2".
^ "UniProt, O15056" (jezik: engleski). Pristupljeno 11. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Luciano M, Lopez LM, de Moor MH, Harris SE, Davies G, Nutile T, Krueger RF, Esko T, Schlessinger D, Toshiko T, Derringer JL, Realo A, Hansell NK, Pergadia ML, Pesonen AK, Sanna S, Terracciano A, Madden PA, Penninx B, Spinhoven P, Hartman CA, Oostra BA, Janssens AC, Eriksson JG, Starr JM, Cannas A, Ferrucci L, Metspalu A, Wright MJ, Heath AC, van Duijn CM, Bierut LJ, Raikkonen K, Martin NG, Ciullo M, Rujescu D, Boomsma DI, Deary IJ (mart 2012). "Longevity candidate genes and their association with personality traits in the elderly". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 159B (2): 192–200. doi:10.1002/ajmg.b.32013. PMC 3583011. PMID 22213687.
Verweij KJ, Vinkhuyzen AA, Benyamin B, Lynskey MT, Quaye L, Agrawal A, Gordon SD, Montgomery GW, Madden PA, Heath AC, Spector TD, Martin NG, Medland SE (septembar 2013). "The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation". Addiction Biology. 18 (5): 846–50. doi:10.1111/j.1369-1600.2012.00478.x. PMC 3548058. PMID 22823124.
Modregger J, Schmidt AA, Ritter B, Huttner WB, Plomann M (februar 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". The Journal of Biological Chemistry. 278 (6): 4160–7. doi:10.1074/jbc.M208568200. PMID 12456676.
Spaenij-Dekking EH, Van Delft J, Van Der Meijden E, Hiemstra HS, Falkenburg JH, Koning F, Drijfhout JW, Kluin-Nelemans JC (decembar 2003). "Synaptojanin 2 is recognized by HLA class II-restricted hairy cell leukemia-specific T cells". Leukemia. 17 (12): 2467–73. doi:10.1038/sj.leu.2403174. PMID 14562116.
Chuang Y, Xu X, Kwiatkowska A, Tsapraillis G, Hwang H, Petritis K, Flynn D, Symons M (2012). "Regulation of synaptojanin 2 5'-phosphatase activity by Src". Cell Adhesion & Migration. 6 (6): 518–25. doi:10.4161/cam.22139. PMC 3547897. PMID 23076136.
Wong KA, Wilson J, Russo A, Wang L, Okur MN, Wang X, Martin NP, Scappini E, Carnegie GK, O'Bryan JP (2012). "Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks". PLOS ONE. 7 (4): e36023. Bibcode:2012PLoSO...736023W. doi:10.1371/journal.pone.0036023. PMC 3338775. PMID 22558309.
Jiao S, Hsu L, Berndt S, Bézieau S, Brenner H, Buchanan D, Caan BJ, Campbell PT, Carlson CS, Casey G, Chan AT, Chang-Claude J, Chanock S, Conti DV, Curtis KR, Duggan D, Gallinger S, Gruber SB, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M, Hopper JL, Hudson TJ, Hutter CM, Jackson RD, Jenkins MA, Kantor ED, Kolonel LN, Küry S, Le Marchand L, Lemire M, Newcomb PA, Potter JD, Qu C, Rosse SA, Schoen RE, Schumacher FR, Seminara D, Slattery ML, Ulrich CM, Zanke BW, Peters U (2012). "Genome-wide search for gene-gene interactions in colorectal cancer". PLOS ONE. 7 (12): e52535. Bibcode:2012PLoSO...752535J. doi:10.1371/journal.pone.0052535. PMC 3530500. PMID 23300701.
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML (juli 2011). "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle". The Journal of Biological Chemistry. 286 (26): 23521–32. doi:10.1074/jbc.M111.220178. PMC 3123115. PMID 21555518.
Chuang YY, Tran NL, Rusk N, Nakada M, Berens ME, Symons M (novembar 2004). "Role of synaptojanin 2 in glioma cell migration and invasion". Cancer Research. 64 (22): 8271–5. doi:10.1158/0008-5472.CAN-04-2097. PMID 15548694.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078269 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023805 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Synaptojanin 2".

[UniProt-6] "UniProt, O15056" (jezik: engleski). Pristupljeno 11. 10. 2021.

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