THAP7

THAP7
Identifikatori
Aliasi	THAP7
Vanjski ID-jevi	OMIM: 609518 MGI: 1916259 HomoloGene: 12293 GeneCards: THAP7
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	21,002,196 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	17,349,000 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • C2H2 zinc finger domain binding; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • protein N-terminus binding; • nucleic acid binding; • vezivanje identičnih proteina; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• nuclear speck; • hromosom; • jedro; • Jedarna membrana; • intracellular membrane-bounded organelle;
Biološki proces	• GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	80764
	69009
	ENSG00000184436
	ENSMUSG00000022760
	Q9BT49
	Q8VCZ3
	NM_030573; NM_001008695; NM_001008696
	NM_026909
	NP_001008695; NP_085050
	NP_081185
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 7 sa THAP domenom jest protein koji je kod ljudi kodiran genom THAP7 sa hromosoma 22.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 309 aminokiselina, a molekulska težina 34.414 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPRHCSAAGC	CTRDTRETRN	RGISFHRLPK	KDNPRRGLWL	ANCQRLDPSG
QGLWDPASEY	IYFCSKHFEE	DCFELVGISG	YHRLKEGAVP	TIFESFSKLR
RTTKTKGHSY	PPGPAEVSRL	RRCRKRCSEG	RGPTTPFSPP	PPADVTCFPV
EEASAPATLP	ASPAGRLEPG	LSSPFSDLLG	PLGAQADEAG	CSAQPSPERQ
PSPLEPRPVS	PSAYMLRLPP	PAGAYIQNEH	SYQVGSALLW	KRRAEAALDA
LDKAQRQLQA	CKRREQRLRL	RLTKLQQERA	REKRAQADAR	QTLKEHVQDF
AMQLSSSMA

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184436 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022760 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.
^ ^a ^b "Entrez Gene: THAP7 THAP domain containing 7".

Dopunska literatura[uredi | uredi izvor]

Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Macfarlan T, Parker JB, Nagata K, Chakravarti D (2006). "Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription". Mol. Endocrinol. 20 (2): 335–47. doi:10.1210/me.2005-0248. PMID 16195249.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Macfarlan T, Kutney S, Altman B, et al. (2005). "Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor". J. Biol. Chem. 280 (8): 7346–58. doi:10.1074/jbc.M411675200. PMID 15561719.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184436 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022760 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12575992-5] Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.

[entrez-6] "Entrez Gene: THAP7 THAP domain containing 7".

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