TOE1

TOE1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2FC6
Identifikatori
Aliasi	TOE1
Vanjski ID-jevi	OMIM: 613931 MGI: 1915526 HomoloGene: 11823 GeneCards: TOE1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	45,343,973 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	116,664,837 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• 3'-5'-exoribonuclease activity; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • nucleic acid binding; • poly(A)-specific ribonuclease activity; • snRNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• citoplazma; • Cajal body; • nuclear speck; • Jedarce; • nukleoplazma; • jedro; • nuclear body;
Biološki proces	• RNA phosphodiester bond hydrolysis, exonucleolytic; • snRNA 3'-end processing; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	114034
	68276
	ENSG00000132773
	ENSMUSG00000028688
	Q96GM8
	Q9D2E2
	NM_025077
	NM_026654
	NP_079353
	NP_080930
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ciljni EGR1 protein 1 jest protein koji je kod ljudi kodiran genom TOE1 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 510 aminokiselina, a molekulska težina 56.548 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAADSDDGAV	SAPAASDGGV	SKSTTSGEEL	VVQVPVVDVQ	SNNFKEMWPS
LLLAIKTANF	VAVDTELSGL	GDRKSLLNQC	IEERYKAVCH	AARTRSILSL
GLACFKRQPD	KGEHSYLAQV	FNLTLLCMEE	YVIEPKSVQF	LIQHGFNFNQ
QYAQGIPYHK	GNDKGDESQS	QSVRTLFLEL	IRARRPLVLH	NGLIDLVFLY
QNFYAHLPES	LGTFTADLCE	MFPAGIYDTK	YAAEFHARFV	ASYLEYAFRK
CERENGKQRA	AGSPHLTLEF	CNYPSSMRDH	IDYRCCLPPA	THRPHPTSIC
DNFSAYGWCP	LGPQCPQSHD	IDLIIDTDEA	AAEDKRRRRR	RREKRKRALL
NLPGTQTSGE	AKDGPPKKQV	CGDSIKPEET	EQEVAADETR	NLPHSKQGNK
NDLEMGIKAA	RPEIADRATS	EVPGSQASPN	PVPGDGLHRA	GFDAFMTGYV
MAYVEVSQGP	QPCSSGPWLP	ECHNKVYLSG	KAVPLTVAKS	QFSRSSKAHN
QKMKLTWGSS

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132773 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028688 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi:10.1074/jbc.M210502200. PMID 12562764.
^ "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".
^ "UniProt, Q96GM8" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132773 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028688 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12562764-5] De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi:10.1074/jbc.M210502200. PMID 12562764.

[entrez-6] "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".

[UniProt-7] "UniProt, Q96GM8" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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