S Wikipedije, slobodne enciklopedije
Homolog proteina vakuoskog sortiranja 37S. cerevisiae protein koji je kod ljudi kodiran genom VPS37A .[5] endosomnog sortiranja potrebnog za transportni (ESCRT ) sistem.[6]
Dužina polipeptidnog lanca je 397 aminokiselina , а molekulska težina 44.314 Da .[7]
10 20 30 40 50 MSWLFPLTKS ASSSAAGSPG GLTSLQQQKQ RLIESLRNSH SSIAEIQKDV EYRLPFTINN LTININILLP PQFPQEKPVI SVYPPIRHHL MDKQGVYVTS PLVNNFTMHS DLGKIIQSLL DEFWKNPPVL APTSTAFPYL YSNPSGMSPY ASQGFPFLPP YPPQEANRSI TSLSVADTVS SSTTSHTTAK PAAPSFGVLS NLPLPIPTVD ASIPTSQNGF GYKMPDVPDA FPELSELSVS QLTDMNEQEE VLLEQFLTLP QLKQIITDKD DLVKSIEELA RKNLLLEPSL EAKRQTVLDK YELLTQMKST FEKKMQRQHE LSESCSASAL QARLKVAAHE AEEESDNIAE DFLEGKMEID DFLSSFMEKR TICHCRRAKE EKLQQAIAMH SQFHAPL
Pokazalo se da misens mutacija (K382N) u proteinu VPS37A uzrokuje kompleks nasljedne spazamske parapareza (cHSP). <cHSP).[8]
^ a b c GRCh38: Ensembl release 89: ENSG00000183665 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037085 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: Vacuolar protein sorting 37 homolog A (S. cerevisiae)" . Pristupljeno 20. 4. 2012 .^ Bache KG, Slagsvold T, Cabezas A, Rosendal KR, Raiborg C, Stenmark H (septembar 2004). "The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation" . Mol. Biol. Cell . 15 (9): 4337–46. doi :10.1091/mbc.E04-03-0250 . PMC 515363 PMID 15240819 . ^ "UniProt, Q8NEZ2" (jezik: engleski). Pristupljeno 22. 9. 2021 .^ Zivony-Elboum Y, Westbroek W, Kfir N, Savitzki D, Shoval Y, Bloom A, Rod R, Khayat M, Gross B, Samri W, Cohen H, Sonkin V, Freidman T, Geiger D, Fattal-Valevski A, Anikster Y, Waters AM, Kleta R, Falik-Zaccai TC (juni 2012). "A founder mutation in Vps37A causes autosomal recessive complex hereditary spastic paraparesis". J Med Genet . 49 (7): 462–72. doi :10.1136/jmedgenet-2012-100742 . PMID 22717650 . S2CID 30471834 .
Tsunematsu T, Yamauchi E, Shibata H, Maki M, Ohta T, Konishi H (2010). "Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications". Biochemical and Biophysical Research Communications . 399 (2): 232–237. doi :10.1016/j.bbrc.2010.07.060 . PMID 20654576 . Levy D, Larson MG, Benjamin EJ, Newton-Cheh C, Wang TJ, Hwang SJ, Vasan RS, Mitchell GF (2007). "Framingham Heart Study 100K Project: Genome-wide associations for blood pressure and arterial stiffness" . BMC Medical Genetics . 8 : S3. doi :10.1186/1471-2350-8-S1-S3 . PMC 1995621 PMID 17903302 . Xu Z, Liang L, Wang H, Li T, Zhao M (2003). "HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein". Biochemical and Biophysical Research Communications . 311 (4): 1057–1066. doi :10.1016/j.bbrc.2003.10.109 . PMID 14623289 . Eastman SW, Martin-Serrano J, Chung W, Zang T, Paul Bieniasz (2004). "Identification of human VPS37C, a component of ESCRT-I important for viral budding" . Journal of Biological Chemistry . 280 (1): 628–636. doi :10.1074/jbc.M410384200 PMID 15509564 . Imafuku I, Waragai M, Takeuchi S, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H (1998). "Polar Amino Acid-Rich Sequences Bind to Polyglutamine Tracts". Biochemical and Biophysical Research Communications . 253 (1): 16–20. doi :10.1006/bbrc.1998.9725 . PMID 9875212 . Stuchell MD, Garrus JE, Müller B, Stray KM, Ghaffarian S, McKinnon R, Kräusslich HG, Morham SG, Sundquist WI (2004). "The Human Endosomal Sorting Complex Required for Transport (ESCRT-I) and Its Role in HIV-1 Budding" . Journal of Biological Chemistry . 279 (34): 36059–36071. doi :10.1074/jbc.M405226200 PMID 15218037 . Lippincott-Schwartz J, Roberts TH, Hirschberg K (2000). "Secretoryproteintrafficking Andorganelledynamics Inlivingcells1" . Annual Review of Cell and Developmental Biology . 16 : 557–589. doi :10.1146/annurev.cellbio.16.1.557 . PMC 4781643 PMID 11031247 . 
