TSBP1
| TSBP1 | |||||||||||||||||||||||||
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| Aliasi | TSBP1 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 618151 HomoloGene: 81753 GeneCards: TSBP1 | ||||||||||||||||||||||||
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| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez |
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| RefSeq (mRNK) |
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| RefSeq (bjelančevina) |
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| Lokacija (UCSC) | Chr 6: 32.29 – 32.37 Mb | n/a | |||||||||||||||||||||||
| PubMed pretraga | [2] | n/a | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Membranski protein 2 na translokacijskom lancu jest protein koji je kod ljudi kodiran genom TRAM2.[3][4][5]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 370 aminokiselina, а molekulska težina 43.328 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAFRRRTKSY | PLFSQEFVIH | NHADIGFCLV | LCVLIGLMFE | VTAKTAFLFI | ||||
| LPQYNISVPT | ADSETVHYHY | GPKDLVTILF | YIFITIILHA | VVQEYILDKI | ||||
| SKRLHLSKVK | HSKFNESGQL | VVFHFTSVIW | CFYVVVTEGY | LTNPRSLWED | ||||
| YPHVHLPFQV | KFFYLCQLAY | WLHALPELYF | QKVRKEEIPR | QLQYICLYLV | ||||
| HIAGAYLLNL | SRLGLILLLL | QYSTEFLFHT | ARLFYFADEN | NEKLFSAWAA | ||||
| VFGVTRLFIL | TLAVLAIGFG | LARMENQAFD | PEKGNFNTLF | CRLCVLLLVC | ||||
| AAQAWLMWRF | IHSQLRHWRE | YWNEQSAKRR | VPATPRLPAR | LIKRESGYHE | ||||
| NGVVKAENGT | SPRTKKLKSP |
Funkcija
[uredi | uredi izvor]TRAM2 je komponenta translokona, zatvorenog makromolekulskog kanala koji kontrolira posttranslacijsku obradu nastajućih sekretornih i membranskih proteina na membrani endoplazmatskog retikuluma (ER).[5]
Reference
[uredi | uredi izvor]- 1 2 3 ENSG00000236672, ENSG00000204296, ENSG00000206310, ENSG00000234280, ENSG00000237881, ENSG00000232106, ENSG00000226892 GRCh38: Ensembl release 89: ENSG00000206245, ENSG00000236672, ENSG00000204296, ENSG00000206310, ENSG00000234280, ENSG00000237881, ENSG00000232106, ENSG00000226892 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
- ↑ Onuchic LF, Mrug M, Lakings AL, Muecher G, Becker J, Zerres K, Avner ED, Dixit M, Somlo S, Germino GG, Guay-Woodford LM (Jan 2000). "Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene". Mamm Genome. 10 (12): 1175–8. doi:10.1007/s003359901186. PMID 10594243. S2CID 11705244.
- 1 2 "Entrez Gene: TRAM2 translocation associated membrane protein 2".
- ↑ "UniProt, Q15035" (jezik: engleski). Pristupljeno 5. 10. 2021.
Dopunska literatuta
[uredi | uredi izvor]- Sudo K, Chinen K, Nakamura Y (1995). "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library". Genomics. 24 (2): 276–9. doi:10.1006/geno.1994.1616. PMID 7698749.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
- Hsu LC, Liu S, Abedinpour F, et al. (2003). "The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription". Mol. Cell. Biol. 23 (23): 8773–85. doi:10.1128/MCB.23.23.8773-8785.2003. PMC 262660. PMID 14612417.
- Stefanovic B, Stefanovic L, Schnabl B, et al. (2004). "TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis". Mol. Cell. Biol. 24 (4): 1758–68. doi:10.1128/MCB.24.4.1758-1768.2004. PMC 344171. PMID 14749390.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.