USE1

USE1
Identifikatori
Aliasi	USE1
Vanjski ID-jevi	OMIM: 610675 MGI: 1914273 HomoloGene: 10214 GeneCards: USE1
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	17,219,829 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	71,822,376 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • Lizozom; • Endoplazmatski retikulum; • membrana; • endoplasmic reticulum membrane;
Biološki proces	• lysosomal transport; • protein transport; • endoplasmic reticulum to Golgi vesicle-mediated transport; • GO:0044257 protein catabolic process; • vesicle-mediated transport; • secretion by cell; • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;
	Izvori:Amigo / QuickGO
Ortolozi
	55850
	67023
	ENSG00000053501
	ENSMUSG00000002395
	Q9NZ43
	Q9CQ56
	NM_018467
	NM_001145780; NM_025917; NM_029768
	NP_060937
	NP_001139252; NP_080193
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Neokarakterizirani hematopoietstki matični/progenitor ćelijskog proteina MDS032, znan i kao MDS032, je protein koji je kod ljudi kodiran genom MDS032.^[5]^[6]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MAASRLELNL	VRLLSRCEAM	AAEKRDPDEW	RLEKYVGALE	DMLQALKVHA
SKPASEVINE	YSWKVDFLKG	MLQAEKLTSS	SEKALANQFL	APGRVPTTAR
ERVPATKTVH	LQSRARYTSE	MRSELLGTDS	AEPEMDVRKR	TGVAGSQPVS
EKQLAAELDL	VLQRHQNLQE	KLAEEMLGLA	RSLKTNTLAA	QSVIKKDNQT
LSHSLKMADQ	NLEKLKTESE	RLEQHTQKSV	NWLLWAMLII	VCFIFISMIL
FIRIMPKLK

Funkcija

D12, mišji homolog MDS032, protein je SNARE koji je uključen u Golgijev sekretorni aparat i u endosomno-lizosomni transport.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000053501 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002395 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MDS032 uncharacterized hematopoietic stem/progenitor cells protein MDS032".
^ ^a ^b Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I (februar 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.

Dopunska literatura

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hirose H, Arasaki K, Dohmae N, et al. (2005). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Okumura AJ, Hatsuzawa K, Tamura T, et al. (2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000053501 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002395 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MDS032 uncharacterized hematopoietic stem/progenitor cells protein MDS032".

[pmid16354670-6] Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I (februar 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.

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