YY1AP1
YY1-prodruženi protein 1 jest protein koji je kod ljudi kodiran genom YY1AP1 sa hromosoma 1.[3][4]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 796 aminokiselina, a molekulska težina 87.944 Da.[5]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEEEASRSAA | ATNPGSRLTR | WPPPDKREGS | AVDPGKRRSL | AATPSSSLPC | ||||
| TLIALGLRHE | KEANELMEDL | FETFQDEMGF | SNMEDDGPEE | EERVAEPQAN | ||||
| FNTPQALRFE | ELLANLLNEQ | HQIAKELFEQ | LKMKKPSAKQ | QKEVEKVKPQ | ||||
| CKEVHQTLIL | DPAQRKRLQQ | QMQQHVQLLT | QIHLLATCNP | NLNPEASSTR | ||||
| ICLKELGTFA | QSSIALHHQY | NPKFQTLFQP | CNLMGAMQLI | EDFSTHVSID | ||||
| CSPHKTVKKT | ANEFPCLPKQ | VAWILATSKV | FMYPELLPVC | SLKAKNPQDK | ||||
| ILFTKAEDNK | YLLTCKTARQ | LTVRIKNLNM | NRAPDNIIKF | YKKTKQLPVL | ||||
| GKCCEEIQPH | QWKPPIEREE | HRLPFWLKAS | LPSIQEELRH | MADGAREVGN | ||||
| MTGTTEINSD | QGLEKDNSEL | GSETRYPLLL | PKGVVLKLKP | VADRFPKKAW | ||||
| RQKRSSVLKP | LLIQPSPSLQ | PSFNPGKTPA | QSTHSEAPPS | KMVLRIPHPI | ||||
| QPATVLQTVP | GVPPLGVSGG | ESFESPAALP | AMPPEARTSF | PLSESQTLLS | ||||
| SAPVPKVMMP | SPASSMFRKP | YVRRRPSKRR | GARAFRCIKP | APVIHPASVI | ||||
| FTVPATTVKI | VSLGGGCNMI | QPVNAAVAQS | PQTIPIATLL | VNPTSFPCPL | ||||
| NQPLVASSVS | PLIVSGNSVN | LPIPSTPEDK | AHMNVDIACA | VADGENAFQG | ||||
| LEPKLEPQEL | SPLSATVFPK | VEHSPGPPPV | DKQCQEGLSE | NSAYRWTVVK | ||||
| TEEGRQALEP | LPQGIQESLN | NSSPGDLEEV | VKMEPEDATE | EISGFL |
Funkcija[uredi | uredi izvor]
Kodirani genski proizvod vjerovatno stupa u interakciju sa proteinom YY1; međutim, njegova tačna funkcija nije poznata. Alternativna prerada rezultira višestrukim varijantama transkripta koje kodiraju različite izoforme.[4]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163374 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wang ZX, Wang HY, Wu MC (Nov 2001). "Identification and characterization of a novel human hepatocellular carcinoma-associated gene". Br J Cancer. 85 (8): 1162–7. doi:10.1054/bjoc.2001.2059. PMC 2375167. PMID 11710830.
- ^ a b "Entrez Gene: YY1AP1 YY1 associated protein 1".
- ^ "UniProt, Q9H869" (jezik: en.). Pristupljeno 8. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura[uredi | uredi izvor]
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- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Wang Z, Hu G, Wang H, Wu M (2002). "[Clone of a novel liver cancer associated gene and analysis of the secondary structures of the predicted protein]". Zhonghua Gan Zang Bing Za Zhi. 10 (1): 25–7. PMID 11856496.
- Zeng JZ, Wang HY, Chen ZJ, et al. (2002). "Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma". Oncogene. 21 (32): 4932–43. doi:10.1038/sj.onc.1205652. PMID 12118372.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Wang CY, Liang YJ, Lin YS, et al. (2004). "YY1AP, a novel co-activator of YY1". J. Biol. Chem. 279 (17): 17750–5. doi:10.1074/jbc.M310532200. PMID 14744866.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.