APLNR

S Wikipedije, slobodne enciklopedije
APLNR
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2LOT, 2LOU, 2LOV, 2LOW

Identifikatori
AliasiAPLNR
Vanjski ID-jeviOMIM: 600052 MGI: 1346086 HomoloGene: 3784 GeneCards: APLNR
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za APLNR
Genomska lokacija za APLNR
Bend11q12.1Početak57,233,577 bp[1]
Kraj57,237,250 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za APLNR
Genomska lokacija za APLNR
Bend2|2 DPočetak84,966,569 bp[2]
Kraj84,970,267 bp[2]
Ontologija gena
Molekularna funkcija G protein-coupled receptor activity
signal transducer activity
signaling receptor activity
apelin receptor activity
Ćelijska komponenta integral component of membrane
integral component of plasma membrane
membrana
Ćelijska membrana
Biološki proces multicellular organism development
heart development
regulation of body fluid levels
Gastrulacija
GO:0072468 Transdukcija signala
G protein-coupled receptor signaling pathway
negative regulation of cAMP-mediated signaling
positive regulation of angiogenesis
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of inhibitory G protein-coupled receptor phosphorylation
Vaskulogeneza
adult heart development
coronary vasculature development
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Angiogeneza
blood vessel development
apelin receptor signaling pathway
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_005161

NM_011784

RefSeq (bjelančevina)

NP_005152

NP_035914

Lokacija (UCSC)Chr 11: 57.23 – 57.24 MbChr 2: 84.97 – 84.97 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Apelinski receptor (APLNR, znan i kao APJ) je G-protein spregnuti receptor.[5] APLNR ima dva endogena liganda koji su APELIN[6][7][8] i ELABELA.[9][10] Struktura APLNR riješena je 2017.[11]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 380 aminokiselina, a molekulska težina 4.660 Da.[12].

1020304050
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVL
WTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTF
FCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVAT
AVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVG
LGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSII
VVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGH
SQGPGPNMGKGGEQMHEKSIPYSQETLVVD

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134817 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044338 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, et al. (decembar 1993). "A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11". Gene. 136 (1–2): 355–60. doi:10.1016/0378-1119(93)90495-O. PMID 8294032.
  6. ^ Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, et al. (oktobar 1998). "Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor". Biochemical and Biophysical Research Communications. 251 (2): 471–6. doi:10.1006/bbrc.1998.9489. PMID 9792798.
  7. ^ Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, et al. (januar 2000). "Characterization of apelin, the ligand for the APJ receptor". Journal of Neurochemistry. 74 (1): 34–41. doi:10.1046/j.1471-4159.2000.0740034.x. PMID 10617103. S2CID 6548112.
  8. ^ Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, et al. (septembar 2002). "Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility". Circulation Research. 91 (5): 434–40. doi:10.1161/01.RES.0000033522.37861.69. PMID 12215493.
  9. ^ Chng SC, Ho L, Tian J, Reversade B (decembar 2013). "ELABELA: a hormone essential for heart development signals via the apelin receptor". Developmental Cell. 27 (6): 672–80. doi:10.1016/j.devcel.2013.11.002. PMID 24316148.
  10. ^ Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, et al. (februar 2014). "Toddler: an embryonic signal that promotes cell movement via Apelin receptors". Science. 343 (6172): 1248636. doi:10.1126/science.1248636. PMC 4107353. PMID 24407481.
  11. ^ Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, et al. (juni 2017). "Structural Basis for Apelin Control of the Human Apelin Receptor". Structure. 25 (6): 858–866.e4. doi:10.1016/j.str.2017.04.008. PMID 28528775.
  12. ^ "UniProt, P35414". Pristupljeno 16. 8. 2021.

Dopunska literatura[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]

Šablon:G-protein spregnuti receptori