ARFGAP3

ARFGAP3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2CRW
Identifikatori
Aliasi	ARFGAP3
Vanjski ID-jevi	OMIM: 612439 MGI: 1913501 HomoloGene: 134103 GeneCards: ARFGAP3
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	42,858,106 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	83,234,448 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity;
Ćelijska komponenta	• citosol; • Golđijeva membrana; • Golđijev aparat; • membrana; • citoplazma; • endoplasmic reticulum-Golgi intermediate compartment; • trans-Golđijeva mreža; • COPI vesicle coat;
Biološki proces	• protein transport; • endoplasmic reticulum to Golgi vesicle-mediated transport; • intracellular protein transport; • vesicle-mediated transport; • protein secretion; • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • GO:0015915 transport; • COPI coating of Golgi vesicle;
	Izvori:Amigo / QuickGO
Ortolozi
	26286
	66251
	ENSG00000242247
	ENSMUSG00000054277
	Q9NP61
	Q9D8S3
	NM_001142293; NM_014570
	NM_025445; NM_001357756; NM_001357757
	NP_001135765; NP_055385
	NP_079721; NP_001344685; NP_001344686
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

ADP-ribozilacijski fator GTPazno-aktivirajući protein 3 jest protein koji je kod ljudi kodiran genom ARFGAP3 sa hromosoma 22.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 516 aminokiselina, a molekulska težina 56.928 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGDPSKQDIL	TIFKRLRSVP	TNKVCFDCGA	KNPSWASITY	GVFLCIDCSG
SHRSLGVHLS	FIRSTELDSN	WSWFQLRCMQ	VGGNASASSF	FHQHGCSTND
TNAKYNSRAA	QLYREKIKSL	ASQATRKHGT	DLWLDSCVVP	PLSPPPKEED
FFASHVSPEV	SDTAWASAIA	EPSSLTSRPV	ETTLENNEGG	QEQGPSVEGL
NVPTKATLEV	SSIIKKKPNQ	AKKGLGAKKG	SLGAQKLANT	CFNEIEKQAQ
AADKMKEQED	LAKVVSKEES	IVSSLRLAYK	DLEIQMKKDE	KMNISGKKNV
DSDRLGMGFG	NCRSVISHSV	TSDMQTIEQE	SPIMAKPRKK	YNDDSDDSYF
TSSSSYFDEP	VELRSSSFSS	WDDSSDSYWK	KETSKDTETV	LKTTGYSDRP
TARRKPDYEP	VENTDEAQKK	FGNVKAISSD	MYFGRQSQAD	YETRARLERL
SASSSISSAD	LFEEPRKQPA	GNYSLSSVLP	NAPDMAQFKQ	GVRSVAGKLS
VFANGVVTSI	QDRYGS

Funkcija[uredi | uredi izvor]

Protein kodiran ovim genom je GTPazno-aktivirajući protein (GAP) koji se povezuje sa Golgijevim aparatom i za koji se smatra da je u interakciji sa ADP-ribozilasijskim faktorom 1 (ARF1). Kodirani protein vjerovatno podstiče hidrolizahidrolizu ARF1 vezanog GTP, što je potrebno za disocijaciju proteina omotača iz Golgijski-izvedene membrane i vezikula. Disocijacija proteina omotača je preduslov za fuziju ovih vezikula sa ciljnim kompartmentima. Aktivnost ovog proteina je osjetljiva na fosfolipide. Ovaj gen je prvobitno bio poznat kao ARFGAP1, ali to je sada ime srodnog, ali različitog gena.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000242247 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054277 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang C, Yu Y, Zhang S, Liu M, Xing G, Wei H, Bi J, Liu X, Zhou G, Dong C, Hu Z, Zhang Y, Luo L, Wu C, Zhao S, He F (Jul 2000). "Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family". Genomics. 63 (3): 400–8. doi:10.1006/geno.1999.6095. PMID 10704287.
^ Liu X, Zhang C, Xing G, Chen Q, He F (Feb 2001). "Functional characterization of novel human ARFGAP3". FEBS Lett. 490 (1–2): 79–83. doi:10.1016/S0014-5793(01)02134-2. PMID 11172815. S2CID 34808599.
^ ^a ^b "Entrez Gene: ARFGAP3 ADP-ribosylation factor GTPase activating protein 3".
^ "UniProt, Q9NP61" (jezik: engleski). Pristupljeno 04-02-2022. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)

Dopunska literatura[uredi | uredi izvor]

Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma ARFGAP1 i stranica sa detaljima o genu ARFGAP1 u UCSC Genome Browseru.
Lokacija ljudskog genoma ARFGAP3 i stranica sa detaljima o genu ARFGAP3 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000242247 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054277 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10704287-5] Zhang C, Yu Y, Zhang S, Liu M, Xing G, Wei H, Bi J, Liu X, Zhou G, Dong C, Hu Z, Zhang Y, Luo L, Wu C, Zhao S, He F (Jul 2000). "Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family". Genomics. 63 (3): 400–8. doi:10.1006/geno.1999.6095. PMID 10704287.

[pmid11172815-6] Liu X, Zhang C, Xing G, Chen Q, He F (Feb 2001). "Functional characterization of novel human ARFGAP3". FEBS Lett. 490 (1–2): 79–83. doi:10.1016/S0014-5793(01)02134-2. PMID 11172815. S2CID 34808599.

[entrez-7] "Entrez Gene: ARFGAP3 ADP-ribosylation factor GTPase activating protein 3".

[UniProt-8] "UniProt, Q9NP61" (jezik: engleski). Pristupljeno 04-02-2022. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)

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