AZI2

AZI2
Identifikatori
Aliasi	AZI2
Vanjski ID-jevi	OMIM: 609916 MGI: 1351332 HomoloGene: 8443 GeneCards: AZI2
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	28,349,050 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	118,069,794 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma;
Biološki proces	• interleukin-6 production; • dendritic cell differentiation; • GO:0032617 cytokine production; • tumor necrosis factor production; • interferon-alpha production; • I-kappaB kinase/NF-kappaB signaling; • T cell activation; • dendritic cell proliferation; • GO:0007067 Mitoza; • GO:0022415 viral process;
	Izvori:Amigo / QuickGO
Ortolozi
	64343
	27215
	ENSG00000163512
	ENSMUSG00000039285
	Q9H6S1
	Q9QYP6
	NM_001134432; NM_001134433; NM_001271650; NM_022461; NM_203326
	NM_001048146; NM_001286507; NM_001286508; NM_013727
	NP_001127904; NP_001127905; NP_001258579; NP_071906
	NP_001041611; NP_001273436; NP_001273437; NP_038755
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

5-azacitidin-inducirani protein 2 jest protein koji je kod ljudi kodiran genom AZI2 sa hromosoma 3.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 392 aminokiseline, а molekulska težina 44.935 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDALVEDDIC	ILNHEKAHKR	DTVTPVSIYS	GDESVASHFA	LVTAYEDIKK
RLKDSEKENS	LLKKRIRFLE	EKLIARFEEE	TSSVGREQVN	KAYHAYREVC
IDRDNLKSKL	DKMNKDNSES	LKVLNEQLQS	KEVELLQLRT	EVETQQVMRN
LNPPSSNWEV	EKLSCDLKIH	GLEQELELMR	KECSDLKIEL	QKAKQTDPYQ
EDNLKSRDLQ	KLSISSDNMQ	HAYWELKREM	SNLHLVTQVQ	AELLRKLKTS
TAIKKACAPV	GCSEDLGRDS	TKLHLMNFTA	TYTRHPPLLP	NGKALCHTTS
SPLPGDVKVL	SEKAILQSWT	DNERSIPNDG	TCFQEHSSYG	RNSLEDNSWV
FPSPPKSSET	AFGETKTKTL	PLPNLPPLHY	LDQHNQNCLY	KN

Funkcija[uredi | uredi izvor]

AZI2, ili NAP1, doprinosi aktivaciji NFKB (vidi MIM 164011) zavisne ekspresije gena, aktiviranjem IKK-vezanih kinaza, kao što je NAK (TBK1; MIM 604834) (Fujita et al., 2003; prema OMIM-u)^[6]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163512 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039285 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene. 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID 10580148.
^ ^a ^b "Entrez Gene: AZI2 5-azacytidine induced 2".
^ "UniProt, Q9H6S1" (jezik: engleski). Pristupljeno 1. 11. 2021.

Dopunska literatura[uredi | uredi izvor]

Funami K, Sasai M, Ohba Y, et al. (2007). "Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA". J. Immunol. 179 (10): 6867–72. doi:10.4049/jimmunol.179.10.6867. PMID 17982077.
Sasai M, Shingai M, Funami K, et al. (2007). "NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction". J. Immunol. 177 (12): 8676–83. doi:10.4049/jimmunol.177.12.8676. PMID 17142768.
Sasai M, Oshiumi H, Matsumoto M, et al. (2005). "Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation". J. Immunol. 174 (1): 27–30. doi:10.4049/jimmunol.174.1.27. PMID 15611223.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Fujita F, Taniguchi Y, Kato T, et al. (2003). "Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling". Mol. Cell. Biol. 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMC 207563. PMID 14560022.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma AZI2 i stranica sa detaljima o genu AZI2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163512 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039285 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10580148-5] Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene. 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID 10580148.

[entrez-6] "Entrez Gene: AZI2 5-azacytidine induced 2".

[UniProt-7] "UniProt, Q9H6S1" (jezik: engleski). Pristupljeno 1. 11. 2021.

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