CSRP2

CSRP2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2CU8
Identifikatori
Aliasi	CSRP2
Vanjski ID-jevi	OMIM: 601871 MGI: 1202907 HomoloGene: 111061 GeneCards: CSRP2
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	76,879,023 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	110,775,483 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • molekularna funkcija; • structural constituent of muscle; • actinin binding;
Ćelijska komponenta	• jedro; • focal adhesion; • citoplazma; • Z disc;
Biološki proces	• multicellular organism development; • Ćelijska diferencijacija; • actin cytoskeleton organization; • sarcomere organization; • muscle tissue development;
	Izvori:Amigo / QuickGO
Ortolozi
	1466
	13008
	ENSG00000175183
	ENSMUSG00000020186
	Q16527
	P97314
	NM_001300965; NM_001321
	NM_007792
	NP_001287894; NP_001312
	NP_031818
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Cisteinski i glicinski bogati protein 2 je protein koji je kod ljudi kodiran genom CSRP2.^[5]

CSRP2 je član porodice gena CSRP, kodirajući grupu proteina LIM domena, koji mogu biti uključeni u regulatorne procese važne za razvoj i ćelijsku diferencijaciju. CRP2 sadrži dvije kopije motiva sekvence aminokiselina bogate cisteinom (LIM) s navodnom aktivnošću vezanja cinka i može biti uključen u regulaciju uređenog ćelijskog rasta. Ostali geni u porodici uključuju CSRP1 i CSRP3.^[6]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 193 aminokiseline, a molekulska težina 20.954 Da.^[8].

10	20	30	40	50
MPVWGGGNKC	GACGRTVYHA	EEVQCDGRSF	HRCCFLCMVC	RKNLDSTTVA
IHDEEIYCKS	CYGKKYGPKG	YGYGQGAGTL	NMDRGERLGI	KPESVQPHRP
TTNPNTSKFA	QKYGGAEKCS	RCGDSVYAAE	KIIGAGKPWH	KNCFRCAKCG
KSLESTTLTE	KEGEIYCKGC	YAKNFGPKGF	GYGQGAGALV	HAQ

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175183 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020186 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.
^ ^a ^b "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".
^ Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.
^ "UniProt, Q16527". Pristupljeno 8. 8. 2021.

Dopunska literatura[uredi | uredi izvor]

Jain MK, Fujita KP, Hsieh CM, et al. (1996). "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells". J. Biol. Chem. 271 (17): 10194–9. doi:10.1074/jbc.271.17.10194. PMID 8626582.
Karim MA, Ohta K, Egashira M, et al. (1997). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.
Weiskirchen R, Gressner AM (2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochem. Biophys. Res. Commun. 274 (3): 655–63. doi:10.1006/bbrc.2000.3187. PMID 10924333.
Weiskirchen R, Moser M, Weiskirchen S, et al. (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. doi:10.1042/0264-6021:3590485. PMC 1222169. PMID 11672422.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang M, Hu Y, Shima I, Stearns ME (2003). "IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines". Cancer Biol. Ther. 1 (5): 556–63. doi:10.4161/cbt.1.5.222. PMID 12496489.
Stearns ME, Wang M, Hu Y, Garcia FU (2004). "Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines". Mol. Cancer Res. 1 (9): 631–42. PMID 12861049.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CSRP2 i stranica sa detaljima o genu CSRP2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175183 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020186 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7499425-5] Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.

[entrez-6] "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".

[pmid9286703-7] Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.

[UniProt-8] "UniProt, Q16527". Pristupljeno 8. 8. 2021.

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