EAF2

EAF2
Identifikatori
Aliasi	EAF2
Vanjski ID-jevi	OMIM: 607659 MGI: 2146616 HomoloGene: 10208 GeneCards: EAF2
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	121,886,526 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	36,695,365 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• nuclear speck; • transcription elongation factor complex; • super elongation complex; • jedro; • nukleoplazma;
Biološki proces	• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of cell growth; • negative regulation of epithelial cell proliferation involved in prostate gland development; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • GO:0097285 apoptoza; • transcription by RNA polymerase II; • transcription elongation from RNA polymerase II promoter;
	Izvori:Amigo / QuickGO
Ortolozi
	55840
	106389
	ENSG00000145088
	ENSMUSG00000022838
	Q96CJ1
	Q91ZD6
	NM_018456; NM_001320041
	NM_001113401; NM_001113405; NM_134111; NM_001358102
	NP_001306970; NP_060926
	NP_001106872; NP_001106876; NP_598872; NP_001345031
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Elongacijski pridruženi faktor 2 jest protein koji je kod ljudi kodiran genom EAF2 sa hromosoma 3.^[5]^[6]^[7] Član je EAF porodice proteina.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 260 aminokiselina, а molekulska težina 28.792 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNSAAGFSHL	DRRERVLKLG	ESFEKQPRCA	FHTVRYDFKP	ASIDTSSEGY
LEVGEGEQVT	ITLPNIEGST	PPVTVFKGSK	KPYLKECILI	INHDTGECRL
EKLSSNITVK	KTRVEGSSKI	QYRKEQQQQQ	MWNSARTPNL	VKHSPSEDKM
SPASPIDDIE	RELKAEASLM	DQMSSCDSSS	DSKSSSSSSS	EDSSSDSEDE
DCKSSTSDTG	NCVSGHPTMT	QYRIPDIDAS	HNRFRDNSGL	LMNTLRNDLQ
LSESGSDSDD

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145088 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022838 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Simone F, Luo RT, Polak PE, Kaberlein JJ, Thirman MJ (Feb 2003). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties". Blood. 101 (6): 2355–62. doi:10.1182/blood-2002-06-1664. PMID 12446457.
^ Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z (Aug 2003). "Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer". Cancer Res. 63 (15): 4698–704. PMID 12907652.
^ "Entrez Gene: EAF2 ELL associated factor 2".
^ "UniProt, Q96CJ1" (jezik: engleski). Pristupljeno 7. 11. 2021.

Dopunska literatura

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Saso K, Ito T, Natori S, Sekimizu K (2004). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". J. Biochem. 133 (4): 493–500. doi:10.1093/jb/mvg065. PMID 12761297.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kong SE, Banks CA, Shilatifard A, et al. (2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10094–8. doi:10.1073/pnas.0503017102. PMC 1177379. PMID 16006523.
Xiao W, Jiang F, Wang Z (2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID 16114057. S2CID 32749490.
Jiang F, Ai J, Xiao W, Wang Z (2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Lett. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145088 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022838 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12446457-5] Simone F, Luo RT, Polak PE, Kaberlein JJ, Thirman MJ (Feb 2003). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties". Blood. 101 (6): 2355–62. doi:10.1182/blood-2002-06-1664. PMID 12446457.

[pmid12907652-6] Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z (Aug 2003). "Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer". Cancer Res. 63 (15): 4698–704. PMID 12907652.

[entrez-7] "Entrez Gene: EAF2 ELL associated factor 2".

[UniProt-8] "UniProt, Q96CJ1" (jezik: engleski). Pristupljeno 7. 11. 2021.

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