EDEM3

EDEM3
Identifikatori
Aliasi	EDEM3
Vanjski ID-jevi	OMIM: 610214 MGI: 1914217 HomoloGene: 11866 GeneCards: EDEM3
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	184,754,907 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	151,697,802 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• calcium ion binding; • hydrolase activity; • vezivanje iona metala; • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; • catalytic activity;
Ćelijska komponenta	• endoplasmic reticulum lumen; • Endoplazmatski retikulum; • membrana; • endoplasmic reticulum quality control compartment;
Biološki proces	• endoplasmic reticulum unfolded protein response; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • N-glycan processing; • response to unfolded protein; • glycoprotein catabolic process; • proteasome-mediated ubiquitin-dependent protein catabolic process; • mannose trimming involved in glycoprotein ERAD pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	80267
	66967
	ENSG00000116406
	ENSMUSG00000043019
	Q9BZQ6
	Q2HXL6
	NM_025191; NM_001319960
	NM_001039644; NM_001311165; NM_001311166
	NP_001306889; NP_079467
	NP_001034733; NP_001298094; NP_001298095
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

ER pojačavački protein 3 degradacije alfa-manozidaze jest enzim koji je kod ljudi kodiran genom EDEM3 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 932 aminokiselina, a molekulska težina 104.664Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSEAGGRGCG	SPVPQRARWR	LVAATAAFCL	VSATSVWTAG	AEPMSREEKQ
KLGNQVLEMF	DHAYGNYMEH	AYPADELMPL	TCRGRVRGQE	PSRGDVDDAL
GKFSLTLIDS	LDTLVVLNKT	KEFEDAVRKV	LRDVNLDNDV	VVSVFETNIR
VLGGLLGGHS	LAIMLKEKGE	YMQWYNDELL	QMAKQLGYKL	LPAFNTTSGL
PYPRINLKFG	IRKPEARTGT	ETDTCTACAG	TLILEFAALS	RFTGATIFEE
YARKALDFLW	EKRQRSSNLV	GVTINIHTGD	WVRKDSGVGA	GIDSYYEYLL
KAYVLLGDDS	FLERFNTHYD	AIMRYISQPP	LLLDVHIHKP	MLNARTWMDA
LLAFFPGLQV	LKGDIRPAIE	THEMLYQVIK	KHNFLPEAFT	TDFRVHWAQH
PLRPEFAEST	YFLYKATGDP	YYLEVGKTLI	ENLNKYARVP	CGFAAMKDVR
TGSHEDRMDS	FFLAEMFKYL	YLLFADKEDI	IFDIEDYIFT	TEAHLLPLWL
STTNQSISKK	NTTSEYTELD	DSNFDWTCPN	TQILFPNDPL	YAQSIREPLK
NVVDKSCPRG	IIRVEESFRS	GAKPPLRARD	FMATNPEHLE	ILKKMGVSLI
HLKDGRVQLV	QHAIQAASSI	DAEDGLRFMQ	EMIELSSQQQ	KEQQLPPRAV
QIVSHPFFGR	VVLTAGPAQF	GLDLSKHKET	RGFVASSKPS	NGCSELTNPE
AVMGKIALIQ	RGQCMFAEKA	RNIQNAGAIG	GIVIDDNEGS	SSDTAPLFQM
AGDGKDTDDI	KIPMLFLFSK	EGSIILDAIR	EYEEVEVLLS	DKAKDRDPEM
ENEEQPSSEN	DSQNQSGEQI	SSSSQEVDLV	DQESSEENSL	NSHPESLSLA
DMDNAASISP	SEQTSNPTEN	HETTNLNGEC	TDLDNQLQEQ	SETEEDSNPN
VSWGKKVQPI	DSILADWNED	IEAFEMMEKD	EL

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116406 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043019 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
^ Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
^ "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3".
^ "UniProt, Q9BZQ6" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Hirao K, Natsuka Y, Tamura T, et al. (2006). "EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming". J. Biol. Chem. 281 (14): 9650–8. doi:10.1074/jbc.M512191200. PMID 16431915.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116406 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043019 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15537790-5] Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.

[pmid15579471-6] Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.

[entrez-7] "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3".

[UniProt-8] "UniProt, Q9BZQ6" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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