ELOVL5

ELOVL5
Identifikatori
Aliasi	ELOVL5
Vanjski ID-jevi	OMIM: 611805 MGI: 1916051 HomoloGene: 41449 GeneCards: ELOVL5
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	53,349,179 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	77,891,801 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • aktivnost sa transferazom; • 3-oxo-arachidoyl-CoA synthase activity; • 3-oxo-cerotoyl-CoA synthase activity; • fatty acid elongase activity; • 3-oxo-lignoceronyl-CoA synthase activity; • very-long-chain 3-ketoacyl-CoA synthase activity;
Ćelijska komponenta	• dendritic tree; • dendrit; • integral component of membrane; • projekcija ćelije; • endoplasmic reticulum membrane; • neuronal cell body; • membrana; • Endoplazmatski retikulum; • integral component of endoplasmic reticulum membrane;
Biološki proces	• lipid metabolism; • fatty acid biosynthetic process; • linoleic acid metabolic process; • alpha-linolenic acid metabolic process; • fatty acid metabolic process; • unsaturated fatty acid biosynthetic process; • fatty acid elongation, polyunsaturated fatty acid; • very long-chain fatty acid biosynthetic process; • fatty acid elongation, monounsaturated fatty acid; • long-chain fatty-acyl-CoA biosynthetic process; • positive regulation of fatty acid biosynthetic process; • fatty acid elongation, saturated fatty acid; • sphingolipid biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	60481
	68801
	ENSG00000012660
	ENSMUSG00000032349
	Q9NYP7
	Q8BHI7
	NM_021814; NM_001242828; NM_001242830; NM_001242831; NM_001301856
	NM_134255
	NP_001229757; NP_001229759; NP_001229760; NP_001288785; NP_068586
	NP_599016
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 5 elongacije dugolančanih masnih kiselina jest protein koji je kod ljudi kodiran genom ELOVL5.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 299 aminokiselina, а molekulska težina 35.293 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEHFDASLST	YFKALLGPRD	TRVKGWFLLD	NYIPTFICSV	IYLLIVWLGP
KYMRNKQPFS	CRGILVVYNL	GLTLLSLYMF	CELVTGVWEG	KYNFFCQGTR
TAGESDMKII	RVLWWYYFSK	LIEFMDTFFF	ILRKNNHQIT	VLHVYHHASM
LNIWWFVMNW	VPCGHSYFGA	TLNSFIHVLM	YSYYGLSSVP	SMRPYLWWKK
YITQGQLLQF	VLTIIQTSCG	VIWPCTFPLG	WLYFQIGYMI	SLIALFTNFY
IQTYNKKGAS	RRKDHLKDHQ	NGSMAAVNGH	TNSFSPLENN	VKPRKLRKD

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000012660 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032349 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leonard AE, Bobik EG, Dorado J, Kroeger PE, Chuang LT, Thurmond JM, Parker-Barnes JM, Das T, Huang YS, Mukerji P (Jan 2001). "Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids". Biochem J. 350 Pt 3 (Pt 3): 765–70. doi:10.1042/0264-6021:3500765. PMC 1221308. PMID 10970790.
^ "Entrez Gene: ELOVL5 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)".
^ "UniProt, Q9NYP7" (jezik: engleski). Pristupljeno 2. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barragan I, Marcos I, Borrego S, Antiñolo G (2006). "Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa". Int. J. Mol. Med. 16 (6): 1163–7. doi:10.3892/ijmm.16.6.1163. PMID 16273301.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000012660 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032349 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10970790-5] Leonard AE, Bobik EG, Dorado J, Kroeger PE, Chuang LT, Thurmond JM, Parker-Barnes JM, Das T, Huang YS, Mukerji P (Jan 2001). "Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids". Biochem J. 350 Pt 3 (Pt 3): 765–70. doi:10.1042/0264-6021:3500765. PMC 1221308. PMID 10970790.

[entrez-6] "Entrez Gene: ELOVL5 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)".

[UniProt-7] "UniProt, Q9NYP7" (jezik: engleski). Pristupljeno 2. 10. 2021.

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