FAM19A1

FAM19A1
Identifikatori
Aliasi	TAFA1
Vanjski ID-jevi	OMIM: 617495 MGI: 2443695 HomoloGene: 45655 GeneCards: TAFA1
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	68,545,621 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	96,634,159 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • receptor ligand activity;
Ćelijska komponenta	• Endoplazmatski retikulum; • extracellular region; • Vanćelijsko;
Biološki proces	• regulation of signaling receptor activity; • neuroblast differentiation; • regulation of neuroblast proliferation; • GO:0072468 Transdukcija signala;
	Izvori:Amigo / QuickGO
Ortolozi
	407738
	320265
	ENSG00000183662
	ENSMUSG00000059187
	Q7Z5A9
	Q7TPG8
	NM_213609; NM_001252216
	NM_182808
	NP_001239145; NP_998774
	NP_877960
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein FAM19A1 jest protein koji je kod ljudi kodiran genom FAM19A1 sa hromosoma 3.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 133 aminokiselina, а molekulska težina 14.901 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAMVSAMSWV	LYLWISACAM	LLCHGSLQHT	FQQHHLHRPE	GGTCEVIAAH
RCCNKNRIEE	RSQTVKCSCL	PGKVAGTTRN	RPSCVDASIV	IGKWWCEMEP
CLEGEECKTL	PDNSGWMCAT	GNKIKTTRIH	PRT

Funkcija[uredi | uredi izvor]

Ovaj gen je član porodice TAFA koja se sastoji od pet visoko homolognih gena koji kodiraju male izlučene proteine. Ovi proteini sadrže konzervirane cisteinske ostatke na fiksnim pozicijama i udaljeni su srodnici sa MIP-1 alfa, članom porodice CC-hemokina. TAFA proteini su pretežno eksprimirani u specifičnim regijama mozga, a pretpostavlja se da funkcioniraju kao hemokini specifični za mozak ili neurokini koji djeluju kao regulatori imunskih i nervnih ćelija.^[6]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183662 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059187 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.
^ ^a ^b "Entrez Gene: FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1".
^ "UniProt, Q7Z5A9" (jezik: engleski). Pristupljeno 3. 11. 2021.

Dopunska literatura[uredi | uredi izvor]

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183662 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059187 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15028294-5] Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.

[entrez-6] "Entrez Gene: FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1".

[UniProt-7] "UniProt, Q7Z5A9" (jezik: engleski). Pristupljeno 3. 11. 2021.

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