GBP1

GBP1
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	1DG3, 1F5N, 2B8W, 2B92, 2BC9, 2D4H
Identifikatori
Aliasi	GBP1
Vanjski ID-jevi	OMIM: 600411 HomoloGene: 133759 GeneCards: GBP1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	89,065,360 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • Hsp90 protein binding; • spectrin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje identičnih proteina; • vezivanje enzima; • actin binding; • hydrolase activity; • GO:0019974 cytokine binding; • GO:0006184 GTPase activity; • GTP binding; • GDP binding; • protein homodimerization activity;
Ćelijska komponenta	• citosol; • membrana; • Golđijeva membrana; • ćelijska membrana; • extracellular region; • citoplazma; • Golđijev aparat; • vesicle membrane; • actin cytoskeleton; • GO:0016023 citoplazmatska vezikula;
Biološki proces	• immune system process; • interferon-gamma-mediated signaling pathway; • negative regulation of T cell receptor signaling pathway; • negative regulation of protein localization to plasma membrane; • defense response to virus; • regulation of calcium-mediated signaling; • negative regulation of ERK1 and ERK2 cascade; • negative regulation of substrate adhesion-dependent cell spreading; • regulation of protein localization to plasma membrane; • protein homooligomerization; • cellular response to interferon-gamma; • cellular response to interleukin-1; • cellular response to tumor necrosis factor; • protein localization to vacuole;
	Izvori:Amigo / QuickGO
Ortolozi
	2633
	n/a
	ENSG00000117228
	n/a
	P32455
	n/a
	NM_002053
	n/a
	NP_002044
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Interferonski-inducirani gvanilat-vezujući protein 1 jest protein koji je kod ljudi kodiran genom GBP1 sa hromosoma 1.^[3]^[4] Pripada dinaminskoj natporodici velikih GTPaza.^[5]

Amiokiselininska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 592 aminokiseline, a molekulska težina 67.931 Da.^[6].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MASEIHMTGP	MCLIENTNGR	LMANPEALKI	LSAITQPMVV	VAIVGLYRTG
KSYLMNKLAG	KKKGFSLGST	VQSHTKGIWM	WCVPHPKKPG	HILVLLDTEG
LGDVEKGDNQ	NDSWIFALAV	LLSSTFVYNS	IGTINQQAMD	QLYYVTELTH
RIRSKSSPDE	NENEVEDSAD	FVSFFPDFVW	TLRDFSLDLE	ADGQPLTPDE
YLTYSLKLKK	GTSQKDETFN	LPRLCIRKFF	PKKKCFVFDR	PVHRRKLAQL
EKLQDEELDP	EFVQQVADFC	SYIFSNSKTK	TLSGGIQVNG	PRLESLVLTY
VNAISSGDLP	CMENAVLALA	QIENSAAVQK	AIAHYEQQMG	QKVQLPTETL
QELLDLHRDS	EREAIEVFIR	SSFKDVDHLF	QKELAAQLEK	KRDDFCKQNQ
EASSDRCSAL	LQVIFSPLEE	EVKAGIYSKP	GGYRLFVQKL	QDLKKKYYEE
PRKGIQAEEI	LQTYLKSKES	MTDAILQTDQ	TLTEKEKEIE	VERVKAESAQ
ASAKMLQEMQ	RKNEQMMEQK	ERSYQEHLKQ	LTEKMENDRV	QLLKEQERTL
ALKLQEQEQL	LKEGFQKESR	IMKNEIQDLQ	TKMRRRKACT	IS

Funkcija[uredi | uredi izvor]

Gvanilatna ekspresija vezivnog proteina indukovana je interferonom. Proteini koji se vezuju za gvanilat karakteriše njihova sposobnost da specifično vežu nukleotide guanina (GMP, GDP i GTP) i razlikuju se od GTP-vezujućih proteina po prisustvu dva motiva vezivanja, a ne tri.^[4]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117228 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strehlow I, Lohmann-Matthes ML, Decker T (Aug 1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1". Gene. 144 (2): 295–9. doi:10.1016/0378-1119(94)90393-X. PMID 7518790.
^ ^a ^b "Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa".
^ Praefcke GJ, McMahon HT (februar 2004). "The dynamin superfamily: universal membrane tubulation and fission molecules?". Nat. Rev. Mol. Cell Biol. 5 (2): 133–47. doi:10.1038/nrm1313. PMID 15040446. S2CID 6305282.
^ "UniProt, P32455" (jezik: eng.). Pristupljeno 27. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects". Mol. Cell. Proteomics. 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
Naschberger E, Bauer M, Stürzl M (2006). "Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases". Adv. Enzyme Regul. 45: 215–27. doi:10.1016/j.advenzreg.2005.02.011. PMID 16005050.
Cheng YS, Patterson CE, Staeheli P (1991). "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP". Mol. Cell. Biol. 11 (9): 4717–25. doi:10.1128/MCB.11.9.4717. PMC 361367. PMID 1715024.
Nantais DE, Schwemmle M, Stickney JT, et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc. Biol. 60 (3): 423–31. doi:10.1002/jlb.60.3.423. PMID 8830800. S2CID 33727864.
Saunders NA, Smith RJ, Jetten AM (1999). "Regulation of guanylate-binding protein expression in interferon-gamma-treated human epidermal keratinocytes and squamous cell carcinoma cells". J. Invest. Dermatol. 112 (6): 977–83. doi:10.1046/j.1523-1747.1999.00611.x. PMID 10383748.
Prakash B, Praefcke GJ, Renault L, et al. (2000). "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins". Nature. 403 (6769): 567–71. Bibcode:2000Natur.403..567P. doi:10.1038/35000617. PMID 10676968. S2CID 4431592.
Kumar S, Li Q, Dua A, et al. (2001). "Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation". J. Clin. Endocrinol. Metab. 86 (6): 2420–7. doi:10.1210/jc.86.6.2420. PMID 11397834.
Guenzi E, Töpolt K, Cornali E, et al. (2001). "The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines". EMBO J. 20 (20): 5568–77. doi:10.1093/emboj/20.20.5568. PMC 125279. PMID 11598000.
Lubeseder-Martellato C, Guenzi E, Jörg A, et al. (2002). "Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases". Am. J. Pathol. 161 (5): 1749–59. doi:10.1016/S0002-9440(10)64452-5. PMC 1850787. PMID 12414522.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell. Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
Guenzi E, Töpolt K, Lubeseder-Martellato C, et al. (2003). "The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression". EMBO J. 22 (15): 3772–82. doi:10.1093/emboj/cdg382. PMC 169055. PMID 12881412.
Naschberger E, Werner T, Vicente AB, et al. (2004). "Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells". Biochem. J. 379 (Pt 2): 409–20. doi:10.1042/BJ20031873. PMC 1224089. PMID 14741045.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Praefcke GJ, Kloep S, Benscheid U, et al. (2004). "Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis". J. Mol. Biol. 344 (1): 257–69. doi:10.1016/j.jmb.2004.09.026. PMID 15504415.
Modiano N, Lu YE, Cresswell P (2005). "Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-γ-inducible cofactor". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8680–5. Bibcode:2005PNAS..102.8680M. doi:10.1073/pnas.0503227102. PMC 1150846. PMID 15937107.
Ghosh A, Praefcke GJ, Renault L, et al. (2006). "How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP". Nature. 440 (7080): 101–4. Bibcode:2006Natur.440..101G. doi:10.1038/nature04510. PMID 16511497. S2CID 4405773.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117228 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7518790-3] Strehlow I, Lohmann-Matthes ML, Decker T (Aug 1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1". Gene. 144 (2): 295–9. doi:10.1016/0378-1119(94)90393-X. PMID 7518790.

[entrez-4] "Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa".

[pmid15040446-5] Praefcke GJ, McMahon HT (februar 2004). "The dynamin superfamily: universal membrane tubulation and fission molecules?". Nat. Rev. Mol. Cell Biol. 5 (2): 133–47. doi:10.1038/nrm1313. PMID 15040446. S2CID 6305282.

[UniProt-6] "UniProt, P32455" (jezik: eng.). Pristupljeno 27. 11. 2021.CS1 održavanje: nepoznati jezik (link)

[1]

[2]

[3]

[4]

[5]

[6]