IFI27

IFI27
Identifikatori
Aliasi	IFI27
Vanjski ID-jevi	OMIM: 600009 HomoloGene: 128815 GeneCards: IFI27
Lokacija gena (čovjek)
Hrom.	Hromosom 14 (čovjek)
Kraj	94,116,695 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• lamin binding; • molekularna funkcija; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje identičnih proteina;
Ćelijska komponenta	• integral component of membrane; • mitochondrial outer membrane; • nuclear inner membrane; • membrana; • mitohondrija; • nuclear envelope; • mitochondrial membranes; • jedro; • Endoplazmatski retikulum; • endoplasmic reticulum membrane;
Biološki proces	• apoptotic signaling pathway; • GO:1901227 negative regulation of transcription by RNA polymerase II; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • type I interferon signaling pathway; • regulation of protein export from nucleus; • GO:0097285 apoptoza; • proteasome-mediated ubiquitin-dependent protein catabolic process; • modulation by host of viral genome replication; • Urođeni imunski sistem; • defense response to virus; • protein K48-linked ubiquitination; • extrinsic apoptotic signaling pathway; • immune system process; • GO:0022415 viral process;
	Izvori:Amigo / QuickGO
Ortolozi
	3429
	n/a
	ENSG00000165949; ENSG00000275214
	n/a
	P40305
	n/a
NM_005532; NM_001130080; NM_001288952; NM_001288954; NM_001288956;
	NM_001288957; NM_001288958; NM_001288959; NM_001288960; NM_001288995; NM_001366993; NM_001366994
	n/a
NP_001123552; NP_001275881; NP_001275883; NP_001275885; NP_001275886;
	NP_001275887; NP_001275888; NP_001275889; NP_001275924; NP_005523; NP_001353922; NP_001353923
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Interferonski alfa-inducibilni protein 27 je protein koji je kod ljudi kodiran genom IFI27.^[3]^[4]

Rasmussen et al. (1993) mapirali su gen IFI27 na hromosomu 14, pozicija q32, putem izotopne hibridizscije in situ.^[5]

Kloniranje i ekspresija[uredi | uredi izvor]

Rasmussen et al. (1993) izolirali su novu cDNK, koju su nazvali p27, iz ćelija karcinoma dojke tretirane estradiolom. Kodirao je navodni visoko hidrofobni protein od 122 aminokiseline, koji je imao ukupnu sličnost 33% sekvence s proizvodom interferonski induciranog proteina IFI-6-16 (IFI616). Potonji gen transkripcijski induciraju interferoni alfa i beta tipa. Pokazali su da gen IFI27 također indukuje interferon-alfa u ljudskim ćelijskim linijama različitog porijekla i da je ekspresija neovisna o prisustvu estradiolnog receptora u ćelijama.

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 119 aminokiselina, a molekulska težina 11.268 Da.^[6].

10	20	30	40	50
MEASALTSSA	VTSVAKVVRV	ASGSAVVLPL	ARIATVVIGG	VVAVPMVLSA
MGFTAAGIAS	SSIAAKMMSA	AAIANGGGVA	SGSLVATLQS	LGATGLSGLT
KFILGSIGSA	IAAVIARFY

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference[uredi | uredi izvor]

^ ^a ^b ^c ENSG00000275214 GRCh38: Ensembl release 89: ENSG00000165949, ENSG00000275214 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rasmussen UB, Wolf C, Mattei MG, Chenard MP, Bellocq JP, Chambon P, et al. (septembar 1993). "Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma". Cancer Research. 53 (17): 4096–101. PMID 8358738.
^ "Entrez Gene: IFI27 interferon, alpha-inducible protein 27".
^ Rasmussen, U. B., Wolf, C., Mattei, M.-G., Chenard, M.-P., Bellocq, J.-P., Chambon, P., Rio, M.-C., Basset, P. Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. Cancer Res. 53: 4096-4101, 1993. PubMed: 8358738
^ "UniProt, P40305". Pristupljeno 26. 7. 2021.

Dopunska literatura[uredi | uredi izvor]

Taulés M, Rius E, Talaya D, López-Girona A, Bachs O, Agell N (decembar 1998). "Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1". The Journal of Biological Chemistry. 273 (50): 33279–86. doi:10.1074/jbc.273.50.33279. PMID 9837900.
Hartley JL, Temple GF, Brasch MA (novembar 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (mart 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (septembar 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Martensen PM, Søgaard TM, Gjermandsen IM, Buttenschøn HN, Rossing AB, Bonnevie-Nielsen V, et al. (novembar 2001). "The interferon alpha induced protein ISG12 is localized to the nuclear membrane". European Journal of Biochemistry. 268 (22): 5947–54. doi:10.1046/j.0014-2956.2001.02545.x. PMID 11722583.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (februar 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
Smidt KC, Hansen LL, Søgaard TM, Petersen LK, Knudsen UB, Martensen PM (juli 2003). "A nine-nucleotide deletion and splice variation in the coding region of the interferon induced ISG12 gene". Biochimica et Biophysica Acta. 1638 (3): 227–34. doi:10.1016/s0925-4439(03)00087-5. PMID 12878323.
Parker N, Porter AC (januar 2004). "Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12". BMC Genomics. 5 (1): 8. doi:10.1186/1471-2164-5-8. PMC 343271. PMID 14728724.
Namciu SJ, Friedman RD, Marsden MD, Sarausad LM, Jasoni CL, Fournier RE (mart 2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mammalian Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (oktobar 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (januar 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Fjaerli HO, Bukholm G, Krog A, Skjaeret C, Holden M, Nakstad B (decembar 2006). "Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis". BMC Infectious Diseases. 6: 175. doi:10.1186/1471-2334-6-175. PMC 1713240. PMID 17166282.

[refGRCh38Ensembl-1] ENSG00000275214 GRCh38: Ensembl release 89: ENSG00000165949, ENSG00000275214 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8358738-3] Rasmussen UB, Wolf C, Mattei MG, Chenard MP, Bellocq JP, Chambon P, et al. (septembar 1993). "Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma". Cancer Research. 53 (17): 4096–101. PMID 8358738.

[entrez-4] "Entrez Gene: IFI27 interferon, alpha-inducible protein 27".

[5] Rasmussen, U. B., Wolf, C., Mattei, M.-G., Chenard, M.-P., Bellocq, J.-P., Chambon, P., Rio, M.-C., Basset, P. Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. Cancer Res. 53: 4096-4101, 1993. PubMed: 8358738

[UniProt-6] "UniProt, P40305". Pristupljeno 26. 7. 2021.

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