KANSL3

KANSL3
Identifikatori
Aliasi	KANSL3
Vanjski ID-jevi	OMIM: 617742 MGI: 1918055 HomoloGene: 9949 GeneCards: KANSL3
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	96,642,787 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	36,408,262 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• histone acetyltransferase activity (H4-K5 specific); • histone acetyltransferase activity (H4-K16 specific); • histone acetyltransferase activity (H4-K8 specific);
Ćelijska komponenta	• histone acetyltransferase complex; • Jedarce; • intracellular membrane-bounded organelle; • jedro; • nukleoplazma; • NSL complex;
Biološki proces	• histone H4-K16 acetylation; • histone H4-K8 acetylation; • histone H4-K5 acetylation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Izvori:Amigo / QuickGO
Ortolozi
	55683
	226976
	ENSG00000114982
	ENSMUSG00000010453
	Q9P2N6
	A2RSY1
NM_001115016; NM_017991; NM_001349256; NM_001349257; NM_001349258;
	NM_001349259; NM_001349260; NM_001349261; NM_001349262
	NM_172652; NM_001310513
NP_001108488; NP_001336185; NP_001336186; NP_001336187; NP_001336188;
	NP_001336189; NP_001336190; NP_001336191
	NP_001297442; NP_766240
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica 3 KANSL3 ili KAT8 regulatornog kompleksa NSL jest protein koji je kod ljudi kodiran genom KANSL3 sa hromosoma 2.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 904 aminokiseline, a molekulska težina 95.992 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAHRGGERDF	QTSARRMGTS	LLFQLSVHER	ELDLVFLDHS	YAKPWSAHPD
ASSARPTRML	FVTPRRQHES	TIESDVPIDV	ETVTSTPMPL	YDNQKARSVM
NECERHVIFA	RTDADAPPPP	EDWEEHVNRT	GWTMAQNKLF	NKILKALQSD
RLARLANEGA	CNEPVLRRVA	VDKCARRVRQ	ALASVSWDTK	LIQWLHTTLV
ETLSLPMLAA	YLDALQTLKG	KIPTLIDRML	VSSNTKTGAA	GAEALSLLLK
RPWDPAVGVL	SHNKPSKLPG	SPLILIASSG	PSSSVFPTSR	RHRFWQSQLS
CLGKVIPVAT	HLLNNGSGVG	VLQCLEHMIG	AVRSKVLEIH	SHFPHKPIIL
IGWNTGALVA	CHVSVMEYVT	AVVCLGFPLL	TVDGPRGDVD	DPLLDMKTPV
LFVIGQNSLQ	CHPEAMEDFR	EKIRAENSLV	VVGGADDNLR	ISKAKKKSEG
LTQSMVDRCI	QDEIVDFLTG	VLTRAEGHMG	SEPRDQDAEK	KKKPRDVARR
DLAFEVPERG	SRPASPAAKL	PASPSGSEDL	SSVSSSPTSS	PKTKVTTVTS
AQKSSQIGSS	QLLKRHVQRT	EAVLTHKQAQ	AQFAAFLKQN	MLVRKALPPG
TSSCLFVPIS	SEPPEEGEKE	DLRVQLKRHH	PSSPLPGSKT	SKRPKIKVSL
ISQGDTAGGP	CAPSQGSAPE	AAGGKPITMT	LGQASAGAKE	LTGLLTTAKS
SSSEGGVSAS	PVPSVVSSST	APSALHTLQS	RLVATSPGSS	LPGATSASSL
LQGLSFSLQD	ISSKTSGLPA	NPSPGPAPQA	TSVKLPTPMQ	SLGAITTGTS
TIVRTIPVAT	TLSSLGATPG	GKPTAIHQLL	TNGGLAKLAS	SLPGLAQISN
QASGLKVPTT	ITLTLRGQPS	RITTLSPMGS	GAAPSEESSS	QVLPSSSQRL
PPAP

Referencea[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114982 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010453 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FLJ10081 hypothetical protein FLJ10081".
^ "UniProt, Q9P2N6" (jezik: engleski). Pristupljeno 17. 11. 2021.

Dopunska literarura[uredi | uredi izvor]

Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114982 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000010453 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FLJ10081 hypothetical protein FLJ10081".

[UniProt-6] "UniProt, Q9P2N6" (jezik: engleski). Pristupljeno 17. 11. 2021.

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