MGAT5B
Alfa-1,6-manozilglikoprotein 6-beta-N-acetilglukozaminiltransferaza B je enzim koji je kod ljudi koditran genom MGAT5B.[5][6][7]
Dužina polipeptidnog lanca je 792 aminokiseline, sa molekulskom težinom od 89.535.[8]
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MITVNPDGKI | MVRRCLVTLR | PFRLFVLGIG | FFTLCFLMTS | LGGQFSARRL | ||||
| GDSPFTIRTE | VMGGPESRGV | LRKMSDLLEL | MVKRMDALAR | LENSSELHRA | ||||
| GGDLHFPADR | MPPGAGLMER | IQAIAQNVSD | IAVKVDQILR | HSLLLHSKVS | ||||
| EGRRDQCEAP | SDPKFPDCSG | KVEWMRARWT | SDPCYAFFGV | DGTECSFLIY | ||||
| LSEVEWFCPP | LPWRNQTAAQ | RAPKPLPKVQ | AVFRSNLSHL | LDLMGSGKES | ||||
| LIFMKKRTKR | LTAQWALAAQ | RLAQKLGATQ | RDQKQILVHI | GFLTEESGDV | ||||
| FSPRVLKGGP | LGEMVQWADI | LTALYVLGHG | LRVTVSLKEL | QSNLGVPPGR | ||||
| GSCPLTMPLP | FDLIYTDYHG | LQQMKRHMGL | SFKKYRCRIR | VIDTFGTEPA | ||||
| YNHEEYATLH | GYRTNWGYWN | LNPKQFMTMF | PHTPDNSFMG | FVSEELNETE | ||||
| KRLIKGGKAS | NMAVVYGKEA | SIWKLQGKEK | FLGILNKYME | IHGTVYYESQ | ||||
| RPPEVPAFVK | NHGLLPQPEF | QQLLRKAKLF | IGFGFPYEGP | APLEAIANGC | ||||
| IFLQSRFSPP | HSSLNHEFFR | GKPTSREVFS | QHPYAENFIG | KPHVWTVDYN | ||||
| NSEEFEAAIK | AIMRTQVDPY | LPYEYTCEGM | LERIHAYIQH | QDFCRAPDPA | ||||
| LPEAHAPQSP | FVLAPNATHL | EWARNTSLAP | GAWPPAHALR | AWLAVPGRAC | ||||
| TDTCLDHGLI | CEPSFFPFLN | SQDAFLKLQV | PCDSTESEMN | HLYPAFAQPG | ||||
| QECYLQKEPL | LFSCAGSNTK | YRRLCPCRDF | RKGQVALCQG | CL |
Reference
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000167889 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043857 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Inamori K, Endo T, Gu J, Matsuo I, Ito Y, Fujii S, Iwasaki H, Narimatsu H, Miyoshi E, Honke K, Taniguchi N (Jan 2004). "N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan". J Biol Chem. 279 (4): 2337–2340. doi:10.1074/jbc.C300480200. PMID 14617637.
- ↑ Kaneko M, Alvarez-Manilla G, Kamar M, Lee I, Lee JK, Troupe K, Zhang W, Osawa M, Pierce M (Nov 2003). "A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB)(1)". FEBS Lett. 554 (3): 515–519. doi:10.1016/S0014-5793(03)01234-1. PMID 14623122. S2CID 82207739.
- ↑ "Entrez Gene: MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B".
- ↑ "UniProt, Q3V5L5". Pristupljeno 12. 9. 2017.
Dopunska literatura
[uredi | uredi izvor]- Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–790. doi:10.1016/S0300-9084(01)01314-1. hdl:1874/5091. PMID 11530211.
- Abbott KL, Troupe K, Lee I, Pierce M (2006). "Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb". Exp. Cell Res. 312 (15): 2837–2850. doi:10.1016/j.yexcr.2006.05.022. PMID 16857188.
- Lee I, Guo HB, Kamar M, et al. (2006). "N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen". J. Neurochem. 97 (4): 947–956. doi:10.1111/j.1471-4159.2006.03785.x. PMID 16606368. S2CID 22339355.
- Inamori K, Mita S, Gu J, et al. (2006). "Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain". Biochim. Biophys. Acta. 1760 (4): 678–684. doi:10.1016/j.bbagen.2005.11.019. PMID 16413118.
- Guo HB, Lee I, Kamar M, Pierce M (2004). "N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways". J. Biol. Chem. 278 (52): 52412–52424. doi:10.1074/jbc.M308837200. PMID 14561752.
- Inamori K, Endo T, Ide Y, et al. (2003). "Molecular cloning and characterization of human GnT-IX, a novel beta1,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain". J. Biol. Chem. 278 (44): 43102–43109. doi:10.1074/jbc.M308255200. PMID 12941944.
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- Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–282. doi:10.1089/aid.1987.3.265. PMID 2829950.
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