MUPCDH

MUPCDH
Identifikatori
Aliasi	CDHR5
Vanjski ID-jevi	OMIM: 606839 MGI: 1919290 HomoloGene: 69345 GeneCards: CDHR5
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	626,078 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	140,856,699 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• calcium ion binding; • beta-catenin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • cell adhesion molecule binding;
Ćelijska komponenta	• integral component of membrane; • spanning component of plasma membrane; • brush border membrane; • clathrin-coated pit; • ćelijska membrana; • Egzosom; • membrana; • projekcija ćelije; • microvillus membrane; • apical plasma membrane;
Biološki proces	• Ćelijska adhezija; • regulation of microvillus length; • homophilic cell adhesion via plasma membrane adhesion molecules; • intermicrovillar adhesion; • Ćelijska diferencijacija;
	Izvori:Amigo / QuickGO
Ortolozi
	53841
	72040
	ENSG00000099834; ENSG00000273572
	ENSMUSG00000025497
	Q9HBB8
	Q8VHF2
	NM_001171968; NM_017717; NM_021924; NM_031264; NM_031265
	NM_001114322; NM_028069
	NP_001165439; NP_068743; NP_112554
	NP_001107794; NP_082345
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mucinski i kadherinoliki protein je protein koji je kod ljudi kodiran genom MUPCDH.^[5]^[6]^[7]

Ovaj gen je novi gen sličan mucinu koji je član potporodice kadherina. Dok kodiranje mucinskih nepolimorfnih tandemskih ponavljanja bogatih prolinom, serinom i s treoninom sličnih proteina, gen također sadrži sekvencu kojs kodira motive vezanja kalcija koji se nalaze u svim kadherinima. Uloga hibridne vanćelijske regije i specifična funkcija ovog proteina još nisu utvrđene. Identificiran je alternativna prerada, pri čemu je uočena varijacija rezultirala prisutnošću ili odsutnošću domena. Osim toga, dolazi do spajanja u 5' UTR-a, ali transkripti, uključujući i ove varijante nisu u potpunosti opisani.^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 845 aminokiselina, a molekulska težina 88.223 Da.^[8]

10	20	30	40	50
MGSWALLWPP	LLFTGLLVRP	PGTMAQAQYC	SVNKDIFEVE	ENTNVTEPLV
DIHVPEGQEV	TLGALSTPFA	FRIQGNQLFL	NVTPDYEEKS	LLEAQLLCQS
GGTLVTQLRV	FVSVLDVNDN	APEFPFKTKE	IRVEEDTKVN	STVIPETQLQ
AEDRDKDDIL	FYTLQEMTAG	ASDYFSLVSV	NRPALRLDRP	LDFYERPNMT
FWLLVRDTPG	ENVEPSHTAT	ATLVLNVVPA	DLRPPWFLPC	TFSDGYVCIQ
AQYHGAVPTG	HILPSPLVLR	PGPIYAEDGD	RGINQPIIYS	IFRGNVNGTF
IIHPDSGNLT	VARSVPSPMT	FLLLVKGQQA	DLARYSVTQV	TVEAVAAAGS
PPRFPQRLYR	GTVARGAGAG	VVVKDAAAPS	QPLRIQAQDP	EFSDLNSAIT
YRITNHSHFR	MEGEVVLTTT	TLAQAGAFYA	EVEAHNTVTS	GTATTVIEIQ
VSEQEPPSTD	VPPSPEAGGT	TGPWTSTTSE	VPRPPEPSQG	PSTTSSGGGT
GPHPPSGTTL	RPPTSSTPGG	PPGAENSTSH	QPATPGGDTA	QTPKPGTSQP
MPPGVGTSTS	HQPATPSGGT	AQTPEPGTSQ	PMPPSMGTST	SHQPATPGGG
TAQTPEAGTS	QPMPPGMGTS	TSHQPTTPGG	GTAQTPEPGT	SQPMPLSKST
PSSGGGPSED	KRFSVVDMAA	LGGVLGALLL	LALLGLAVLV	HKHYGPRLKC
CCGKAPEPQP	QGFDNQAFLP	DHKANWAPVP	SPTHDPKPAE	APMPAEPAPP
GPASPGGAPE	PPAAARAGGS	PTAVRSILTK	ERRPEGGYKA	VWFGEDIGTE
ADVVVLNAPT	LDVDGASDSG	SGDEGEGAGR	GGGPYDAPGG	DDSYI

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Reference

^ ^a ^b ^c ENSG00000273572 GRCh38: Ensembl release 89: ENSG00000099834, ENSG00000273572 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025497 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Paris MJ, Williams BR (Jan 2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102.
^ Goldberg M, Peshkovsky C, Shifteh A, Al-Awqati Q (Sep 2000). "mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains". J Biol Chem. 275 (32): 24622–9. doi:10.1074/jbc.M000234200. PMID 10801787. S2CID 42493271.
^ ^a ^b "Entrez Gene: MUCDHL mucin and cadherin-like".
^ "UniProt, Q9HBB8". Pristupljeno 19. 8. 2021.

Dopunska literatura

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169 (neaktivno 31. 5. 2021). PMID 10817752.CS1 održavanje: DOI nije aktivan od 2021 (link)
Goldberg M, Wei M, Tycko B, et al. (2002). "Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys". Am. J. Physiol. Renal Physiol. 283 (3): F454–63. doi:10.1152/ajprenal.00012.2002. PMID 12167596. S2CID 615952.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Goldberg M, Wei M, Yuan L, et al. (2003). "Biallelic expression of HRAS and MUCDHL in human and mouse". Hum. Genet. 112 (4): 334–42. doi:10.1007/s00439-003-0907-7. PMID 12589428. S2CID 1143721.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

[refGRCh38Ensembl-1] ENSG00000273572 GRCh38: Ensembl release 89: ENSG00000099834, ENSG00000273572 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025497 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11031102-5] Paris MJ, Williams BR (Jan 2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102.

[pmid10801787-6] Goldberg M, Peshkovsky C, Shifteh A, Al-Awqati Q (Sep 2000). "mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains". J Biol Chem. 275 (32): 24622–9. doi:10.1074/jbc.M000234200. PMID 10801787. S2CID 42493271.

[entrez-7] "Entrez Gene: MUCDHL mucin and cadherin-like".

[UniProt-8] "UniProt, Q9HBB8". Pristupljeno 19. 8. 2021.

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