NKTR
Regulatoroliki protein 2 dušik-permeaze (NPRL2) , znan i kao kandidat 4 za tumorskog supresora (TUSC4) jest protein koji je kod ljudi kodiran genom NPRL2 sa hromosoma 3.[5][6]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 380 aminokiselina, а molekulska težina Da. 43 658[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGSGCRIECI | FFSEFHPTLG | PKITYQVPED | FISRELFDTV | QVYIITKPEL | ||||
| QNKLITVTAM | EKKLIGCPVC | IEHKKYSRNA | LLFNLGFVCD | AQAKTCALEP | ||||
| IVKKLAGYLT | TLELESSFVS | MEESKQKLVP | IMTILLEELN | ASGRCTLPID | ||||
| ESNTIHLKVI | EQRPDPPVAQ | EYDVPVFTKD | KEDFFNSQWD | LTTQQILPYI | ||||
| DGFRHIQKIS | AEADVELNLV | RIAIQNLLYY | GVVTLVSILQ | YSNVYCPTPK | ||||
| VQDLVDDKSL | QEACLSYVTK | QGHKRASLRD | VFQLYCSLSP | GTTVRDLIGR | ||||
| HPQQLQHVDE | RKLIQFGLMK | NLIRRLQKYP | VRVTREEQSH | PARLYTGCHS | ||||
| YDEICCKTGM | SYHELDERLE | NDPNIIICWK |
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000114857 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032525 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lerman MI, Minna JD (Nov 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–33. PMID 11085536.
- ^ "Entrez Gene: TUSC4 tumor suppressor candidate 4".
- ^ "UniProt, Q8WTW4" (jezik: engleski). Pristupljeno 4. 11. 2021.
Dopunska literatura[uredi | uredi izvor]
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Ueda K, Kawashima H, Ohtani S, Deng WG, Ravoori M, Bankson J, Gao B, Girard L, Minna JD, Roth JA, Kundra V, Ji L (Oct 2006). "The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells". Cancer Research. 66 (19): 9682–90. doi:10.1158/0008-5472.CAN-06-1483. PMID 17018626.
- Li J, Wang F, Haraldson K, Protopopov A, Duh FM, Geil L, Kuzmin I, Minna JD, Stanbridge E, Braga E, Kashuba VI, Klein G, Lerman MI, Zabarovsky ER (Sep 2004). "Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C". Cancer Research. 64 (18): 6438–43. doi:10.1158/0008-5472.CAN-03-3869. PMID 15374952.
- Ji L, Nishizaki M, Gao B, Burbee D, Kondo M, Kamibayashi C, Xu K, Yen N, Atkinson EN, Fang B, Lerman MI, Roth JA, Minna JD (maj 2002). "Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo". Cancer Research. 62 (9): 2715–20. PMC 3478680. PMID 11980673.