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NLRP5 , skraćeno od
NOD-u sličan receptor pirinskog domena sa proteinom 5, je unutarćelijski protein koji ima ulogu u ranoj embriogenezi . To jest protein koji je kod ljudi kodiran genom NLRP5 sa q kraka hromosoma 19 .[5] [6] [7] NACHT, LRR i PYD domeni koji sadrže protein 5 (NALP5), homolog mater proteina (MATER), PYPAF8, PAN11 i CLR19.8, i jedan je od od 14 pirinskih domena koji sadrže članove porodice NOD-sličnih citoplazmatskih receptora poznatih i sisarima .[8] [9]
Dužina polipeptidnog lanca je 1.200 aminokiselina , a molekulska težina 134.342 Da .[5]
10 20 30 40 50 MKVAGGLELG AAALLSASPR ALVTLSTGPT CSILPKNPLF PQNLSSQPCI KMEGDKSLTF SSYGLQWCLY ELDKEEFQTF KELLKKKSSE STTCSIPQFE IENANVECLA LLLHEYYGAS LAWATSISIF ENMNLRTLSE KARDDMKRHS PEDPEATMTD QGPSKEKVPG ISQAVQQDSA TAAETKEQEI SQAMEQEGAT AAETEEQEIS QAMEQEGATA AETEEQGHGG DTWDYKSHVM TKFAEEEDVR RSFENTAADW PEMQTLAGAF DSDRWGFRPR TVVLHGKSGI GKSALARRIV LCWAQGGLYQ GMFSYVFFLP VREMQRKKES SVTEFISREW PDSQAPVTEI MSRPERLLFI IDGFDDLGSV LNNDTKLCKD WAEKQPPFTL IRSLLRKVLL PESFLIVTVR DVGTEKLKSE VVSPRYLLVR GISGEQRIHL LLERGIGEHQ KTQGLRAIMN NRELLDQCQV PAVGSLICVA LQLQDVVGES VAPFNQTLTG LHAAFVFHQL TPRGVVRRCL NLEERVVLKR FCRMAVEGVW NRKSVFDGDD LMVQGLGESE LRALFHMNIL LPDSHCEEYY TFFHLSLQDF CAALYYVLEG LEIEPALCPL YVEKTKRSME LKQAGFHIHS LWMKRFLFGL VSEDVRRPLE VLLGCPVPLG VKQKLLHWVS LLGQQPNATT PGDTLDAFHC LFETQDKEFV RLALNSFQEV WLPINQNLDL IASSFCLQHC PYLRKIRVDV KGIFPRDESA EACPVVPLWM RDKTLIEEQW EDFCSMLGTH PHLRQLDLGS SILTERAMKT LCAKLRHPTC KIQTLMFRNA QITPGVQHLW RIVMANRNLR SLNLGGTHLK EEDVRMACEA LKHPKCLLES LRLDCCGLTH ACYLKISQIL TTSPSLKSLS LAGNKVTDQG VMPLSDALRV SQCALQKLIL EDCGITATGC QSLASALVSN RSLTHLCLSN NSLGNEGVNL LCRSMRLPHC SLQRLMLNQC HLDTAGCGFL ALALMGNSWL THLSLSMNPV EDNGVKLLCE VMREPSCHLQ DLELVKCHLT AACCESLSCV ISRSRHLKSL DLTDNALGDG GVAALCEGLK QKNSVLARLG LKACGLTSDC CEALSLALSC NRHLTSLNLV QNNFSPKGMM KLCSAFACPT SNLQIIGLWK WQYPVQIRKL LEEVQLLKPR VVIDGSWHSF DEDDRYWWKN
^ a b c GRCh38: Ensembl release 89: ENSG00000171487 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015721 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: NLR family" .^ Wu X (februar 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)" . Hum. Reprod . 24 (2): 415–24. doi :10.1093/humrep/den403 PMID 19054779 . ^ Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (februar 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells" . J. Reprod. Dev . 56 (1): 41–8. doi :10.1262/jrd.09-098a PMID 19815987 . ^ Tong ZB, Bondy CA, Zhou J, Nelson LM (april 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development" . Hum. Reprod . 17 (4): 903–11. doi :10.1093/humrep/17.4.903 PMID 11925379 . ^ Tschopp J, Martinon F, Burns K (februar 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol . 4 (2): 95–104. doi :10.1038/nrm1019 . PMID 12563287 . S2CID 31417018 .
Maraldi T, Riccio M, Sena P, et al. (2009). "MATER protein as substrate of PKCepsilon in human cumulus cells". Mol. Hum. Reprod . 15 (8): 499–506. doi :10.1093/molehr/gap048 . PMID 19542546 . Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia" . Cancer Res . 68 (24): 10178–86. doi :10.1158/0008-5472.CAN-08-2221 PMID 19074885 . Alimohammadi M, Björklund P, Hallgren A, et al. (2008). "Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen" . N. Engl. J. Med . 358 (10): 1018–28. doi :10.1056/NEJMoa0706487 . PMID 18322283 . S2CID 6542627 . Sena P, Riccio M, Marzona L, et al. (2009). "Human MATER localization in specific cell domains of oocytes and follicular cells" . Reprod. Biomed. Online . 18 (2): 226–34. doi :10.1016/s1472-6483(10)60260-x PMID 19192343 .
Šablon:NOD-receptori
