NOB1

NOB1
Identifikatori
Aliasi	NOB1
Vanjski ID-jevi	OMIM: 613586 MGI: 1914869 HomoloGene: 31924 GeneCards: NOB1
Lokacija gena (čovjek) Hrom. Hromosom 16 (čovjek) Bend 16q22.1 Početak 69,741,871 bp Kraj 69,754,926 bp
Lokacija gena (miš) Hrom. Hromosom 8 (miš) Bend 8|8 D3 Početak 108,139,118 bp Kraj 108,151,683 bp
Ontologija gena Molekularna funkcija • vezivanje iona metala • endoribonuclease activity Ćelijska komponenta • preribosome, small subunit precursor • jedro • citosol • nukleoplazma Biološki proces • maturation of SSU-rRNA • vid • RNA phosphodiester bond hydrolysis, endonucleolytic • rRNA processing • cleavage involved in rRNA processing • ribosomal small subunit biogenesis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	28987	67619
Ensembl	ENSG00000141101	ENSMUSG00000003848
UniProt	Q9ULX3	Q8BW10
RefSeq (mRNK)	NM_014062	NM_026277
RefSeq (bjelančevina)	NP_054781	NP_080553
Lokacija (UCSC)	Chr 16: 69.74 – 69.75 Mb	Chr 8: 108.14 – 108.15 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

RNK-vezujući protein NOB1 je protein koji je kod ljudi kodiran genom NOB1.

Hartz (2010) je mapirala gen NOB1 u hromosomu, regija 16q22.1, na osnovu poravnanja sekvence NOB1 (GenBank AB026125) sa genomskom sekvencom (GRCh37).

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 412 aminokiselina, a molekulska težina 46.675 Da.

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAPVEHVVAD		AGAFLRHAAL		QDIGKNIYTI		REVVTEIRDK		ATRRRLAVLP
YELRFKEPLP		EYVRLVTEFS		KKTGDYPSLS		ATDIQVLALT		YQLEAEFVGV
SHLKQEPQKV		KVSSSIQHPE		TPLHISGFHL		PYKPKPPQET		EKGHSACEPE
NLEFSSFMFW		RNPLPNIDHE		LQELLIDRGE		DVPSEEEEEE		ENGFEDRKDD
SDDDGGGWIT		PSNIKQIQQE		LEQCDVPEDV		RVGCLTTDFA		MQNVLLQMGL
HVLAVNGMLI		REARSYILRC		HGCFKTTSDM		SRVFCSHCGN		KTLKKVSVTV
SDDGTLHMHF		SRNPKVLNPR		GLRYSLPTPK		GGKYAINPHL		TEDQRFPQLR
LSQKARQKTN		VFAPDYIAGV		SPFVENDISS		RSATLQVRDS		TLGAGRRRLN
PNASRKKFVK		KR

Dopunska literatura

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Fatica A, Oeffinger M, Dlakić M, Tollervey D (2003). "Nob1p is required for cleavage of the 3' end of 18S rRNA". Mol. Cell. Biol. 23 (5): 1798–807. doi:10.1128/MCB.23.5.1798-1807.2003. PMC 151717. PMID 12588997.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Daniele A, Altruda F, Ferrone M, et al. (1992). "Cloning and expression of a new human polypeptide which regulates protein phosphorylation in Escherichia coli". Mol. Cell. Biochem. 107 (2): 87–94. doi:10.1007/bf00225511. PMID 1791827. S2CID 25617287.