NOD1

NOD1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2B1W, 2DBD, 2NSN, 2NZ7, 4E9M, 4JQW
Identifikatori
Aliasi	NOD1
Vanjski ID-jevi	OMIM: 605980 MGI: 1341839 HomoloGene: 4440 GeneCards: NOD1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	30,478,784 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	54,949,597 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • protein homodimerization activity; • GO:0001948, GO:0016582 vezivanje za proteine; • peptidoglycan binding; • vezivanje identičnih proteina; • cysteine-type endopeptidase activator activity involved in apoptotic process; • CARD domain binding; • ATP binding; • GO:0032403 protein-containing complex binding;
Ćelijska komponenta	• citoplazma; • citosol; • membrana; • ćelijska membrana; • basolateral plasma membrane; • apical plasma membrane;
Biološki proces	• regulation of apoptotic process; • defense response; • detection of biotic stimulus; • GO:0007243 intracellular signal transduction; • positive regulation of cell death; • immune system process; • positive regulation of JNK cascade; • positive regulation of xenophagy; • positive regulation of NIK/NF-kappaB signaling; • cellular response to muramyl dipeptide; • JNK cascade; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of dendritic cell antigen processing and presentation; • positive regulation of nitric-oxide synthase activity; • defense response to bacterium; • positive regulation of NF-kappaB transcription factor activity; • protein complex oligomerization; • detection of bacterium; • positive regulation of interleukin-1 beta production; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of interleukin-6 production; • positive regulation of tumor necrosis factor production; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • inflammatory response; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • nucleotide-binding oligomerization domain containing signaling pathway; • GO:0072468 Transdukcija signala; • positive regulation of stress-activated MAPK cascade; • GO:0051637 defense response to Gram-positive bacterium; • GO:0097285 apoptoza; • Urođeni imunski sistem; • interleukin-1-mediated signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	10392
	107607
	ENSG00000106100
	ENSMUSG00000038058
	Q9Y239
	Q8BHB0
	NM_006092; NM_001354849
	NM_001171007; NM_172729
	NP_006083; NP_001341778
	NP_001164478; NP_766317
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Nukleotidnovezujući protein 1 sa domenom oligomerizacije (NOD1) jest protein koji je kod ljudi kodiran genom NOD1 sa p kraka hromosoma 7.^[5]^[6] Prepoznaje bakterijske molekule i stimulira imunsku reakciju.^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 953 aminokiseline, a molekulska težina 107.691 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEEQGHSEME	IIPSESHPHI	QLLKSNRELL	VTHIRNTQCL	VDNLLKNDYF
SAEDAEIVCA	CPTQPDKVRK	ILDLVQSKGE	EVSEFFLYLL	QQLADAYVDL
RPWLLEIGFS	PSLLTQSKVV	VNTDPVSRYT	QQLRHHLGRD	SKFVLCYAQK
EELLLEEIYM	DTIMELVGFS	NESLGSLNSL	ACLLDHTTGI	LNEQGETIFI
LGDAGVGKSM	LLQRLQSLWA	TGRLDAGVKF	FFHFRCRMFS	CFKESDRLCL
QDLLFKHYCY	PERDPEEVFA	FLLRFPHVAL	FTFDGLDELH	SDLDLSRVPD
SSCPWEPAHP	LVLLANLLSG	KLLKGASKLL	TARTGIEVPR	QFLRKKVLLR
GFSPSHLRAY	ARRMFPERAL	QDRLLSQLEA	NPNLCSLCSV	PLFCWIIFRC
FQHFRAAFEG	SPQLPDCTMT	LTDVFLLVTE	VHLNRMQPSS	LVQRNTRSPV
ETLHAGRDTL	CSLGQVAHRG	MEKSLFVFTQ	EEVQASGLQE	RDMQLGFLRA
LPELGPGGDQ	QSYEFFHLTL	QAFFTAFFLV	LDDRVGTQEL	LRFFQEWMPP
AGAATTSCYP	PFLPFQCLQG	SGPAREDLFK	NKDHFQFTNL	FLCGLLSKAK
QKLLRHLVPA	AALRRKRKAL	WAHLFSSLRG	YLKSLPRVQV	ESFNQVQAMP
TFIWMLRCIY	ETQSQKVGQL	AARGICANYL	KLTYCNACSA	DCSALSFVLH
HFPKRLALDL	DNNNLNDYGV	RELQPCFSRL	TVLRLSVNQI	TDGGVKVLSE
ELTKYKIVTY	LGLYNNQITD	VGARYVTKIL	DECKGLTHLK	LGKNKITSEG
GKYLALAVKN	SKSISEVGMW	GNQVGDEGAK	AFAEALRNHP	SLTTLSLASN
GISTEGGKSL	ARALQQNTSL	EILWLTQNEL	NDEVAESLAE	MLKVNQTLKH
LWLIQNQITA	KGTAQLADAL	QSNTGITEIC	LNGNLIKPEE	AKVYEDEKRI
ICF

Funkcija[uredi | uredi izvor]

NOD1 protein sadrži domen regrutacije kaspaze (CARD). NOD1 je član porodice proteina nodolikih receptota i blizak je srodnik NOD2. NOD1 je unutarćrlijski receptor prepoznavanja uzoraka, koji je po strukturi sličan otpornim proteinima biljaka, i posreduje urođeni i stečeni imunitet, prepoznavanjem molekula koji sadrže dio D-glutamil-mezo-diaminopimelne kiseline (iE-DAP), uključujući bakterijski peptidoglikan. Nod1 stupa u interakciju sa RIPK2 preko Card domen|CARD-a]] obiju molekula (Pogledajte strukturu NOD1 CARD na desnom panelu). Stimulacija NOD1 molekulama koji sadrže iE-DAP rezultira aktivacijom faktora transkripcije NF-κB.

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106100 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038058 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS (maj 1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". The Journal of Biological Chemistry. 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.
^ Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G (maj 1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". The Journal of Biological Chemistry. 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.
^ Mahla RS, Reddy MC, Prasad DV, Kumar H (septembar 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC 3759294. PMID 24032031.

Dopunska literatura[uredi | uredi izvor]

Martinon F, Tschopp J (august 2005). "NLRs join TLRs as innate sensors of pathogens". Trends in Immunology. 26 (8): 447–54. doi:10.1016/j.it.2005.06.004. PMID 15967716.
Strober W, Murray PJ, Kitani A, Watanabe T (januar 2006). "Signalling pathways and molecular interactions of NOD1 and NOD2". Nature Reviews. Immunology. 6 (1): 9–20. doi:10.1038/nri1747. PMID 16493424. S2CID 33505741.
Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Núñez G (septembar 2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways". The Journal of Biological Chemistry. 275 (36): 27823–31. doi:10.1074/jbc.M003415200. PMID 10880512.
Inohara N, Ogura Y, Chen FF, Muto A, Nuñez G (januar 2001). "Human Nod1 confers responsiveness to bacterial lipopolysaccharides". The Journal of Biological Chemistry. 276 (4): 2551–4. doi:10.1074/jbc.M009728200. PMID 11058605.
Chu ZL, Pio F, Xie Z, Welsh K, Krajewska M, Krajewski S, Godzik A, Reed JC (mart 2001). "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis". The Journal of Biological Chemistry. 276 (12): 9239–45. doi:10.1074/jbc.M006309200. PMID 11113115.
Yoo NJ, Park WS, Kim SY, Reed JC, Son SG, Lee JY, Lee SH (decembar 2002). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochemical and Biophysical Research Communications. 299 (4): 652–8. doi:10.1016/S0006-291X(02)02714-6. PMID 12459189.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (maj 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Stehlik C, Hayashi H, Pio F, Godzik A, Reed JC (august 2003). "CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways". The Journal of Biological Chemistry. 278 (34): 31941–9. doi:10.1074/jbc.M300009200. PMID 12775719.
Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jéhanno M, Viala J, Tedin K, Taha MK, Labigne A, Zähringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ (juni 2003). "Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan". Science. 300 (5625): 1584–7. Bibcode:2003Sci...300.1584G. doi:10.1126/science.1084677. PMID 12791997. S2CID 1320864.
Hisamatsu T, Suzuki M, Podolsky DK (august 2003). "Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells". The Journal of Biological Chemistry. 278 (35): 32962–8. doi:10.1074/jbc.M304355200. PMID 12813035.
Girardin SE, Travassos LH, Hervé M, Blanot D, Boneca IG, Philpott DJ, Sansonetti PJ, Mengin-Lecreulx D (oktobar 2003). "Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2". The Journal of Biological Chemistry. 278 (43): 41702–8. doi:10.1074/jbc.M307198200. PMID 12871942.
Kim JG, Lee SJ, Kagnoff MF (mart 2004). "Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors". Infection and Immunity. 72 (3): 1487–95. doi:10.1128/IAI.72.3.1487-1495.2004. PMC 356064. PMID 14977954.
Damiano JS, Oliveira V, Welsh K, Reed JC (juli 2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses". The Biochemical Journal. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMC 1133779. PMID 15107016.

Vanjski linkovi[uredi | uredi izvor]

NOD1 lokacija ljudskog genoma UCSC Genome Browser.

NOD1 detalji ljudskog genoma u UCSC Genome Browser.

Šablon:Nodoliki receptori

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106100 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038058 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10224040-5] Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS (maj 1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". The Journal of Biological Chemistry. 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.

[pmid10329646-6] Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G (maj 1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". The Journal of Biological Chemistry. 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.

[7] Mahla RS, Reddy MC, Prasad DV, Kumar H (septembar 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC 3759294. PMID 24032031.

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