S Wikipedije, slobodne enciklopedije
Jedarčani protein 12protein koji je kod ljudi kodiran genom NOL12 sa hromosoma 22 .[5] [6]
Dužina polipeptidnog lanca je 213 aminokiseline , a molekulska težina 24.663 Da .[6]
10 20 30 40 50 MGRNKKKKRD GDDRRPRLVL SFDEEKRREY LTGFHKRKVE RKKAAIEEIK QRLKEEQRKL REERHQEYLK MLAEREEALE EADELDRLVT AKTESVQYDH PNHTVTVTTI SDLDLSGARL LGLTPPEGGA GDRSEEEASS TEKPTKALPR KSRDPLLSQR ISSLTASLHA HSRKKVKRKH PRRAQDSKKP PRAPRTSKAQ RRRLTGKARH SGE
Pokazalo se da se ljudskii NOL12 nalazi u jedarcetuu i reguliše jedarčanu strukturu i homeostazu , održavanjem nivoa multifunkcionalnih fibrilarinskih i nukleolinskih proteina. Njegov nedostatak dovodi do aktivacije p53 , što rezultira zaustavljanjem ćelijskog ciklusa u njgovoj fazi G2 . Nol12 ili hNol12 pokreću p53 indukovano starenje ćelija sugerišući njegovu važnu ulogu u starenju .[7] ribosoma i integritet genoma .[8]
Ljudski Nol12 pripada porodici proteina poznatih kao ribosomski vezujući proteini RBP-i. Ljudski članovi imaju ekvivalente u različitim vrstama . Njegov homolog u Drosophila melanogaster Viriato , koji je uključen u razvoj očiju i nervnog sistema i bez njega, kod Drosophila melanogaster proliferacijom ćelija , kašnjenjem u razvoju i apoptozama .[9] [10] [11] egzonukleaznu aktivnost i da je uključen u biogenezu ribosoma .[12]
^ a b c GRCh38: Ensembl release 89: ENSG00000273899 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033099 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proceedings of the National Academy of Sciences of the United States of America . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . ^ a b "Entrez Gene: NOL12 nucleolar protein 12" .^ Pinho M, Macedo JC, Logarinho E, Pereira PS (June 2019). "NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging" . Molecular and Cellular Biology . 39 (12). doi :10.1128/MCB.00099-19 . PMC 6549468 PMID 30988155 . ^ Scott DD, Trahan C, Zindy PJ, Aguilar LC, Delubac MY, Van Nostrand EL, et al. (December 2017). "Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism" . Nucleic Acids Research . 45 (21): 12509–12528. doi :10.1093/nar/gkx963 PMC 5716212 PMID 29069457 . ^ Marinho J, Martins T, Neto M, Casares F, Pereira PS (May 2013). "The nucleolar protein Viriato/Nol12 is required for the growth and differentiation progression activities of the Dpp pathway during Drosophila eye development" . Developmental Biology . 377 (1): 154–65. doi :10.1016/j.ydbio.2013.02.003 PMID 23416177 . ^ Marinho J, Casares F, Pereira PS (January 2011). "The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth" . Development . 138 (2): 349–57. doi :10.1242/dev.054411 PMID 21177347 . S2CID 18287789 . ^ Suzuki S, Fujiwara T, Kanno M (July 2007). "Nucleolar protein Nop25 is involved in nucleolar architecture". Biochemical and Biophysical Research Communications . 358 (4): 1114–9. doi :10.1016/j.bbrc.2007.05.069 . PMID 17524363 . ^ Oeffinger M, Zenklusen D, Ferguson A, Wei KE, El Hage A, Tollervey D, et al. (December 2009). "Rrp17p is a eukaryotic exonuclease required for 5' end processing of Pre-60S ribosomal RNA" . Molecular Cell . 36 (5): 768–81. doi :10.1016/j.molcel.2009.11.011 . PMC 2806520 PMID 20005841 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle" . Proceedings of the National Academy of Sciences of the United States of America . 103 (14): 5391–6. Bibcode :2006PNAS..103.5391N . doi :10.1073/pnas.0507066103 PMC 1459365 PMID 16565220 . Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biology . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 . PMC 545604 PMID 15461802 . Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, et al. (January 2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22" . Genome Research . 13 (1): 27–36. doi :10.1101/gr.695703 . PMC 430954 PMID 12529303 . Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. Bibcode :1999Natur.402..489D . doi :10.1038/990031 PMID 10591208 . 
