S Wikipedije, slobodne enciklopedije
NPW jegen koji ko ljudi kodoira protein zvani neuropeptid W .[5] [6] [7]
Neuropeptid W (NPW) je endogeni peptidni ligand za GPR8 (MIM 600731), receptor vezan za G-protein (prema OMIM [7]
Dužina polipeptidnog lanca je 165 aminokiselina , a molekulska težina 18.048 Da .[8]
Simboli
10 20 30 40 50 MAWRPGERGA PASRPRLALL LLLLLLPLPS GAWYKHVASP RYHTVGRAAG LLMGLRRSPY LWRRALRAAA GPLARDTLSP EPAAREAPLL LPSWVQELWE TRRRSSQAGI PVRAPRSPRA PEPALEPESL DFSGAGQRLR RDVSRPAVDP AANRLGLPCL APGPF
^ a b c GRCh38: Ensembl release 89: ENSG00000183971 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071230 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M (Sep 2002). "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7" . J Biol Chem . 277 (37): 34010–6. doi :10.1074/jbc.M205883200 PMID 12118011 . ^ Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M (Jan 2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8" . J Biol Chem . 278 (2): 776–83. doi :10.1074/jbc.M206396200 PMID 12401809 . ^ a b "Entrez Gene: NPW neuropeptide W" .^ "UniProt, Q8N729" . Pristupljeno 8. 7. 2021 .
Singh G, Davenport AP (2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system" . Br. J. Pharmacol . 148 (8): 1033–41. doi :10.1038/sj.bjp.0706825 . PMC 1752024 PMID 16847439 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8" . J. Biol. Chem . 277 (39): 35826–32. doi :10.1074/jbc.M205337200 PMID 12130646 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8" . Proc. Natl. Acad. Sci. U.S.A . 100 (10): 6251–6. doi :10.1073/pnas.0837789100 . PMC 156358 PMID 12719537 . Mondal MS, Yamaguchi H, Date Y, et al. (2003). "A role for neuropeptide W in the regulation of feeding behavior" . Endocrinology . 144 (11): 4729–33. doi :10.1210/en.2003-0536 PMID 12959997 . Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades" . J. Clin. Endocrinol. Metab . 90 (6): 3466–71. doi :10.1210/jc.2004-2132 PMID 15797961 . Andreis PG, Rucinski M, Neri G, et al. (2006). "Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects". Int. J. Mol. Med . 16 (6): 1021–8. doi :10.3892/ijmm.16.6.1021 . PMID 16273281 . Mondal MS, Yamaguchi H, Date Y, et al. (2006). "Neuropeptide W is present in antral G cells of rat, mouse, and human stomach" . J. Endocrinol . 188 (1): 49–57. doi :10.1677/joe.1.06195 PMID 16394174 . 
