PHAX

PHAX
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2XC7
Identifikatori
Aliasi	PHAX
Vanjski ID-jevi	OMIM: 604924 MGI: 1891839 HomoloGene: 10558 GeneCards: PHAX
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	126,627,252 bp
Lokacija gena (miš)
Hrom.	Hromosom 18 (miš)
Kraj	56,720,784 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • toxic substance binding; • vezivanje sa RNK;
Ćelijska komponenta	• nukleoplazma; • Cajal body; • jedro; • citosol; • soma; • citoplazma; • centrosom;
Biološki proces	• protein transport; • snRNA export from nucleus; • snRNA transcription by RNA polymerase II; • nuclear export;
	Izvori:Amigo / QuickGO
Ortolozi
	51808
	56698
	ENSG00000164902
	ENSMUSG00000008301
	Q9H814
	Q9JJT9
	NM_032177
	NM_001162989; NM_019996
	NP_115553
	NP_001156461; NP_064380
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Eksportni protein fosforiliziranog adaptera RNK jest protein koji je kod ljudi kodiran genom PHAX sa hromosoma 5.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 394 aminokiseline, а molekulska težina 44.403 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MALEVGDMED	GQLSDSDSDM	TVAPSDRPLQ	LPKVLGGDSA	MRAFQNTATA
CAPVSHYRAV	ESVDSSEESF	SDSDDDSCLW	KRKRQKCFNP	PPKPEPFQFG
QSSQKPPVAG	GKKINNIWGA	VLQEQNQDAV	ATELGILGME	GTIDRSRQSE
TYNYLLAKKL	RKESQEHTKD	LDKELDEYMH	GGKKMGSKEE	ENGQGHLKRK
RPVKDRLGNR	PEMNYKGRYE	ITAEDSQEKV	ADEISFRLQE	PKKDLIARVV
RIIGNKKAIE	LLMETAEVEQ	NGGLFIMNGS	RRRTPGGVFL	NLLKNTPSIS
EEQIKDIFYI	ENQKEYENKK	AARKRRTQVL	GKKMKQAIKS	LNFQEDDDTS
RETFASDTNE	ALASLDESQE	GHAEAKLEAE	EAIEVDHSHD	LDIF

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000164902 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008301 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ohno M, Segref A, Bachi A, Wilm M, Mattaj IW (maj 2000). "PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation". Cell. 101 (2): 187–98. doi:10.1016/S0092-8674(00)80829-6. PMID 10786834. S2CID 8938256.
↑ "Entrez Gene: RNUXA RNA U, small nuclear RNA export adaptor (phosphorylation regulated)".
↑ "UniProt, Q9H814" (jezik: engleski). Pristupljeno 18. 10. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Segref A, Mattaj IW, Ohno M (2001). "The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export". RNA. 7 (3): 351–60. doi:10.1017/S1355838201002278. PMC 1370092. PMID 11333016.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Boulon S, Verheggen C, Jady BE, et al. (2005). "PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli". Mol. Cell. 16 (5): 777–87. doi:10.1016/j.molcel.2004.11.013. PMID 15574332.
Watkins NJ, Lemm I, Ingelfinger D, et al. (2005). "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex". Mol. Cell. 16 (5): 789–98. doi:10.1016/j.molcel.2004.11.012. hdl:11858/00-001M-0000-0012-EB89-8. PMID 15574333.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164902 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008301 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10786834-5] Ohno M, Segref A, Bachi A, Wilm M, Mattaj IW (maj 2000). "PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation". Cell. 101 (2): 187–98. doi:10.1016/S0092-8674(00)80829-6. PMID 10786834. S2CID 8938256.

[entrez-6] "Entrez Gene: RNUXA RNA U, small nuclear RNA export adaptor (phosphorylation regulated)".

[UniProt-7] "UniProt, Q9H814" (jezik: engleski). Pristupljeno 18. 10. 2021.

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