S Wikipedije, slobodne enciklopedije
RNK -vezujući protein 6protein koji je kod ljudi kodiran genom RBM6 sa hromosoma 3 .[ 5] [ 6] RBM6 ortolozi [ 7] sisara za koje su dostupni potpuni podaci o genomu .
Dužina polipeptidnog lanca je 1.123 aminokiseline , а molekulska težina 128.644 Da .[ 8]
10 20 30 40 50 MWGDSRPANR TGPFRGSQEE RFAPGWNRDY PPPPLKSHAQ ERHSGNFPGR DSLPFDFQGH SGPPFANVEE HSFSYGARDG PHGDYRGGEG PGHDFRGGDF SSSDFQSRDS SQLDFRGRDI HSGDFRDREG PPMDYRGGDG TSMDYRGREA PHMNYRDRDA HAVDFRGRDA PPSDFRGRGT YDLDFRGRDG SHADFRGRDL SDLDFRAREQ SRSDFRNRDV SDLDFRDKDG TQVDFRGRGS GTTDLDFRDR DTPHSDFRGR HRSRTDQDFR GREMGSCMEF KDREMPPVDP NILDYIQPST QDREHSGMNV NRREESTHDH TIERPAFGIQ KGEFEHSETR EGETQGVAFE HESPADFQNS QSPVQDQDKS QLSGREEQSS DAGLFKEEGG LDFLGRQDTD YRSMEYRDVD HRLPGSQMFG YGQSKSFPEG KTARDAQRDL QDQDYRTGPS EEKPSRLIRL SGVPEDATKE EILNAFRTPD GMPVKNLQLK EYNTGYDYGY VCVEFSLLED AIGCMEANQG TLMIQDKEVT LEYVSSLDFW YCKRCKANIG GHRSSCSFCK NPREVTEAKQ ELITYPQPQK TSIPAPLEKQ PNQPLRPADK EPEPRKREEG QESRLGHQKR EAERYLPPSR REGPTFRRDR ERESWSGETR QDGESKTIML KRIYRSTPPE VIVEVLEPYV RLTTANVRII KNRTGPMGHT YGFIDLDSHA EALRVVKILQ NLDPPFSIDG KMVAVNLATG KRRNDSGDHS DHMHYYQGKK YFRDRRGGGR NSDWSSDTNR QGQQSSSDCY IYDSATGYYY DPLAGTYYDP NTQQEVYVPQ DPGLPEEEEI KEKKPTSQGK SSSKKEMSKR DGKEKKDRGV TRFQENASEG KAPAEDVFKK PLPPTVKKEE SPPPPKVVNP LIGLLGEYGG DSDYEEEEEE EQTPPPQPRT AQPQKREEQT KKENEEDKLT DWNKLACLLC RRQFPNKEVL IKHQQLSDLH KQNLEIHRKI KQSEQELAYL ERREREGKFK GRGNDRREKL QSFDSPERKR IKYSRETDSD RKLVDKEDID TSSKGGCVQQ ATGWRKGTGL GYGHPGLASS EEAEGRMRGP SVGASGRTSK RQSNETYRDA VRRVMFARYK ELD
^ a b c GRCh38: Ensembl release 89: ENSG00000004534 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032582 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Voutsinas G, Hulsbeek MM, Draaijers TG, Looman MW, Kok K, Naylor SL, Buys CH (Aug 1999). "A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3" . Eur J Hum Genet . 7 (4): 478–86. doi :10.1038/sj.ejhg.5200334 PMID 10352938 . ^ "Entrez Gene: RBM6 RNA binding motif protein 6" .^ "OrthoMaM phylogenetic marker: RBM6 coding sequence" . Arhivirano s originala , 3. 3. 2016. Pristupljeno 5. 11. 2021 .^ "UniProt, P78332" (jezik: engleski). Pristupljeno 5. 11. 2021 .
Güre AO, Altorki NK, Stockert E, et al. (1998). "Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res . 58 (5): 1034–41. PMID 9500467 . Drabkin HA, West JD, Hotfilder M, et al. (1999). "DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC" . Oncogene . 18 (16): 2589–97. doi :10.1038/sj.onc.1202601 PMID 10353602 . Timmer T, Terpstra P, van den Berg A, et al. (1999). "An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers". Genomics . 60 (2): 238–40. doi :10.1006/geno.1999.5878 . PMID 10486216 . Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res . 60 (21): 6116–33. PMID 11085536 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization" . Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Gu TL, Mercher T, Tyner JW, et al. (2007). "A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia" . Blood . 110 (1): 323–33. doi :10.1182/blood-2006-10-052282 . PMC 1896120 PMID 17360941 . Wang K, Ubriaco G, Sutherland LC (2007). "RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours" . BMC Genomics . 8 : 348. doi :10.1186/1471-2164-8-348 . PMC 2174484 PMID 17908320 .
RBM6 UCSC Genome Browser .
