SEBOX
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| Vanjski ID-jevi | OMIM: 610975 MGI: 108012 HomoloGene: 32052 GeneCards: SEBOX | ||||||||||||||||||||||||
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| Vrste | Čovjek | Miš | |||||||||||||||||||||||
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| Lokacija (UCSC) | Chr 17: 28.36 – 28.37 Mb | Chr 11: 78.39 – 78.4 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
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Alfa-N-acetilgalaktosaminid alfa-2,6-sialiltransferaza 2 je enzim koji je kod ljudi kodiran genom ST6GALNAC2.[5][6]
Dužina polipeptidnog lanca je 374 aminokiseline, a molekulska težina 41.939.[7].
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGLPRGSFFW | LLLLLTAACS | GLLFALYFSA | VQRYPGPAAG | ARDTTSFEAF | ||||
| FQSKASNSWT | GKGQACRHLL | HLAIQRHPHF | RGLFNLSIPV | LLWGDLFTPA | ||||
| LWDRLSQHKA | PYGWRGLSHQ | VIASTLSLLN | GSESAKLFAP | PRDTPPKCIR | ||||
| CAVVGNGGIL | NGSRQGPNID | AHDYVFRLNG | AVIKGFERDV | GTKTSFYGFT | ||||
| VNTMKNSLVS | YWNLGFTSVP | QGQDLQYIFI | PSDIRDYVML | RSAILGVPVP | ||||
| EGLDKGDRPH | AYFGPEASAS | KFKLLHPDFI | SYLTERFLKS | KLINTHFGDL | ||||
| YMPSTGALML | LTALHTCDQV | SAYGFITSNY | WKFSDHYFER | KMKPLIFYAN | ||||
| HDLSLEAALW | RDLHKAGILQ | LYQR |
Reference
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000274529 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001103 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Sotiropoulou G, Kono M, Anisowicz A, Stenman G, Tsuji S, Sager R (maj 2002). "Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer". Mol Med. 8 (1): 42–55. doi:10.1007/BF03402002. PMC 2039932. PMID 11984005.
- ↑ "Entrez Gene: ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2".
- ↑ "UniProt, Q9UJ37". Pristupljeno 11. 6. 2021.
Dopunska literatura
[uredi | uredi izvor]- Li GS, Zhu L, Zhang H, et al. (2007). "Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy". Hum. Mutat. 28 (10): 950–7. doi:10.1002/humu.20543. PMID 17480010. S2CID 7286057.
- Raska M, Moldoveanu Z, Suzuki H, et al. (2007). "Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells". J. Mol. Biol. 369 (1): 69–78. doi:10.1016/j.jmb.2007.03.002. PMC 1995659. PMID 17418236.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Samyn-Petit B, Krzewinski-Recchi MA, Steelant WF, et al. (2000). "Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells". Biochim. Biophys. Acta. 1474 (2): 201–11. doi:10.1016/s0304-4165(00)00020-9. PMID 10742600.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.