SEBOX

SEBOX
Identifikatori
Aliasi	SEBOX
Vanjski ID-jevi	OMIM: 610975 MGI: 108012 HomoloGene: 32052 GeneCards: SEBOX
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	28,365,199 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	78,395,907 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • molekularna funkcija;
Ćelijska komponenta	• jedro; • ćelijska komponenta;
Biološki proces	• multicellular organism development; • Ćelijska diferencijacija; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0022610 biološki proces; • embryo development ending in birth or egg hatching; • Ovogeneza;
	Izvori:Amigo / QuickGO
Ortolozi
	645832
	18292
	ENSG00000274529
	ENSMUSG00000001103
	Q9HB31
	P70368
	NM_001083896; NM_001080837
	NM_008759
	NP_001074306
	NP_032785
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Alfa-N-acetilgalaktosaminid alfa-2,6-sialiltransferaza 2 je enzim koji je kod ljudi kodiran genom ST6GALNAC2.^[5]^[6]

Dužina polipeptidnog lanca je 374 aminokiseline, a molekulska težina 41.939.^[7].

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MGLPRGSFFW	LLLLLTAACS	GLLFALYFSA	VQRYPGPAAG	ARDTTSFEAF
FQSKASNSWT	GKGQACRHLL	HLAIQRHPHF	RGLFNLSIPV	LLWGDLFTPA
LWDRLSQHKA	PYGWRGLSHQ	VIASTLSLLN	GSESAKLFAP	PRDTPPKCIR
CAVVGNGGIL	NGSRQGPNID	AHDYVFRLNG	AVIKGFERDV	GTKTSFYGFT
VNTMKNSLVS	YWNLGFTSVP	QGQDLQYIFI	PSDIRDYVML	RSAILGVPVP
EGLDKGDRPH	AYFGPEASAS	KFKLLHPDFI	SYLTERFLKS	KLINTHFGDL
YMPSTGALML	LTALHTCDQV	SAYGFITSNY	WKFSDHYFER	KMKPLIFYAN
HDLSLEAALW	RDLHKAGILQ	LYQR

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000274529 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001103 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sotiropoulou G, Kono M, Anisowicz A, Stenman G, Tsuji S, Sager R (maj 2002). "Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer". Mol Med. 8 (1): 42–55. doi:10.1007/BF03402002. PMC 2039932. PMID 11984005.
^ "Entrez Gene: ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2".
^ "UniProt, Q9UJ37". Pristupljeno 11. 6. 2021.

Dopunska literatura[uredi | uredi izvor]

Li GS, Zhu L, Zhang H, et al. (2007). "Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy". Hum. Mutat. 28 (10): 950–7. doi:10.1002/humu.20543. PMID 17480010. S2CID 7286057.
Raska M, Moldoveanu Z, Suzuki H, et al. (2007). "Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells". J. Mol. Biol. 369 (1): 69–78. doi:10.1016/j.jmb.2007.03.002. PMC 1995659. PMID 17418236.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Samyn-Petit B, Krzewinski-Recchi MA, Steelant WF, et al. (2000). "Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells". Biochim. Biophys. Acta. 1474 (2): 201–11. doi:10.1016/s0304-4165(00)00020-9. PMID 10742600.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000274529 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001103 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11984005-5] Sotiropoulou G, Kono M, Anisowicz A, Stenman G, Tsuji S, Sager R (maj 2002). "Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer". Mol Med. 8 (1): 42–55. doi:10.1007/BF03402002. PMC 2039932. PMID 11984005.

[entrez-6] "Entrez Gene: ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2".

[UniProt-7] "UniProt, Q9UJ37". Pristupljeno 11. 6. 2021.

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