SPZ1

SPZ1
Identifikatori
Aliasi	SPZ1
Vanjski ID-jevi	OMIM: 618068 MGI: 1930801 HomoloGene: 49934 GeneCards: SPZ1
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	80,321,842 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	92,712,680 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity;
Ćelijska komponenta	• citoplazma; • jedro;
Biološki proces	• transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	84654
	79401
	ENSG00000164299
	ENSMUSG00000046957
	Q9BXG8
	Q99MY0
	NM_032567
	NM_030237
	NP_115956
	NP_084513
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 1 spermatogenog leucinskog zatvarača jest protein koji je kod ljudi kodiran genom SPZ1 sa hromosoma 5. is a protein that in humans is encoded by the [[gen.^[5]^[6]^[7]^[8]^[9]^[10]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 430 aminokiselina, а molekulska težina 49.445 Da.^[11]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MASSAKSAEM	PTISKTVNPT	PDPHQEYLDP	RITIALFEIG	SHSPSSWGSL
PFLKNSSHQV	TEQQTAQKFN	NLLKEIKDIL	KNMAGFEEKI	TEAKELFEET
NITEDVSAHK	ENIRGLDKIN	EMLSTNLPVS	LAPEKEDNEK	KQEMILETNI
TEDVSAHKEN	IRGLDKINEM	LSTNLPVSLA	PEKEDNEKKQ	QMIMENQNSE
NTAQVFARDL	VNRLEEKKVL	NETQQSQEKA	KNRLNVQEET	MKIRNNMEQL
LQEAEHWSKQ	HTELSKLIKS	YQKSQKDISE	TLGNNGVGFQ	TQPNNEVSAK
HELEEQVKKL	SHDTYSLQLM	AALLENECQI	LQQRVEILKE	LHHQKQGTLQ
EKPIQINYKQ	DKKNQKPSEA	KKVEMYKQNK	QAMKGTFWKK	DRSCRSLDVC
LNKKACNTQF	NIHVARKALR	GKMRSASSLR

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000164299 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046957 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hsu SH, Shyu HW, Hsieh-Li HM, Li H (Feb 2001). "Spz1, a novel bHLH-Zip protein, is specifically expressed in testis". Mech Dev. 100 (2): 177–87. doi:10.1016/S0925-4773(00)00513-X. PMID 11165476. S2CID 17206805.
↑ Sha JH, Zhou ZM, Li JM, Lin M, Zhu H, Zhu H, Zhou YD, Wang LL, Wang YQ, Zhou KY (Jun 2003). "Expression of a novel bHLH-Zip gene in human testis". Asian J Androl. 5 (2): 83–8. PMID 12778315.
↑ Hrabchak C, Varmuza S (Aug 2004). "Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis". J Biol Chem. 279 (35): 37079–86. doi:10.1074/jbc.M403710200. PMID 15226296.
↑ Horowitz E, Zhang Z, Jones BH, Moss SB, Ho C, Wood JR, Wang X, Sammel MD, Strauss JF 3rd (Apr 2005). "Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins". Mol Hum Reprod. 11 (4): 307–17. doi:10.1093/molehr/gah163. PMID 15829580.
↑ Hsu SH, Hsieh-Li HM, Huang HY, Huang PH, Li H (maj 2005). "bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis". Cancer Res. 65 (10): 4041–50. doi:10.1158/0008-5472.CAN-04-3658. PMID 15899793.
↑ "Entrez Gene: SPZ1 spermatogenic leucine zipper 1".
↑ "UniProt, Q9BXG8" (jezik: engleski). Pristupljeno 20. 10. 2021.

Dopunska literatura

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5" (PDF). Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi:10.1038/nature02919. PMID 15372022. S2CID 4373053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164299 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046957 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11165476-5] Hsu SH, Shyu HW, Hsieh-Li HM, Li H (Feb 2001). "Spz1, a novel bHLH-Zip protein, is specifically expressed in testis". Mech Dev. 100 (2): 177–87. doi:10.1016/S0925-4773(00)00513-X. PMID 11165476. S2CID 17206805.

[pmid12778315-6] Sha JH, Zhou ZM, Li JM, Lin M, Zhu H, Zhu H, Zhou YD, Wang LL, Wang YQ, Zhou KY (Jun 2003). "Expression of a novel bHLH-Zip gene in human testis". Asian J Androl. 5 (2): 83–8. PMID 12778315.

[pmid15226296-7] Hrabchak C, Varmuza S (Aug 2004). "Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis". J Biol Chem. 279 (35): 37079–86. doi:10.1074/jbc.M403710200. PMID 15226296.

[pmid15829580-8] Horowitz E, Zhang Z, Jones BH, Moss SB, Ho C, Wood JR, Wang X, Sammel MD, Strauss JF 3rd (Apr 2005). "Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins". Mol Hum Reprod. 11 (4): 307–17. doi:10.1093/molehr/gah163. PMID 15829580.

[pmid15899793-9] Hsu SH, Hsieh-Li HM, Huang HY, Huang PH, Li H (maj 2005). "bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis". Cancer Res. 65 (10): 4041–50. doi:10.1158/0008-5472.CAN-04-3658. PMID 15899793.

[entrez-10] "Entrez Gene: SPZ1 spermatogenic leucine zipper 1".

[UniProt-11] "UniProt, Q9BXG8" (jezik: engleski). Pristupljeno 20. 10. 2021.

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