SSCEL
Scijelin je protein koji je kod ljudi kodiran genom SCEL.[5][6]
Protein kodiran ovim genom je prekursor orožnjalog omotača terminalno diferenciranih keratinocita. Ovaj protein se lokalizira na periferiji ćelija i može funkcionirati u sastavljanju ili regulaciji proteina u rožnoj ovojnici. Postoje varijante transkripta koje kodiraju različite izoforme. Varijanta transkripta koja koristi alternativu polyA signal opisana je u literaturi, ali njena dužina nije utvrđena.[6]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 688 aminokiselina, a molekulska težina 77 552 Da.[7].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSNVTLRKMS | PTGNEMKSTT | QGTTRKQQDF | HEVNKRRTFL | QDNSWIKKRP | ||||
| EEEKDENYGR | VVLNRHNSHD | ALDRKVNERD | VPKATISRYS | SDDTLDRISD | ||||
| RNDAAKTYKA | NTLDNQLTNR | SMSMFRSLEV | TKLQPGGSLN | ANTSNTIAST | ||||
| SATTPVKKKR | QSWFPPPPPG | YNASSSTGTR | RREPGVHPPI | PPKPSSPVSS | ||||
| PNQLRQDNRQ | IHPPKPGVYT | ETNRSAERNI | RSQDLDNIVK | VATSLQRSDK | ||||
| GEELDNLIKM | NKSLNRNQGL | DSLFRANPKV | EEREKRAKSL | ESLIYMSTRT | ||||
| DKDGKGIQSL | GSPIKVNQRT | DKNEKGRQNL | ESVAKVNARM | NKTSRRSEDL | ||||
| DNATEVNPKG | HENTTGKKDL | DGLIKVDPET | NKNITRGQSL | DNLIKVTPEV | ||||
| KRSNQGSKDL | NNFIKVYPGT | EKSTEGGQSL | DSLIKVTPER | NRTNQGNQDL | ||||
| ENLIKVIPSA | NKSSEQGLDE | HINVSPKAVK | NTDGKQDLDK | LIKVNPEIFT | ||||
| NNQRNQDLAN | LIKVNPAVIR | NNQSQDLDNL | IKVKPSALRN | TNRDQNLENL | ||||
| IEVNSHVSEN | KNGSSNTGAK | QAGPQDTVVY | TRTYVENSKS | PKDGYQENIS | ||||
| GKYIQTVYST | SDRSVIERDM | CTYCRKPLGV | ETKMILDELQ | ICCHSTCFKC | ||||
| EICKQPLENL | QAGDSIWIYR | QTIHCEPCYS | KIMAKWIP |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000136155 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022123 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Champliaud MF, Burgeson RE, Jin W, Baden HP, Olson PF (Dec 1998). "cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope". J Biol Chem. 273 (47): 31547–54. doi:10.1074/jbc.273.47.31547. PMID 9813070.
- ^ a b "Entrez Gene: SCEL sciellin".
- ^ "UniProt, O95171". Pristupljeno 5. 8. 2021.
Dopunska literatura[uredi | uredi izvor]
- Corona W, Karkera DJ, Patterson RH, et al. (2004). "Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma". Anticancer Res. 24 (3a): 1417–9. PMID 15274303.
- Champliaud MF, Viel A, Baden HP (2003). "The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes". J. Invest. Dermatol. 121 (4): 781–5. doi:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Champliaud MF, Baden HP, Koch M, et al. (2001). "Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties". Genomics. 70 (2): 264–8. doi:10.1006/geno.2000.6390. PMID 11112355.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Kvedar JC, Manabe M, Phillips SB, et al. (1992). "Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes". Differentiation. 49 (3): 195–204. doi:10.1111/j.1432-0436.1992.tb00667.x. PMID 1377656.