TCP11

TCP11
Identifikatori
Aliasi	TCP11
Vanjski ID-jevi	OMIM: 186982 MGI: 98544 HomoloGene: 8433 GeneCards: TCP11
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	35,148,610 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	28,080,639 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • membrana; • Akrozom; • GO:0016023 citoplazmatska vezikula; • sperm flagellum; • projekcija ćelije; • sperm midpiece; • motile cilium; • Treplja;
Biološki proces	• Ćelijska diferencijacija; • Spermatogeneza; • multicellular organism development; • protein kinase A signaling; • regulation of cAMP-mediated signaling; • regulation of sperm capacitation;
	Izvori:Amigo / QuickGO
Ortolozi
	6954
	21463
	ENSG00000124678
	ENSMUSG00000062859
	Q8WWU5
	Q01755
NM_001093728; NM_001261817; NM_001261818; NM_001261819; NM_001261820;
	NM_001261821; NM_018679
	NM_001085555; NM_013687; NM_001357681; NM_001374620; NM_001374621
NP_001248746; NP_001248747; NP_001248748; NP_001248749; NP_001248750;
	NP_061149; NP_001353252; NP_001353253; NP_001353254; NP_001353255; NP_001353256; NP_001353257; NP_001353258; NP_001353259; NP_001353260; NP_001353261; NP_001357616
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Homolog T-kompleksnog proteina 11 jest protein koji je kod ljudi kodiran genom TCP11.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 503 aminokiseline, а molekulska težina 56.141 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPDVKESVPP	KYPGDSEGRS	CKPETSGPPQ	EDKSGSEDPP	PFLSVTGLTE
TVNEVSKLSN	KIGMNCDYYM	EEKVLPPSSL	EGKVKETVHN	AFWDHLKEQL
SATPPDFSCA	LELLKEIKEI	LLSLLLPRQN	RLRIEIEEAL	DMDLLKQEAE
HGALKVLYLS	KYVLNMMALL	CAPVRDEAVQ	KLENITDPVW	LLRGIFQVLG
RMKMDMVNYT	IQSLQPHLQE	HSIQYERAKF	QELLNKQPSL	LNHTTKWLTQ
AAGDLTMSPP	TCPDTSDSSS	VAGPSPNEAA	NNPEPLSPTM	VLCQGFLNLL
LWDLENEEFP	ETLLMDRTRL	QELKSQLHQL	TVMASVLLVA	SSFSGSVLFG
SPQFVDKLKR	ITKSLLEDFH	SRPEEAILTV	SEQVSQEIHQ	SLKNMGLVAL
SSDNTASLMG	QLQNIAKKEN	CVCSVIDQRI	HLFLKCCLVL	GVQRSLLDLP
GGLTLIEAEL	AELGQKFVNL	THHNQQVFGP	YYTEILKTLI	SPAQALETKV
ESV

Modelni organizmi[uredi | uredi izvor]

U proučavanju funkcije TCP11 korišteni su i modelni organizmi. Uslovna linija nokaut-miševa pod zvana Tcp11^{tm1a(EUCOMM)Wtsi} generirana je u Institutu Wellcome Trust Sanger.^[9] Mužjaci i ženke podvrgnuti su standardiziranom fenotipskom pregledu 26 odabranih svojstava^[10] za otkrivanje efekata delecija.^[11]^[12]^[13]^[14] Dodatni pregledi obavljeni su dubokim imunološkim fenotipiziranjem, pri čemu nije uočena bilo koja nenormalnost.^[15]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124678 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062859 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ragoussis J, Senger G, Mockridge I, Sanseau P, Ruddy S, Dudley K, Sheer D, Trowsdale J (Nov 1992). "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11". Genomics. 14 (3): 673–9. doi:10.1016/S0888-7543(05)80167-3. PMID 1427894.
^ Ma Y, Zhang S, Xia Q, Zhang G, Huang X, Huang M, Xiao C, Pan A, Sun Y, Lebo R, Milunsky A (Jan 2002). "Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide". Molecular Human Reproduction. 8 (1): 24–31. doi:10.1093/molehr/8.1.24. PMID 11756566.
^ "Entrez Gene: TCP11 t-complex 11 (mouse)".
^ "UniProt, Q8WWU5" (jezik: engleski). Pristupljeno 5. 10. 2021.
^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
^ "International Mouse Phenotyping Consortium".
^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
^ "Infection and Immunity Immunophenotyping (3i) Consortium".^{[mrtav link]}

Dopunska literatura[uredi | uredi izvor]

Ma YX, Zhang SZ, Wu QQ, Sun Y, Qiu WM, Xu WM (Apr 2003). "[Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 25 (2): 122–8. PMID 12905703.
Ma YX, Zhang SZ, Wu QQ, Sun Y (Feb 2003). "[Cloning, expression and alternative splicing of a novel isoform of human TCP11b gene]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 35 (2): 182–8. PMID 12545228.
Fraser LR, Hosseini R, Hanyalogou A, Talmor A, Dudley RK (Nov 1997). "TCP-11, the product of a mouse t-complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reaction". Molecular Reproduction and Development. 48 (3): 375–82. doi:10.1002/(SICI)1098-2795(199711)48:3<375::AID-MRD11>3.0.CO;2-V. PMID 9322250.
Mazarakis ND, Nelki D, Lyon MF, Ruddy S, Evans EP, Freemont P, Dudley K (Feb 1991). "Isolation and characterisation of a testis-expressed developmentally regulated gene from the distal inversion of the mouse t-complex". Development. 111 (2): 561–71. PMID 1893875.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124678 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062859 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427894-5] Ragoussis J, Senger G, Mockridge I, Sanseau P, Ruddy S, Dudley K, Sheer D, Trowsdale J (Nov 1992). "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11". Genomics. 14 (3): 673–9. doi:10.1016/S0888-7543(05)80167-3. PMID 1427894.

[pmid11756566-6] Ma Y, Zhang S, Xia Q, Zhang G, Huang X, Huang M, Xiao C, Pan A, Sun Y, Lebo R, Milunsky A (Jan 2002). "Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide". Molecular Human Reproduction. 8 (1): 24–31. doi:10.1093/molehr/8.1.24. PMID 11756566.

[entrez-7] "Entrez Gene: TCP11 t-complex 11 (mouse)".

[UniProt-8] "UniProt, Q8WWU5" (jezik: engleski). Pristupljeno 5. 10. 2021.

[mgp_reference-9] Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.

[IMPCsearch_ref-10] "International Mouse Phenotyping Consortium".

[pmid21677750-11] Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

[mouse_library-12] Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.

[mouse_for_all_reasons-13] Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.

[pmid23870131-14] White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.

[iii_ref-15] "Infection and Immunity Immunophenotyping (3i) Consortium".^{[mrtav link]}

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