S Wikipedije, slobodne enciklopedije
Timocitni jedarni protein 1 je protein koji je kod ljudi kodiran genom THYN1 .[5] [6] [7]
Ovaj gen kodira protein koji je visoko konzerviran među kičmenjacima i biljnim vrstama i može biti uključen u indukciju apoptoze . Opisane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme .[7]
Dužina polipeptidnog lanca je 225 aminokiselina , а molekulska težina 25.697 Da .[8]
10 20 30 40 50 MSRPRKRLAG TSGSDKGLSG KRTKTENSGE ALAKVEDSNP QKTSATKNCL KNLSSHWLMK SEPESRLEKG VDVKFSIEDL KAQPKQTTCW DGVRNYQARN FLRAMKLGEE AFFYHSNCKE PGIAGLMKIV KEAYPDHTQF EKNNPHYDPS SKEDNPKWSM VDVQFVRMMK RFIPLAELKS YHQAHKATGG PLKNMVLFTR QRLSIQPLTQ EEFDFVLSLE EKEPS
^ a b c GRCh38: Ensembl release 89: ENSG00000151500 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035443 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Jiang XZ, Toyota H, Yoshimoto T, Takada E, Asakura H, Mizuguchi J (Nov 2003). "Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells". Apoptosis . 8 (5): 509–19. doi :10.1023/A:1025594409056 . PMID 14601557 . S2CID 2092518 . ^ Miyaji H, Yoshimoto T, Asakura H, Komachi A, Kamiya S, Takasaki M, Mizuguchi J (Oct 2002). "Molecular cloning and characterization of the mouse thymocyte protein gene". Gene . 297 (1–2): 189–96. doi :10.1016/S0378-1119(02)00886-7 . PMID 12384300 . ^ a b "Entrez Gene: THYN1 thymocyte nuclear protein 1" .^ "UniProt, Q9P016" . Pristupljeno 28. 8. 2021 .
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . Genome Res . 10 (10): 1546–60. doi :10.1101/gr.140200 . PMC 310934 PMID 11042152 . Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis . 8 : 196–204. PMID 12107411 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Jiang X, Toyota H, Takada E, et al. (2004). "Modulation of mThy28 nuclear protein expression during thymocyte development". Tissue & Cell . 35 (6): 471–8. doi :10.1016/S0040-8166(03)00073-9 . PMID 14580360 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Song AX, Chang YG, Gao YG, et al. (2005). "Identification, expression, and purification of a unique stable domain from human HSPC144 protein". Protein Expr. Purif . 42 (1): 146–52. doi :10.1016/j.pep.2005.03.008 . PMID 15939300 . 
