S Wikipedije, slobodne enciklopedije
Porimin ili transmembranski protein 123 je protein koji je kod ljudi kodiran genom TMEM123 .[5] [6]
Ovaj gen kodira visoko glikozilirani transmembranski protein s visokim sadržajem ostataka treonina i serina u svom vanćelijskom domenu, slično široko definiranoj kategoriji proteina zvanoj mucini .
Izloženost nekih tipova ćelija antiporminskih (ozljeda membrane koja izaziva receptore proonkoze) antitijela , umrežava ovaj protein na ćelijskoj površini i izaziva tip ćelijske smrti koji se naziva onkoza .
Onkoza se razlikuje od apoptoze i karakterizira je gubitak integriteta ćelijske membrane bez fragmentacije DNK . Predloženo je da ovaj genski proizvod funkcionira kao receptor na ćelijskoj površini koji posreduje u ćelijskoj smrti .[6]
Dužina polipeptidnog lanca je 208 aminokiselina , а molekulska težina 21.531 Da .[7]
10 20 30 40 50 MGLGARGAWA ALLLGTLQVL ALLGAAHESA AMAASANIEN SGLPHNSSAN STETLQHVPS DHTNETSNST VKPPTSVASD SSNTTVTTMK PTAASNTTTP GMVSTNMTST TLKSTPKTTS VSQNTSQIST STMTVTHNSS VTSAASSVTI TTTMHSEAKK GSKFDTGSFV GGIVLTLGVL SILYIGCKMY YSRRGIRYRT IDEHDAII
^ a b c GRCh38: Ensembl release 89: ENSG00000152558 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050912 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ma F, Zhang C, Prasad KV, Freeman GJ, Schlossman SF (Aug 2001). "Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death" . Proc Natl Acad Sci U S A . 98 (17): 9778–83. doi :10.1073/pnas.171322898 . PMC 55529 PMID 11481458 . ^ a b "Entrez Gene: TMEM123 transmembrane protein 123" .^ "UniProt, Q8N131" . Pristupljeno 28. 8. 2021 .
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