UNC5C

UNC5C
Identifikatori
Aliasi	UNC5C
Vanjski ID-jevi	OMIM: 603610 MGI: 1095412 HomoloGene: 2765 GeneCards: UNC5C
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	95,549,206 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	141,540,685 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• netrin receptor activity; • netrin receptor activity involved in chemorepulsion; • GO:0001948, GO:0016582 vezivanje za proteine; • protein kinase binding; • vezivanje tubulina;
Ćelijska komponenta	• integral component of membrane; • neuron projection; • međućelijske veze; • ćelijska membrana; • sinapsa; • membrana; • Akson; • dendrit; • growth cone; • neuronal cell body; • lamellipodium; • Filopodija; • cell surface; • projekcija ćelije;
Biološki proces	• positive regulation of apoptotic process; • netrin-activated signaling pathway; • multicellular organism development; • brain development; • regulation of cell migration; • GO:0072468 Transdukcija signala; • anterior/posterior axon guidance; • axon guidance; • GO:0097285 apoptoza; • negative chemotaxis; • chemorepulsion of axon; • dorsal root ganglion development;
	Izvori:Amigo / QuickGO
Ortolozi
	8633
	22253
	ENSG00000182168
	ENSMUSG00000059921
	O95185
	O08747
	NM_003728
	NM_001293561; NM_009472
	NP_003719
	NP_001280490; NP_033498
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Netrinski receptor UNC5C jest protein koji je kod ljudi kodiran genom UNC5C sa hromosoma 4.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 931 aminokiselina, а molekulska težina 103.146 Da.^[8].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRKGLRATAA	RCGLGLGYLL	QMLVLPALAL	LSASGTGSAA	QDDDFFHELP
ETFPSDPPEP	LPHFLIEPEE	AYIVKNKPVN	LYCKASPATQ	IYFKCNSEWV
HQKDHIVDER	VDETSGLIVR	EVSIEISRQQ	VEELFGPEDY	WCQCVAWSSA
GTTKSRKAYV	RIAYLRKTFE	QEPLGKEVSL	EQEVLLQCRP	PEGIPVAEVE
WLKNEDIIDP	VEDRNFYITI	DHNLIIKQAR	LSDTANYTCV	AKNIVAKRKS
TTATVIVYVN	GGWSTWTEWS	VCNSRCGRGY	QKRTRTCTNP	APLNGGAFCE
GQSVQKIACT	TLCPVDGRWT	PWSKWSTCGT	ECTHWRRREC	TAPAPKNGGK
DCDGLVLQSK	NCTDGLCMQT	APDSDDVALY	VGIVIAVIVC	LAISVVVALF
VYRKNHRDFE	SDIIDSSALN	GGFQPVNIKA	ARQDLLAVPP	DLTSAAAMYR
GPVYALHDVS	DKIPMTNSPI	LDPLPNLKIK	VYNTSGAVTP	QDDLSEFTSK
LSPQMTQSLL	ENEALSLKNQ	SLARQTDPSC	TAFGSFNSLG	GHLIVPNSGV
SLLIPAGAIP	QGRVYEMYVT	VHRKETMRPP	MDDSQTLLTP	VVSCGPPGAL
LTRPVVLTMH	HCADPNTEDW	KILLKNQAAQ	GQWEDVVVVG	EENFTTPCYI
QLDAEACHIL	TENLSTYALV	GHSTTKAAAK	RLKLAIFGPL	CCSSLEYSIR
VYCLDDTQDA	LKEILHLERQ	MGGQLLEEPK	ALHFKGSTHN	LRLSIHDIAH
SLWKSKLLAK	YQEIPFYHVW	SGSQRNLHCT	FTLERFSLNT	VELVCKLCVR
QVEGEGQIFQ	LNCTVSEEPT	GIDLPLLDPA	NTITTVTGPS	AFSIPLPIRQ
KLCSSLDAPQ	TRGHDWRMLA	HKLNLDRYLN	YFATKSSPTG	VILDLWEAQN
FPDGNLSMLA	AVLEEMGRHE	TVVSLAAEGQ	Y

Funkcija[uredi | uredi izvor]

Ovaj genski proizvod pripada UNC-5 porodici netrinskih receptora. Netrini su izlučeni proteini koji usmjeravaju proširenje aksona i migraciju ćelija tokom neuralnog razvoja. Oni su bifunkcionalni proteini koji djeluju kao atraktanti za neke tipove ćelioja i kao repelenti za druge, a smatra se da ova suprotna djelovanja posreduju dvije klase receptora. Porodica receptora UNC-5 posreduju u repelentnom odgovoru na netrin; oni su transmembranski proteini koji sadrže dva imunoglobulinska (Ig) domena i dva tipa I trombospondinskih motiva u vanćelijskoj regiji.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182168 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059921 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (maj 1997). "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors". Nature. 386 (6627): 833–8. Bibcode:1997Natur.386..833L. doi:10.1038/386833a0. PMID 9126742. S2CID 1232956.
^ Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23". Genomics. 52 (2): 205–8. doi:10.1006/geno.1998.5425. PMID 9782087.
^ ^a ^b "Entrez Gene: UNC5C unc-5 homolog C (C. elegans)".
^ "UniProt, O95185" (jezik: engleski). Pristupljeno 28. 10. 2017.

Dopunska literatuta[uredi | uredi izvor]

Kennedy TE (2001). "Cellular mechanisms of netrin function: long-range and short-range actions". Biochem. Cell Biol. 78 (5): 569–75. doi:10.1139/bcb-78-5-569. PMID 11103947.
Livesey FJ (2001). "Netrins and netrin receptors". Cell. Mol. Life Sci. 56 (1–2): 62–8. doi:10.1007/s000180050006. PMID 11213262. S2CID 33776808.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Thiebault K, Mazelin L, Pays L, et al. (2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4173–8. Bibcode:2003PNAS..100.4173T. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
Geisbrecht BV, Dowd KA, Barfield RW, et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kruger RP, Lee J, Li W, Guan KL (2005). "Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation". J. Neurosci. 24 (48): 10826–34. doi:10.1523/JNEUROSCI.3715-04.2004. PMC 6730211. PMID 15574733.
Llambi F, Lourenço FC, Gozuacik D, et al. (2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". EMBO J. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.
Bernet A, Mazelin L, Coissieux MM, et al. (2008). "Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies". Gastroenterology. 133 (6): 1840–8. doi:10.1053/j.gastro.2007.08.009. PMC 2211510. PMID 17967459.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182168 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059921 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9126742-5] Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (maj 1997). "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors". Nature. 386 (6627): 833–8. Bibcode:1997Natur.386..833L. doi:10.1038/386833a0. PMID 9126742. S2CID 1232956.

[pmid9782087-6] Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23". Genomics. 52 (2): 205–8. doi:10.1006/geno.1998.5425. PMID 9782087.

[entrez-7] "Entrez Gene: UNC5C unc-5 homolog C (C. elegans)".

[UniProt-8] "UniProt, O95185" (jezik: engleski). Pristupljeno 28. 10. 2017.

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