CCL16

Pretraga za
Strukture	Swiss-model
Domene	InterPro

Hemokinski (C-C motivni) ligand 16
Hemokinski (C-C motivni) ligand 16
Identifikatori
Simbol	CCL16
Alt. simboli	SCYA16, NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1
NCBI gen	6360
HGNC	10614
OMIM	601394
RefSeq	NM_004590
UniProt	O15467
Ostali podaci
Lokus	Hrom. 17 q11.2
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

CCL16
Identifikatori
Aliasi	CCL16
Vanjski ID-jevi	OMIM: 601394 HomoloGene: 48291 GeneCards: CCL16
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	35,981,497 bp
Ontologija gena
Molekularna funkcija	• cytokine activity; • CCR chemokine receptor binding; • chemoattractant activity; • chemokine activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• monocyte chemotaxis; • chemokine-mediated signaling pathway; • cell-cell signaling; • cellular response to tumor necrosis factor; • neutrophil chemotaxis; • Hemotaksija; • cell communication; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • cellular response to interleukin-1; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • positive regulation of ERK1 and ERK2 cascade; • cellular response to interferon-gamma; • lymphocyte chemotaxis; • inflammatory response; • positive chemotaxis; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • eosinophil chemotaxis;
	Izvori:Amigo / QuickGO
Ortolozi
	6360
	n/a
	ENSG00000275152; ENSG00000275095
	n/a
	O15467
	n/a
	NM_004590
	n/a
	NP_004581
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Hemokinski (C-C motivni) ligand 16 (CCL16) jest mali citokin koji pripada porodici CC hemokina i poznat je pod nekoliko pseudonima, uključujući hemokine koji eksprimira jetra (LEC) i monotaktin-1 (MTN-1). Ovaj hemokin se ekspimira u jetri, timusu i slezeni i hemoatraktivan je za monocite i limfocite.^[3] Ćelijska ekspresija CCL16 može se snažno inducirati u monocitima pomoću InterleukinIL-10, IFN-γ i bakterijsi lipopolisaharid. Njegov gen nalazi se na hromosomu 17, kod ljudi, među skupinom ostalih CC-hemokina.^[4] CCL16 izaziva učinke na ćelije interakcijom sa hemokinskim receptorima na površini ćelije, kao što su CCR1, CCR2, CCR5 i CCR8.^[5]^[6]

C-C motiv hemokinskih liganada 16 pronađen je u visokim nivoima u ljudskoj krvnoj plazmi.^[7] CCL16 može biti koristan za promet eozinofila. Utvrđeno je da ovaj ligand ima funkcionalni afinitet za H4 receptore koji se eksprimiraju u eozinofilima i mastocitima.^[7] Pokazano je da ovaj hemokin suzbija brzu proliferaciju mijeloidnih progenitornih ćelija.^[8]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 120 aminokiselina, a molekulska težina 13.600 Da.^[9].

10	20	30	40	50
MKVSEAALSL	LVLILIITSA	SRSQPKVPEW	VNTPSTCCLK	YYEKVLPRRL
VVGYRKALNC	HLPAIIFVTK	RNREVCTNPN	DDWVQEYIKD	PNLPLLPTRN
LSTVKIITAK	NGQPQLLNSQ

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference[uredi | uredi izvor]

^ ^a ^b ^c ENSG00000275095 GRCh38: Ensembl release 89: ENSG00000275152, ENSG00000275095 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Youn BS, Zhang S, Broxmeyer HE, Antol K, Fraser MJ, Hangoc G, Kwon BS (juni 1998). "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity". Biochemical and Biophysical Research Communications. 247 (2): 217–22. doi:10.1006/bbrc.1998.8762. PMID 9642106.
^ Nomiyama H, Fukuda S, Iio M, Tanase S, Miura R, Yoshie O (mart 1999). "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES". Journal of Interferon & Cytokine Research. 19 (3): 227–34. doi:10.1089/107999099314153. PMID 10213461.
^ Nomiyama H, Hieshima K, Nakayama T, Sakaguchi T, Fujisawa R, Tanase S, Nishiura H, Matsuno K, Takamori H, Tabira Y, Yamamoto T, Miura R, Yoshie O (august 2001). "Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes". International Immunology. 13 (8): 1021–9. doi:10.1093/intimm/13.8.1021. PMID 11470772.
^ Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ (august 2000). "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8". Blood. 96 (3): 840–5. doi:10.1182/blood.V96.3.840. PMID 10910894.
^ ^a ^b Nakayama T, Kato Y, Hieshima K, Nagakubo D, Kunori Y, Fujisawa T, Yoshie O (august 2004). "Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor". Journal of Immunology. 173 (3): 2078–83. doi:10.4049/jimmunol.173.3.2078. PMID 15265943.
^ "CCL16 C-C Motif Chemokine Ligand 16 [Homo Sapiens (Human)] Gene". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "UniProt, O15467". Pristupljeno 28. 6. 2021.

[refGRCh38Ensembl-1] ENSG00000275095 GRCh38: Ensembl release 89: ENSG00000275152, ENSG00000275095 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Youn_1998-3] Youn BS, Zhang S, Broxmeyer HE, Antol K, Fraser MJ, Hangoc G, Kwon BS (juni 1998). "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity". Biochemical and Biophysical Research Communications. 247 (2): 217–22. doi:10.1006/bbrc.1998.8762. PMID 9642106.

[Nomiyama_1991-4] Nomiyama H, Fukuda S, Iio M, Tanase S, Miura R, Yoshie O (mart 1999). "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES". Journal of Interferon & Cytokine Research. 19 (3): 227–34. doi:10.1089/107999099314153. PMID 10213461.

[Nomiyama_2001-5] Nomiyama H, Hieshima K, Nakayama T, Sakaguchi T, Fujisawa R, Tanase S, Nishiura H, Matsuno K, Takamori H, Tabira Y, Yamamoto T, Miura R, Yoshie O (august 2001). "Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes". International Immunology. 13 (8): 1021–9. doi:10.1093/intimm/13.8.1021. PMID 11470772.

[Howard_2000-6] Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ (august 2000). "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8". Blood. 96 (3): 840–5. doi:10.1182/blood.V96.3.840. PMID 10910894.

[Nakayama_2004-7] Nakayama T, Kato Y, Hieshima K, Nagakubo D, Kunori Y, Fujisawa T, Yoshie O (august 2004). "Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor". Journal of Immunology. 173 (3): 2078–83. doi:10.4049/jimmunol.173.3.2078. PMID 15265943.

[entrez-8] "CCL16 C-C Motif Chemokine Ligand 16 [Homo Sapiens (Human)] Gene". National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniProt-9] "UniProt, O15467". Pristupljeno 28. 6. 2021.

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