CDC42EP1

CDC42EP1
Identifikatori
Aliasi	CDC42EP1
Vanjski ID-jevi	OMIM: 606084 MGI: 1929763 HomoloGene: 5128 GeneCards: CDC42EP1
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	37,569,405 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	78,735,097 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • cadherin binding involved in cell-cell adhesion;
Ćelijska komponenta	• citoskelet; • membrana; • Endomembranski sistem; • focal adhesion; • citoplazma; • ćelijska membrana;
Biološki proces	• positive regulation of pseudopodium assembly; • positive regulation of actin filament polymerization; • Rho protein signal transduction; • regulation of cell shape; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • cell-cell adhesion;
	Izvori:Amigo / QuickGO
Ortolozi
	11135
	104445
	ENSG00000128283
	ENSMUSG00000049521
	Q00587
	Q91W92
	NM_152243
	NM_027219
	NP_689449
	NP_081495
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Proteinski efektor 1Cdc42 jest protein koji je kod ljudi kodiran genom CDC42EP1 sa hromosoma 22.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 391 aminokiselina, a molekulska težina 40 295 Da.

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPGPQGGRGA	ATMSLGKLSP	VGWVSSSQGK	RRLTADMISH	PLGDFRHTMH
VGRGGDVFGD	TSFLSNHGGS	SGSTHRSPRS	FLAKKLQLVR	RVGAPPRRMA
SPPAPSPAPP	AISPIIKNAI	SLPQLNQAAY	DSLVVGKLSF	DSSPTSSTDG
HSSYGLDSGF	CTISRLPRSE	KPHDRDRDGS	FPSEPGLRRS	DSLLSFRLDL
DLGPSLLSEL	LGVMSLPEAP	AAETPAPAAN	PPAPTANPTG	PAANPPATTA
NPPAPAANPS	APAATPTGPA	ANPPAPAASS	TPHGHCPNGV	TAGLGPVAEV
KSSPVGGGPR	GPAGPALGRH	WGAGWDGGHH	YPEMDARQER	VEVLPQARAS
WESLDEEWRA	PQAGSRTPVP	STVQANTFEF	ADAEEDDEVK	V

Funkcija[uredi | uredi izvor]

CDC42 je član porodice Rho GTPaza koji reguliše višestruke ćelijske aktivnosti, uključujući polimerizaciju aktina. Protein kodiran ovim genom je CDC42 vezujući protein koji posreduje reorganizaciju aktinskog citoskeleta na plazmamembranama. Kodirani protein, koji se luči, prvenstveno se nalazi u koštanoj srži. Za ovaj gen su pronađene dvije varijante transkripta koje kodiraju različite izoforme.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128283 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049521 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bahou WF, Campbell AD, Wicha MS (Aug 1992). "cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression". J Biol Chem. 267 (20): 13986–92. doi:10.1016/S0021-9258(19)49667-1. PMID 1629197.
^ Burbelo PD, Snow DM, Bahou W, Spiegel S (Sep 1999). "MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts". Proc Natl Acad Sci U S A. 96 (16): 9083–8. doi:10.1073/pnas.96.16.9083. PMC 17736. PMID 10430899.
^ ^a ^b "Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1".

Dopunska literatura[uredi | uredi izvor]

Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a New Family of Cdc42 and TC10 GTPase-Interacting Proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC 84628. PMID 10490598.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Hirsch DS, Pirone DM, Burbelo PD (2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J. Biol. Chem. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang J, Zhu J, Bu X, et al. (2005). "Cdc42 and RhoB Activation Are Required for Mannose Receptor-mediated Phagocytosis by Human Alveolar Macrophages". Mol. Biol. Cell. 16 (2): 824–34. doi:10.1091/mbc.E04-06-0463. PMC 545914. PMID 15574879.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CDC42EP1 i stranica sa detaljima o genu CDC42EP1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128283 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049521 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1629197-5] Bahou WF, Campbell AD, Wicha MS (Aug 1992). "cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression". J Biol Chem. 267 (20): 13986–92. doi:10.1016/S0021-9258(19)49667-1. PMID 1629197.

[pmid10430899-6] Burbelo PD, Snow DM, Bahou W, Spiegel S (Sep 1999). "MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts". Proc Natl Acad Sci U S A. 96 (16): 9083–8. doi:10.1073/pnas.96.16.9083. PMC 17736. PMID 10430899.

[entrez-7] "Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1".

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